P29620 · CDKD1_ORYSJ

Function

function

CDK-activating kinase that may control G1/S phase progression. May control the rate of cell differentiation to accomplish proper development of organs, or in response to a changing environment. Forms a complex with cyclin CYCH1-1 that phosphorylates CDKA-1 and the C-terminal domain (CTD) of the large subunit of RNA polymerase II.

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site25-33ATP (UniProtKB | ChEBI)
Binding site48ATP (UniProtKB | ChEBI)
Active site141Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Cellular Componenttranscription factor TFIIK complex
Molecular FunctionATP binding
Molecular Functioncyclin-dependent protein serine/threonine kinase activity
Molecular Functionprotein serine kinase activity
Molecular FunctionRNA polymerase II CTD heptapeptide repeat kinase activity
Biological Processcell division
Biological Processpositive regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cyclin-dependent kinase D-1
  • EC number
  • Short names
    CDKD;1
  • Alternative names
    • CDC2+/CDC28-related protein kinase R2
    • CDK-activating kinase R2 (CAK-R2)

Gene names

    • Name
      CDKD-1
    • Synonyms
      R2
    • ORF names
      OJ1764_D01.12
    • Ordered locus names
      Os05g0392300, LOC_Os05g32600

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Nipponbare
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa

Accessions

  • Primary accession
    P29620
  • Secondary accessions
    • Q0DIF9
    • Q60ES0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00000860741-424UniProtCyclin-dependent kinase D-1
Modified residue29UniProtPhosphothreonine
Modified residue30UniProtPhosphotyrosine
Modified residue168UniProtPhosphoserine
Modified residue (large scale data)168PTMeXchangePhosphoserine
Modified residue174UniProtPhosphothreonine
Modified residue (large scale data)174PTMeXchangePhosphothreonine
Modified residue (large scale data)338PTMeXchangePhosphoserine

Keywords

Proteomic databases

Expression

Tissue specificity

Expressed in actively dividing cells of roots, leaves and shoots. Expressed in the intercalary meristem and the elongation zone of internodes.

Induction

By gibberellic acid (GA3) and submergence in the meristematic zone of internodes. Down-regulated by auxin.

Developmental stage

Expression reaches a peak in the G1/S phases and then decreases in the G2/M phases.

Interaction

Subunit

Interacts with CYCH1-1.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain19-299Protein kinase
Region303-337Disordered
Region359-424Disordered
Compositional bias405-424Basic and acidic residues

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    424
  • Mass (Da)
    47,613
  • Last updated
    1993-04-01 v1
  • Checksum
    28606BE7120BB048
MASGDGGDDAGVKRVADRYLKREVLGEGTYGVVFKAVDTKTGNTVAIKKIRLGKYKEGVNFTALREIKLLKELKDSNIIELIDAFPYKGNLHLVFEFMETDLEAVIRDRNIVLSPADTKSYIQMMLKGLAFCHKKWVLHRDMKPNNLLIGADGQLKLADFGLARIFGSPERNFTHQVFARWYRAPELLFGTKQYGSAVDIWAAGCIFAELLLRRPFLQGSSDIDQLGKIFAAFGTPKSSQWPDMVYLPDYVEYQFVSAPPLRSLFPMASDDALDLLSRMFTYDPKARITAQQALEHRYFLSVPAPTKPSQLPRPPPKGDSGNNKIPDLNLQDGPVVLSPPRKLRRVTAHEGMEVHMHRADRTEEHPSGARHMDDMSSQSSRIPMSVDVGAIFGTRPAPRPTLNSADKSRLKRKLDMDPEFGYTE

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0P0WLZ1A0A0P0WLZ1_ORYSJOs05g0392300147
B7F5K0B7F5K0_ORYSJOs05g0392300279

Sequence caution

The sequence AAV31263.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias405-424Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X58194
EMBL· GenBank· DDBJ
CAA41172.1
EMBL· GenBank· DDBJ
mRNA
AC107085
EMBL· GenBank· DDBJ
AAV31263.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AP008211
EMBL· GenBank· DDBJ
BAF17364.1
EMBL· GenBank· DDBJ
Genomic DNA
AP014961
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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