P29951 · MPI_EMENI

Function

function

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site107Zn2+ (UniProtKB | ChEBI)
Binding site109Zn2+ (UniProtKB | ChEBI)
Binding site134Zn2+ (UniProtKB | ChEBI)
Binding site291Zn2+ (UniProtKB | ChEBI)
Active site310

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmannose-6-phosphate isomerase activity
Molecular Functionzinc ion binding
Biological Processcarbohydrate metabolic process
Biological Processcell wall mannoprotein biosynthetic process
Biological ProcessGDP-mannose biosynthetic process
Biological Processprotein glycosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mannose-6-phosphate isomerase
  • EC number
  • Alternative names
    • Phosphohexomutase
    • Phosphomannose isomerase (PMI)

Gene names

    • Name
      manA
    • ORF names
      AN0667

Organism names

Accessions

  • Primary accession
    P29951
  • Secondary accessions
    • C8VRS9
    • Q5BFL3

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001942441-461Mannose-6-phosphate isomerase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    461
  • Mass (Da)
    50,613
  • Last updated
    2007-05-01 v2
  • Checksum
    17E0D089A6656F79
MQVPLLRLQCGVNSYDWGRVGPESAAAKYAAATAPSDFTIEADKPYAELWMGTHPSLPSKDVETQRTLLDMVQDNLALMSPEVSERYGGKLPFLFKVLSIRKALSIQAHPNKKLAEALHARDPRNYPDDNHKPEMTIAITPFEGLCGFRPLAEIVHFLKAVAPLRYLIGVQTATDFENAVRGFENTEDPEQTKKNKVALRTLFTSLMQSASENIEQAARELVAAAQSSPETFASLVNAPDTNPTNAAELASIIIRLNEQFPNDIGLFVFFFLNFVRLEPGEAMFLKADDIHAYISGDIIECMASSDNVVRAGFTPKFKDVDTLTEMLTYSYAPIDEQKLQPTDYPYTVLNAAAYSSASDSLLYDPPIEEFSVVKTSLRRTGAKATFDPLTGPSILICTGGTGKISVGHKTEEVKEGYVFFVGANAECIIENTGTGSDEENVFTTFKAFCDLTGKEDMANGH

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict19in Ref. 1; AAA33319

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M85239
EMBL· GenBank· DDBJ
AAA33319.1
EMBL· GenBank· DDBJ
Genomic DNA
AACD01000010
EMBL· GenBank· DDBJ
EAA65443.1
EMBL· GenBank· DDBJ
Genomic DNA
BN001308
EMBL· GenBank· DDBJ
CBF89025.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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