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P30543 · AA2AR_RAT

  • Protein
    Adenosine receptor A2a
  • Gene
    Adora2a
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Receptor for adenosine (By similarity).
The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:23994616).

Features

Showing features for binding site.

141050100150200250300350400
TypeIDPosition(s)Description
Binding site164adenosine (UniProtKB | ChEBI); agonist
Binding site248adenosine (UniProtKB | ChEBI); agonist
Binding site272adenosine (UniProtKB | ChEBI); agonist
Binding site273adenosine (UniProtKB | ChEBI); agonist

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentasymmetric synapse
Cellular Componentaxolemma
Cellular Componentaxon
Cellular Componentdendrite
Cellular Componentglutamatergic synapse
Cellular ComponentGolgi membrane
Cellular Componentintermediate filament
Cellular Componentmembrane
Cellular Componentneuronal cell body
Cellular Componentplasma membrane
Cellular Componentpostsynaptic membrane
Cellular Componentpresynaptic active zone
Cellular Componentpresynaptic membrane
Molecular Functionalpha-actinin binding
Molecular Functioncalmodulin binding
Molecular Functionenzyme binding
Molecular FunctionG protein-coupled adenosine receptor activity
Molecular Functionidentical protein binding
Molecular Functionlipid binding
Molecular Functionprotein-containing complex binding
Molecular Functiontype 5 metabotropic glutamate receptor binding
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processapoptotic signaling pathway
Biological Processastrocyte activation
Biological Processeating behavior
Biological Processexcitatory postsynaptic potential
Biological ProcessG protein-coupled adenosine receptor signaling pathway
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processinhibitory postsynaptic potential
Biological Processlocomotory behavior
Biological Processmembrane depolarization
Biological Processnegative regulation of alpha-beta T cell activation
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of inflammatory response
Biological Processnegative regulation of neuron apoptotic process
Biological Processnegative regulation of vascular permeability
Biological Processneuron projection morphogenesis
Biological Processpositive regulation of acetylcholine secretion, neurotransmission
Biological Processpositive regulation of apoptotic signaling pathway
Biological Processpositive regulation of circadian sleep/wake cycle, sleep
Biological Processpositive regulation of glutamate secretion
Biological Processpositive regulation of long-term synaptic potentiation
Biological Processpositive regulation of protein secretion
Biological Processpositive regulation of synaptic transmission, GABAergic
Biological Processpositive regulation of synaptic transmission, glutamatergic
Biological Processpositive regulation of urine volume
Biological Processprepulse inhibition
Biological Processpresynaptic modulation of chemical synaptic transmission
Biological Processregulation of calcium ion transport
Biological Processregulation of DNA-templated transcription
Biological Processregulation of mitochondrial membrane potential
Biological Processregulation of norepinephrine secretion
Biological Processresponse to alkaloid
Biological Processresponse to amphetamine
Biological Processresponse to caffeine
Biological Processresponse to purine-containing compound
Biological Processresponse to xenobiotic stimulus
Biological Processsynaptic transmission, cholinergic
Biological Processsynaptic transmission, dopaminergic
Biological Processsynaptic transmission, glutamatergic
Biological Processvasodilation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenosine receptor A2a

Gene names

    • Name
      Adora2a

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P30543

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-4Extracellular
Transmembrane5-29Helical; Name=1
Topological domain30-39Cytoplasmic
Transmembrane40-63Helical; Name=2
Topological domain64-74Extracellular
Transmembrane75-97Helical; Name=3
Topological domain98-117Cytoplasmic
Transmembrane118-140Helical; Name=4
Topological domain141-168Extracellular
Transmembrane169-193Helical; Name=5
Topological domain194-229Cytoplasmic
Transmembrane230-253Helical; Name=6
Topological domain254-261Extracellular
Transmembrane262-285Helical; Name=7
Topological domain286-410Cytoplasmic

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for chain, disulfide bond, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00000690011-410Adenosine receptor A2a
Disulfide bond68↔154
Disulfide bond71↔143
Disulfide bond74↔161
Glycosylation142N-linked (GlcNAc...) asparagine
Glycosylation149N-linked (GlcNAc...) asparagine
Disulfide bond254↔257

Post-translational modification

Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface (By similarity).

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in striatal neurons (at protein level).

Gene expression databases

Interaction

Subunit

Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct (By similarity).
May interact with DRD4 (By similarity).
Interacts with NECAB2 (By similarity).
Interacts (via cytoplasmic C-terminal domain) with GAS2L2; interaction enhances receptor-mediated adenylyl cyclase activity (PubMed:23994616).

Binary interactions

Type
Entry 1Entry 2Number of experimentsIntAct
BINARY P30543Cnr1 P202723EBI-2902822, EBI-2909800
XENO P30543Tsnax Q9QZE76EBI-2902822, EBI-2910751

Protein-protein interaction databases

Chemistry

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region322-410Interaction with GAS2L2
Region344-410Disordered

Domain

The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    410
  • Mass (Da)
    44,999
  • Last updated
    2000-12-01 v2
  • MD5 Checksum
    FF6F104B125CDB6EFAC0F0F3B66EC58E
MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGLGGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict268in Ref. 1; AAA70305

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M91214
EMBL· GenBank· DDBJ
AAA70305.2
EMBL· GenBank· DDBJ
mRNA
L08102
EMBL· GenBank· DDBJ
-mRNA No translation available.
S47609
EMBL· GenBank· DDBJ
AAA11888.1
EMBL· GenBank· DDBJ
mRNA
AF228684
EMBL· GenBank· DDBJ
AAF61924.1
EMBL· GenBank· DDBJ
mRNA
BC081727
EMBL· GenBank· DDBJ
AAH81727.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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