P29997 · SHDAG_HDVWO

Function

function

Promotes both transcription and replication of genomic RNA. Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. May interact with host RNA polymerase II thereby changing its template requirement from DNA to RNA. RNA pol II complex would then acts as an RNA-directed RNA polymerase, and transcribe and replicate HDV genome (By similarity).

Miscellaneous

This strain belongs to the genotype I found in North America, Europe, Africa, East and West Asia and the South Pacific.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell
Cellular Componenthost cell nucleus
Cellular Componentvirion component
Molecular FunctionRNA binding
Biological Processsymbiont entry into host cell
Biological Processviral penetration into host nucleus

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Small delta antigen
  • Short names
    S-HDAg
  • Alternative names
    • p24

Organism names

Accessions

  • Primary accession
    P29997
  • Secondary accessions
    • Q999V2
    • Q999V3

Proteomes

Subcellular Location

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant11in strain: Isolate Woodchuck5
Natural variant86in strain: Isolate Woodchuck5
Natural variant96in strain: Isolate Woodchuck5

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 3 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000381591-195Small delta antigen
Modified residue2Phosphoserine; by host CK2
Modified residue13Omega-N-methylated arginine; by host PRMT1
Modified residue72N6-acetyllysine; by host
Modified residue123Phosphoserine; by host
Modified residue177Phosphoserine; by host MAPK1 and MAPK3
Modified residue182Phosphothreonine; by host

Post-translational modification

Phosphorylated at serines and threonines by host MAPK1/3, PKR, and CK2.
Acetylation modulates nuclear localization. Neo-synthesized genomic RNA migrates from the nucleus to the cytoplasm, where they interact with S-HDAg, which once acetylated redirect both partners to the nucleus (By similarity).
Methylation plays a role in viral genome replication.

Keywords

Interaction

Subunit

Homodimer. Homooctamer. Interacts with host RNA polymerase II complex, and with host NPM1.

Structure

3D structure databases

Family & Domains

Features

Showing features for region, domain, compositional bias, motif.

TypeIDPosition(s)Description
Region12-60Dimerization
Domain20-195HDAg
Region45-195Disordered
Compositional bias57-105Basic and acidic residues
Motif66-75Nuclear localization signal
Region97-107RNA-binding
Compositional bias118-145Basic and acidic residues
Region130-195RNAPII-binding
Region136-146RNA-binding

Sequence similarities

Belongs to the hepatitis delta antigen family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    195
  • Mass (Da)
    21,895
  • Last updated
    2009-04-14 v3
  • Checksum
    2798B67BCEF16B44
MSRSESRKNRGGREEILEQWVAGRKKLEELERDLRKTKKKLKKIEDENPWLGNIKGILGKKDKDGEGAPPAKRARTDQMEVDSGPRKRPLRGGFTDKERQDHRRRKALENKKKQLSAGGKNLSKEEEEELRRLTEEDERRERRVAGPPVGGVNPLEGGSRGAPGGGFVPNLQGVPESPFSRTGEGLDIRGNQGFP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias57-105Basic and acidic residues
Compositional bias118-145Basic and acidic residues

RNA Editing

Edited at position 196
Partially edited. RNA editing at this position occurs on the antigenomic strand and consists of a conversion of A to G catalyzed by the cellular enzyme ADAR1. The unedited RNA version gives rise to the small delta antigen, which ends with a nonsense codon at position 196. In the edited version, this amber codon is modified to a tryptophan codon and gives rise to the large delta antigen protein (AC P0C6M9). S-HDAg suppresses editing of non-replicating antigenomic RNA, thereby regulating the extent of editing (By similarity)

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M21012
EMBL· GenBank· DDBJ
AAA45723.1
EMBL· GenBank· DDBJ
Genomic RNA
AJ307077
EMBL· GenBank· DDBJ
CAC32837.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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