P30543 · AA2AR_RAT
- ProteinAdenosine receptor A2a
- GeneAdora2a
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids410 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Receptor for adenosine (By similarity).
The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:23994616).
The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:23994616).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 164 | adenosine (UniProtKB | ChEBI); agonist | |||
Binding site | 248 | adenosine (UniProtKB | ChEBI); agonist | |||
Binding site | 272 | adenosine (UniProtKB | ChEBI); agonist | |||
Binding site | 273 | adenosine (UniProtKB | ChEBI); agonist | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosine receptor A2a
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionP30543
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Note: Colocalizes with GAS2L2 at neuronal processes.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-4 | Extracellular | |||
Transmembrane | 5-29 | Helical; Name=1 | |||
Topological domain | 30-39 | Cytoplasmic | |||
Transmembrane | 40-63 | Helical; Name=2 | |||
Topological domain | 64-74 | Extracellular | |||
Transmembrane | 75-97 | Helical; Name=3 | |||
Topological domain | 98-117 | Cytoplasmic | |||
Transmembrane | 118-140 | Helical; Name=4 | |||
Topological domain | 141-168 | Extracellular | |||
Transmembrane | 169-193 | Helical; Name=5 | |||
Topological domain | 194-229 | Cytoplasmic | |||
Transmembrane | 230-253 | Helical; Name=6 | |||
Topological domain | 254-261 | Extracellular | |||
Transmembrane | 262-285 | Helical; Name=7 | |||
Topological domain | 286-410 | Cytoplasmic | |||
Keywords
- Cellular component
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000069001 | 1-410 | Adenosine receptor A2a | ||
Disulfide bond | 68↔154 | ||||
Disulfide bond | 71↔143 | ||||
Disulfide bond | 74↔161 | ||||
Glycosylation | 142 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 149 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 254↔257 | ||||
Post-translational modification
Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface (By similarity).
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct (By similarity).
May interact with DRD4 (By similarity).
Interacts with NECAB2 (By similarity).
Interacts (via cytoplasmic C-terminal domain) with GAS2L2; interaction enhances receptor-mediated adenylyl cyclase activity (PubMed:23994616).
May interact with DRD4 (By similarity).
Interacts with NECAB2 (By similarity).
Interacts (via cytoplasmic C-terminal domain) with GAS2L2; interaction enhances receptor-mediated adenylyl cyclase activity (PubMed:23994616).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P30543 | Cnr1 P20272 | 3 | EBI-2902822, EBI-2909800 | |
XENO | P30543 | Tsnax Q9QZE7 | 6 | EBI-2902822, EBI-2910751 |
Protein-protein interaction databases
Chemistry
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 322-410 | Interaction with GAS2L2 | |||
Region | 344-410 | Disordered | |||
Domain
The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length410
- Mass (Da)44,999
- Last updated2000-12-01 v2
- MD5 ChecksumFF6F104B125CDB6EFAC0F0F3B66EC58E
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 268 | in Ref. 1; AAA70305 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M91214 EMBL· GenBank· DDBJ | AAA70305.2 EMBL· GenBank· DDBJ | mRNA | ||
L08102 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
S47609 EMBL· GenBank· DDBJ | AAA11888.1 EMBL· GenBank· DDBJ | mRNA | ||
AF228684 EMBL· GenBank· DDBJ | AAF61924.1 EMBL· GenBank· DDBJ | mRNA | ||
BC081727 EMBL· GenBank· DDBJ | AAH81727.1 EMBL· GenBank· DDBJ | mRNA |