P29932 · COBQ_SINSX
- ProteinCobyric acid synthase
- GenecobQ
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids485 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
Pathway
Cofactor biosynthesis; adenosylcobalamin biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 333 | Nucleophile | ||||
Sequence: C | ||||||
Active site | 430 | |||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ABC-type vitamin B12 transporter activity | |
Molecular Function | catalytic activity | |
Biological Process | cobalamin biosynthetic process | |
Biological Process | glutamine metabolic process |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCobyric acid synthase
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Rhizobiaceae > Sinorhizobium/Ensifer group > Sinorhizobium
Accessions
- Primary accessionP29932
PTM/Processing
Features
Showing features for initiator methionine, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Chain | PRO_0000141321 | 2-485 | Cobyric acid synthase | |||
Sequence: TRRIMLQGTGSDVGKSVLVAGLCRLAANQGLKVRPFKPQNMSNNAAVSDDGGEIGRAQWLQALAARVPSSVHMNPVLLKPQSDVGSQIVVQGKVAGQARGREYQALKPKLLGAVMESFEQISAGADLVVVEGAGSPAEINLRPGDIANMGFATRANVPVVLVGDIDRGGVIASLVGTHAILPEEDRRMVTGYLINKFRGDVTLFDDGIAAVNRYTGWPCFGVVPWLKAAARLPAEDSVVLEKLTRGEGRALKVAVPVLSRIANFDDLDPLAAEPEIDLVFVRPGSPIPVDAGLVVIPGSKSTIGDLIDFRAQGWDRDLERHVRRGGRVIGICGGYQMLGRRVTDPLGIEGGERAVEGLGLLEVETEMAPEKTVRNSRAWSLEHDVVLEGYEIHLGKTQGADCGRPSVRIDNRADGALSADGRVMGTYLHGLFTSDAYRGALLKSFGIEGGANNYRQSVDAALDDVANELEAVLDRRWLDELLRH |
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 251-438 | GATase cobBQ-type | ||||
Sequence: ALKVAVPVLSRIANFDDLDPLAAEPEIDLVFVRPGSPIPVDAGLVVIPGSKSTIGDLIDFRAQGWDRDLERHVRRGGRVIGICGGYQMLGRRVTDPLGIEGGERAVEGLGLLEVETEMAPEKTVRNSRAWSLEHDVVLEGYEIHLGKTQGADCGRPSVRIDNRADGALSADGRVMGTYLHGLFTSDAY |
Sequence similarities
Belongs to the CobB/CobQ family. CobQ subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length485
- Mass (Da)51,982
- Last updated2007-01-23 v3
- ChecksumFC2E5E15657016A9
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M62866 EMBL· GenBank· DDBJ | AAA25777.1 EMBL· GenBank· DDBJ | Genomic DNA |