P30677 · GNA14_MOUSE

  • Protein
    Guanine nucleotide-binding protein subunit alpha-14
  • Gene
    Gna14
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Features

Showing features for binding site.

135550100150200250300350
TypeIDPosition(s)Description
Binding site42-49GTP (UniProtKB | ChEBI)
Binding site49Mg2+ (UniProtKB | ChEBI)
Binding site176-182GTP (UniProtKB | ChEBI)
Binding site182Mg2+ (UniProtKB | ChEBI)
Binding site201-205GTP (UniProtKB | ChEBI)
Binding site270-273GTP (UniProtKB | ChEBI)
Binding site327GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentheterotrimeric G-protein complex
Molecular FunctionG protein-coupled receptor binding
Molecular FunctionG-protein beta/gamma-subunit complex binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionmetal ion binding
Biological Processaction potential
Biological Processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processphospholipase C-activating dopamine receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Guanine nucleotide-binding protein subunit alpha-14
  • Short names
    G alpha-14; G-protein subunit alpha-14

Gene names

    • Name
      Gna14
    • Synonyms
      Gna-14

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N-3
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P30677
  • Secondary accessions
    • Q8R2X9

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002037531-355Guanine nucleotide-binding protein subunit alpha-14

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain34-355G-alpha
Region37-50G1 motif
Region174-182G2 motif
Region197-206G3 motif
Region266-273G4 motif
Region325-330G5 motif

Sequence similarities

Belongs to the G-alpha family. G(q) subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    355
  • Mass (Da)
    41,528
  • Last updated
    2011-07-27 v2
  • Checksum
    D34B39ACD179AE82
MAGCCCLSAEEKESQRISAEIERQLRRDKKDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDRKGFTKLVYQNIFTAMQAMIRAMDTLRIQYMCEQNKENAQIIREVEVDKVTALSRDQVAAIKQLWLDPGIQECYDRRREYQLSDSAKYYLTDIERIAMPSFVPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFESVTSIIFLVALSEYDQVLAECDNENRMEESKALFRTIITYPWFLNSSVILFLNKKDLLEEKIMYSHLISYFPEYTGPKQDVKAARDFILKLYQDQNPDKEKVIYSHFTCATDTENIRFVFAAVKDTILQLNLREFNLV

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A494BBL5A0A494BBL5_MOUSEGna14301

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict24-25in Ref. 1; AAA83222

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M80631
EMBL· GenBank· DDBJ
AAA83222.1
EMBL· GenBank· DDBJ
mRNA
AK160808
EMBL· GenBank· DDBJ
BAE36026.1
EMBL· GenBank· DDBJ
mRNA
AK168498
EMBL· GenBank· DDBJ
BAE40384.1
EMBL· GenBank· DDBJ
mRNA
CH466534
EMBL· GenBank· DDBJ
EDL41541.1
EMBL· GenBank· DDBJ
Genomic DNA
BC027015
EMBL· GenBank· DDBJ
AAH27015.1
EMBL· GenBank· DDBJ
mRNA
M57616
EMBL· GenBank· DDBJ
AAA63304.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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