P29932 · COBQ_SINSX

  • Protein
    Cobyric acid synthase
  • Gene
    cobQ
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

Caution

Was originally thought to originate from Pseudomonas denitrificans, but similarity searches show that the sequence is much closer to Sinorhizobium. The entry's taxonomy has been changed.

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis.

Features

Showing features for active site.

148550100150200250300350400450
TypeIDPosition(s)Description
Active site333Nucleophile
Active site430

GO annotations

AspectTerm
Molecular FunctionABC-type vitamin B12 transporter activity
Molecular Functioncatalytic activity
Biological Processcobalamin biosynthetic process
Biological Processglutamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cobyric acid synthase

Gene names

    • Name
      cobQ

Organism names

  • Taxonomic identifier
  • Strain
    • SC510
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Rhizobiaceae > Sinorhizobium/Ensifer group > Sinorhizobium

Accessions

  • Primary accession
    P29932

PTM/Processing

Features

Showing features for initiator methionine, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00001413212-485Cobyric acid synthase

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain251-438GATase cobBQ-type

Sequence similarities

Belongs to the CobB/CobQ family. CobQ subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    485
  • Mass (Da)
    51,982
  • Last updated
    2007-01-23 v3
  • Checksum
    FC2E5E15657016A9
MTRRIMLQGTGSDVGKSVLVAGLCRLAANQGLKVRPFKPQNMSNNAAVSDDGGEIGRAQWLQALAARVPSSVHMNPVLLKPQSDVGSQIVVQGKVAGQARGREYQALKPKLLGAVMESFEQISAGADLVVVEGAGSPAEINLRPGDIANMGFATRANVPVVLVGDIDRGGVIASLVGTHAILPEEDRRMVTGYLINKFRGDVTLFDDGIAAVNRYTGWPCFGVVPWLKAAARLPAEDSVVLEKLTRGEGRALKVAVPVLSRIANFDDLDPLAAEPEIDLVFVRPGSPIPVDAGLVVIPGSKSTIGDLIDFRAQGWDRDLERHVRRGGRVIGICGGYQMLGRRVTDPLGIEGGERAVEGLGLLEVETEMAPEKTVRNSRAWSLEHDVVLEGYEIHLGKTQGADCGRPSVRIDNRADGALSADGRVMGTYLHGLFTSDAYRGALLKSFGIEGGANNYRQSVDAALDDVANELEAVLDRRWLDELLRH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M62866
EMBL· GenBank· DDBJ
AAA25777.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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