P30440 · FEL1B_FELCA

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Major allergen I polypeptide chain 2
  • Alternative names
    • AG4
    • Allergen Cat-1
    • Allergen Fel d I-B (Allergen FdI)
  • Allergen name
    Fel d 1-B

Gene names

    • Name
      CH2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    P30440

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

Allergenic properties

Causes an allergic reaction in human. Binds to IgE. Major allergen produced by the domestic cat. Implicated as an asthma-inducing agent in human. This protein is sticky and easily adheres to walls, carpet, clothing, furniture and bedding.

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant72in CH2LV
Natural variant72in CH2SV
Natural variant74-75in CH2SV
Natural variant91in CH2LV
Natural variant96in CH2SV
Natural variant105in CH2SV

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 6 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Protein family/group databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-17
ChainPRO_000002124818-109Major allergen I polypeptide chain 2
Disulfide bond24Interchain (with C-92 in chain 1)
Glycosylation50N-linked (GlcNAc...) asparagine
Disulfide bond65Interchain (with C-66 in chain 1)
Disulfide bond90Interchain (with C-25 in chain 1)

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

The long form is preferentially expressed in the salivary gland, while the short form is preferentially expressed in the skin.

Interaction

Subunit

Heterotetramer composed of two non-covalently linked disulfide-linked heterodimer of chains 1 and 2.

Family & Domains

Sequence similarities

Belongs to the secretoglobin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 3 isoforms produced by Alternative splicing. Experimental confirmation may be lacking for some isoforms.

P30440-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    CH2L
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    109
  • Mass (Da)
    11,854
  • Last updated
    1993-04-01 v1
  • Checksum
    857FB9CD76036CB9
MRGALLVLALLVTQALGVKMAETCPIFYDVFFAVANGNELLLDLSLTKVNATEPERTAMKKIQDCYVENGLISRVLDGLVMTTISSSKDCMGEAVQNTVEDLKLNTLGR

P30440-2

  • Name
    2
  • Synonyms
    CH2S
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P30440-3

  • Name
    3
  • Synonyms
    CH2ST, Truncated
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 82-109: TTISSSKDCMGEAVQNTVEDLKLNTLGR → PSTNIAWVKQFRTP

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict24in Ref. 3; AA sequence
Sequence conflict32in Ref. 3; AA sequence
Alternative sequenceVSP_00424982-89in isoform 2
Alternative sequenceVSP_00424882-109in isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M77341
EMBL· GenBank· DDBJ
AAC41616.1
EMBL· GenBank· DDBJ
mRNA
X62478
EMBL· GenBank· DDBJ
CAA44345.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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