P30548 · NK1R_MOUSE

  • Protein
    Substance-P receptor
  • Gene
    Tacr1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin K.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell body
Cellular Componentcell periphery
Cellular Componentcell surface
Cellular Componentdendrite
Cellular Componentpostsynaptic membrane
Cellular Componentsperm head
Cellular Componentsperm midpiece
Molecular Functionsubstance P receptor activity
Biological Processaggressive behavior
Biological Processangiotensin-mediated drinking behavior
Biological Processassociative learning
Biological Processbehavioral response to pain
Biological Processeating behavior
Biological Processlong-term memory
Biological Processoperant conditioning
Biological Processpositive regulation of action potential
Biological Processpositive regulation of blood pressure
Biological Processpositive regulation of cytosolic calcium ion concentration
Biological Processpositive regulation of epithelial cell migration
Biological Processpositive regulation of epithelial cell proliferation
Biological Processpositive regulation of flagellated sperm motility
Biological Processpositive regulation of hormone secretion
Biological Processpositive regulation of leukocyte migration
Biological Processpositive regulation of lymphocyte proliferation
Biological Processpositive regulation of ossification
Biological Processpositive regulation of stress fiber assembly
Biological Processpositive regulation of synaptic transmission, cholinergic
Biological Processpositive regulation of synaptic transmission, GABAergic
Biological Processpositive regulation of uterine smooth muscle contraction
Biological Processpositive regulation of vascular permeability
Biological Processpositive regulation of vasoconstriction
Biological Processregulation of smooth muscle cell migration
Biological Processregulation of smooth muscle cell proliferation
Biological Processregulation of uterine smooth muscle contraction
Biological Processresponse to auditory stimulus
Biological Processresponse to electrical stimulus
Biological Processresponse to estradiol
Biological Processresponse to ethanol
Biological Processresponse to nicotine
Biological Processresponse to ozone
Biological Processresponse to pain
Biological Processresponse to progesterone
Biological Processsmooth muscle contraction involved in micturition
Biological Processsperm ejaculation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Substance-P receptor
  • Short names
    SPR
  • Alternative names
    • NK-1 receptor (NK-1R)
    • Tachykinin receptor 1

Gene names

    • Name
      Tacr1
    • Synonyms
      Tac1r

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • CBA/J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P30548
  • Secondary accessions
    • Q8BYR7

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-31Extracellular
Transmembrane32-54Helical; Name=1
Topological domain55-64Cytoplasmic
Transmembrane65-86Helical; Name=2
Topological domain87-106Extracellular
Transmembrane107-128Helical; Name=3
Topological domain129-148Cytoplasmic
Transmembrane149-169Helical; Name=4
Topological domain170-194Extracellular
Transmembrane195-219Helical; Name=5
Topological domain220-248Cytoplasmic
Transmembrane249-270Helical; Name=6
Topological domain271-283Extracellular
Transmembrane284-308Helical; Name=7
Topological domain309-407Cytoplasmic

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 22 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond, lipidation.

TypeIDPosition(s)Description
ChainPRO_00000698871-407Substance-P receptor
Glycosylation14N-linked (GlcNAc...) asparagine
Glycosylation18N-linked (GlcNAc...) asparagine
Disulfide bond105↔180
Lipidation322S-palmitoyl cysteine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with ARRB1.

Protein-protein interaction databases

Chemistry

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-20Disordered
Region362-407Disordered
Compositional bias377-407Polar residues

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    407
  • Mass (Da)
    46,322
  • Last updated
    2011-07-27 v2
  • Checksum
    451B6B875A6659A0
MDNVLPVDSDLFPNTSTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEDEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias377-407Polar residues
Sequence conflict405in Ref. 1; CAA44707

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X62934
EMBL· GenBank· DDBJ
CAA44707.1
EMBL· GenBank· DDBJ
mRNA
AK038558
EMBL· GenBank· DDBJ
BAC30042.1
EMBL· GenBank· DDBJ
mRNA
CH466523
EMBL· GenBank· DDBJ
EDK99033.1
EMBL· GenBank· DDBJ
Genomic DNA
BC075631
EMBL· GenBank· DDBJ
AAH75631.1
EMBL· GenBank· DDBJ
mRNA
BC098332
EMBL· GenBank· DDBJ
AAH98332.1
EMBL· GenBank· DDBJ
mRNA
L27828
EMBL· GenBank· DDBJ
AAA17892.1
EMBL· GenBank· DDBJ
mRNA
L27826
EMBL· GenBank· DDBJ
AAA17891.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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