This study demonstrates that the downstream consequences of Mild traumatic brain injury on lung NK1R levels and connective protein expression enhance neutrophil recruitment to a stimulus that may contribute to increased survival.
elevated plasma SP level up-regulated expression of SP and NK1R indicate that the SP/NK1R complex is important in the development of Atopic dermatitis.
Quantification of mRNA revealed that increased expression of Tacr1 and Avp generally associated with decreased social interaction and increased alcohol intake.
the NK1R-CreER mouse line is a valuable new tool for conditional gene manipulation enabling the visualization and manipulation of cells that express NK1R.
NK1-R expression in the trachea bronchus and lung tissue increased in MP-infected BALB/c mice which may explain why wheezing occurs after MP infection.
These findings suggest that tachykinins and NK1 receptors play a key role in joint inflammation rather than in nociceptive sensitization in collagen antibody-induced arthritis A.
The present studies indicate that alterations in substance P/NK1 receptor system underlie at least in part the behavioural and monoaminergic changes in this animal model of depression.
By activation of the NK1R receptors it is possible to up-regulate the expression of substance P and NK1R in a protein kinase C mitogen activated protein kinase nuclear factor kappa b dependant pathway.
Blocking NK-1R by an NK-1R antagonist suppressed scratching-induced decreases in substance P-immunoreactive nerve fibers and in neutral endopeptidase activity.
Substance P by acting via NK-1R on various chemokine-secreting cells in the pancreas and lungs stimulates the release of chemokines that aggravate local development of pancreatitis.
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