P29913 · NQO1_PARDE

  • Protein
    NADH-quinone oxidoreductase chain 1
  • Gene
    nqo1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site54-63NAD+ (UniProtKB | ChEBI)
Binding site167-214FMN (UniProtKB | ChEBI)
Binding site346[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site349[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site352[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site392[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Cellular Componentrespiratory chain complex I
Molecular Function4 iron, 4 sulfur cluster binding
Molecular FunctionFMN binding
Molecular Functionmetal ion binding
Molecular FunctionNAD binding
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular Functionquinone binding

Keywords

Enzyme and pathway databases

Protein family/group databases

    • 3.D.1.2.1the h+ or na+-translocating nadh dehydrogenase (ndh) family

Names & Taxonomy

Protein names

  • Recommended name
    NADH-quinone oxidoreductase chain 1
  • EC number
  • Alternative names
    • NADH dehydrogenase I, chain 1
    • NDH-1, chain 1

Gene names

    • Name
      nqo1

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 13543 / NRRL B-3784 / NRC 449
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Paracoccaceae > Paracoccus

Accessions

  • Primary accession
    P29913

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001185661-431NADH-quinone oxidoreductase chain 1

Keywords

Interaction

Subunit

NDH-1 is composed of at least 14 different subunits, Nqo1 to Nqo14. The complex has a L-shaped structure, with the hydrophobic arm (subunits Nqo7, Nqo8, Nqo10 to Nqo14) embedded in the inner membrane and the hydrophilic peripheral arm (subunits Nqo1 to Nqo6, Nqo9) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers.

Structure

Family & Domains

Sequence similarities

Belongs to the complex I 51 kDa subunit family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    431
  • Mass (Da)
    47,191
  • Last updated
    1993-04-01 v1
  • Checksum
    AA25C5A0A7570048
MLNDQDRIFTNLYGMGDRSLAGAKKRGHWDGTAAIIQRGRDKIIDEMKASGLRGRGGAGFPTGMKWSFMPKESDGRPSYLVINADESEPATCKDREIMRHDPHTLIEGALIASFAMGAHAAYIYIRGEFIREREALQAAIDECYDAGLLGRNAAGSGWDFDLYLHHGAGAYICGEETALLESLEGKKGMPRMKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGAEWFASFGRPNNAGVKLFGLTGHVNTPCVVEEAMSIPMRELIEKHGGGIRGGWKNLKAVIPGGASCPVLTAEQCENAIMDYDGMRDVRSSFGTACMIVMDQSTDVVKAIWRLSKFFKHESCGQCTPCREGTGWMMRVMERLVRGDAEVEEIDMLFDVTKQVEGHTICALGDAAAWPIQGLIRNFREEIEDRIKAKRTGRMGAMAAE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M64432
EMBL· GenBank· DDBJ
AAA25585.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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