P29951 · MPI_EMENI
- ProteinMannose-6-phosphate isomerase
- GenemanA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids461 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Catalytic activity
- D-mannose 6-phosphate = D-fructose 6-phosphate
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | mannose-6-phosphate isomerase activity | |
Molecular Function | zinc ion binding | |
Biological Process | carbohydrate metabolic process | |
Biological Process | cell wall mannoprotein biosynthetic process | |
Biological Process | GDP-mannose biosynthetic process | |
Biological Process | protein glycosylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMannose-6-phosphate isomerase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Nidulantes
Accessions
- Primary accessionP29951
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000194244 | 1-461 | Mannose-6-phosphate isomerase | |||
Sequence: MQVPLLRLQCGVNSYDWGRVGPESAAAKYAAATAPSDFTIEADKPYAELWMGTHPSLPSKDVETQRTLLDMVQDNLALMSPEVSERYGGKLPFLFKVLSIRKALSIQAHPNKKLAEALHARDPRNYPDDNHKPEMTIAITPFEGLCGFRPLAEIVHFLKAVAPLRYLIGVQTATDFENAVRGFENTEDPEQTKKNKVALRTLFTSLMQSASENIEQAARELVAAAQSSPETFASLVNAPDTNPTNAAELASIIIRLNEQFPNDIGLFVFFFLNFVRLEPGEAMFLKADDIHAYISGDIIECMASSDNVVRAGFTPKFKDVDTLTEMLTYSYAPIDEQKLQPTDYPYTVLNAAAYSSASDSLLYDPPIEEFSVVKTSLRRTGAKATFDPLTGPSILICTGGTGKISVGHKTEEVKEGYVFFVGANAECIIENTGTGSDEENVFTTFKAFCDLTGKEDMANGH |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length461
- Mass (Da)50,613
- Last updated2007-05-01 v2
- Checksum17E0D089A6656F79
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 19 | in Ref. 1; AAA33319 | ||||
Sequence: R → K |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M85239 EMBL· GenBank· DDBJ | AAA33319.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AACD01000010 EMBL· GenBank· DDBJ | EAA65443.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BN001308 EMBL· GenBank· DDBJ | CBF89025.1 EMBL· GenBank· DDBJ | Genomic DNA |