P29847 · CYSE_SALTY
- ProteinSerine acetyltransferase
- GenecysE
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids273 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- acetyl-CoA + L-serine = CoA + O-acetyl-L-serine
Activity regulation
Sensitive to feedback inhibition by L-cysteine.
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
6.9 mM | L-serine as isolated subunit | |||||
7.4 mM | L-serine in complex with CysK | |||||
1.2 mM | acetyl-CoA as isolated subunit and in complex with CysK |
Pathway
Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | serine O-acetyltransferase activity | |
Biological Process | cysteine biosynthetic process from serine |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine acetyltransferase
- EC number
- Short namesSAT
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionP29847
Proteomes
Subcellular Location
Phenotypes & Variants
Miscellaneous
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000068672 | 1-273 | Serine acetyltransferase | |||
Sequence: MPCEELEIVWKNIKAEARALADCEPMLASFYHATLLKHENLGSALSYMLANKLASPIMPAIAIREVVEEAYAADPEMIASAACDIQAVRTRDPAVDKYSTPLLYLKGFHALQAYRIGHWLWNKGRRALAIFLQNQVSVSFQVDIHPAAKIGRGIMLDHATGIVVGETAVIEDDVSILQSVTLGGTGKTSGDRHPKIREGVMIGAGAKILGNIEVGRGAKIGAGSVVLQPVPPHTTAAGVPARIVGKPGSDKPSMDMDQHFNGIHHTFEYGDGI |
Proteomic databases
Interaction
Subunit
Part of the cysteine synthase complex formed at a ratio of 1 copy of this protein and 2 copies of O-acetylserine sulfhydrylase (cysK). The complex reversibly dissociates in the presence of O-acetyl-L-serine in the absence of hydrogen sulfide.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length273
- Mass (Da)29,291
- Last updated1993-04-01 v1
- Checksum6A5736E656FBD25B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X59594 EMBL· GenBank· DDBJ | CAA42163.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
A00198 EMBL· GenBank· DDBJ | CAA00039.1 EMBL· GenBank· DDBJ | Unassigned DNA | ||
AE006468 EMBL· GenBank· DDBJ | AAL22558.1 EMBL· GenBank· DDBJ | Genomic DNA |