P30548 · NK1R_MOUSE
- ProteinSubstance-P receptor
- GeneTacr1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids407 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin K.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSubstance-P receptor
- Short namesSPR
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP30548
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-31 | Extracellular | ||||
Sequence: MDNVLPVDSDLFPNTSTNTSESNQFVQPTWQ | ||||||
Transmembrane | 32-54 | Helical; Name=1 | ||||
Sequence: IVLWAAAYTVIVVTSVVGNVVVI | ||||||
Topological domain | 55-64 | Cytoplasmic | ||||
Sequence: WIILAHKRMR | ||||||
Transmembrane | 65-86 | Helical; Name=2 | ||||
Sequence: TVTNYFLVNLAFAEACMAAFNT | ||||||
Topological domain | 87-106 | Extracellular | ||||
Sequence: VVNFTYAVHNVWYYGLFYCK | ||||||
Transmembrane | 107-128 | Helical; Name=3 | ||||
Sequence: FHNFFPIAALFASIYSMTAVAF | ||||||
Topological domain | 129-148 | Cytoplasmic | ||||
Sequence: DRYMAIIHPLQPRLSATATK | ||||||
Transmembrane | 149-169 | Helical; Name=4 | ||||
Sequence: VVIFVIWVLALLLAFPQGYYS | ||||||
Topological domain | 170-194 | Extracellular | ||||
Sequence: TTETMPSRVVCMIEWPEHPNRTYEK | ||||||
Transmembrane | 195-219 | Helical; Name=5 | ||||
Sequence: AYHICVTVLIYFLPLLVIGYAYTVV | ||||||
Topological domain | 220-248 | Cytoplasmic | ||||
Sequence: GITLWASEIPGDSSDRYHEQVSAKRKVVK | ||||||
Transmembrane | 249-270 | Helical; Name=6 | ||||
Sequence: MMIVVVCTFAICWLPFHIFFLL | ||||||
Topological domain | 271-283 | Extracellular | ||||
Sequence: PYINPDLYLKKFI | ||||||
Transmembrane | 284-308 | Helical; Name=7 | ||||
Sequence: QQVYLASMWLAMSSTMYNPIIYCCL | ||||||
Topological domain | 309-407 | Cytoplasmic | ||||
Sequence: NDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEDEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA |
Keywords
- Cellular component
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 22 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, lipidation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000069887 | 1-407 | Substance-P receptor | |||
Sequence: MDNVLPVDSDLFPNTSTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEDEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA | ||||||
Glycosylation | 14 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 18 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 105↔180 | |||||
Sequence: CKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVC | ||||||
Lipidation | 322 | S-palmitoyl cysteine | ||||
Sequence: C |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-20 | Disordered | ||||
Sequence: MDNVLPVDSDLFPNTSTNTS | ||||||
Region | 362-407 | Disordered | ||||
Sequence: VGAHEDEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA | ||||||
Compositional bias | 377-407 | Polar residues | ||||
Sequence: PSSLDLTSNGSSRSNSKTMTESSSFYSNMLA |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length407
- Mass (Da)46,322
- Last updated2011-07-27 v2
- Checksum451B6B875A6659A0
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 377-407 | Polar residues | ||||
Sequence: PSSLDLTSNGSSRSNSKTMTESSSFYSNMLA | ||||||
Sequence conflict | 405 | in Ref. 1; CAA44707 | ||||
Sequence: M → I |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X62934 EMBL· GenBank· DDBJ | CAA44707.1 EMBL· GenBank· DDBJ | mRNA | ||
AK038558 EMBL· GenBank· DDBJ | BAC30042.1 EMBL· GenBank· DDBJ | mRNA | ||
CH466523 EMBL· GenBank· DDBJ | EDK99033.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC075631 EMBL· GenBank· DDBJ | AAH75631.1 EMBL· GenBank· DDBJ | mRNA | ||
BC098332 EMBL· GenBank· DDBJ | AAH98332.1 EMBL· GenBank· DDBJ | mRNA | ||
L27828 EMBL· GenBank· DDBJ | AAA17892.1 EMBL· GenBank· DDBJ | mRNA | ||
L27826 EMBL· GenBank· DDBJ | AAA17891.1 EMBL· GenBank· DDBJ | mRNA |