P29619 · CDKA2_ORYSJ
- ProteinCyclin-dependent kinase A-2
- GeneCDKA-2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids292 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cyclin-dependent protein kinase holoenzyme complex | |
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Cellular Component | NuRD complex | |
Molecular Function | ATP binding | |
Molecular Function | cyclin binding | |
Molecular Function | cyclin-dependent protein serine/threonine kinase activity | |
Molecular Function | protein serine kinase activity | |
Molecular Function | RNA polymerase II CTD heptapeptide repeat kinase activity | |
Biological Process | G1/S transition of mitotic cell cycle | |
Biological Process | regulation of G2/M transition of mitotic cell cycle | |
Biological Process | regulation of gene expression | |
Biological Process | regulation of meiotic cell cycle | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCyclin-dependent kinase A-2
- EC number
- Short namesCDKA;2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa
Accessions
- Primary accessionP29619
- Secondary accessions
Proteomes
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000085756 | 1-292 | UniProt | Cyclin-dependent kinase A-2 | |||
Sequence: MEQYEKVEKIGEGTYGVVYKGKHRHTNETIALKKIRLEQEDEGVPSTAIREISLLKEMQHRNIVRLQDVVHKEKCIYLVFEYLDLDLKKHMDSSPDFKNHRIVKSFLYQILRGIAYCHSHRVLHRDLKPQNLLIDRRTNSLKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGARHYSTPVDMWSVGCIFAEMVNQKPLFPGDSEIDELFKIFSIMGTPNEETWPGVASLPDYISTFPKWPSVDLATVVPTLDSSGLDLLSKMLRLDPSKRINARAALEHEYFKDLEVA | |||||||
Modified residue | 14 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 15 | UniProt | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 158 | PTMeXchange | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 160 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 160 | PTMeXchange | Phosphothreonine | ||||
Sequence: T |
Keywords
- PTM
Proteomic databases
Expression
Tissue specificity
Expressed in the dividing region of the root apex and in differentiated cells such as those in the sclerenchyma, pericycle and parenchyma of the central cylinder. Expressed in the intercalary meristem and the elongation zone of internodes.
Induction
By gibberellic acid (GA3) and submergence. Down-regulated by auxin.
Developmental stage
Expression reaches a peak in the G1/S phases and then decreases in the G2/M phases.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-286 | Protein kinase | ||||
Sequence: YEKVEKIGEGTYGVVYKGKHRHTNETIALKKIRLEQEDEGVPSTAIREISLLKEMQHRNIVRLQDVVHKEKCIYLVFEYLDLDLKKHMDSSPDFKNHRIVKSFLYQILRGIAYCHSHRVLHRDLKPQNLLIDRRTNSLKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGARHYSTPVDMWSVGCIFAEMVNQKPLFPGDSEIDELFKIFSIMGTPNEETWPGVASLPDYISTFPKWPSVDLATVVPTLDSSGLDLLSKMLRLDPSKRINARAALEHEYF |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length292
- Mass (Da)33,693
- Last updated1993-04-01 v1
- ChecksumC7791576349DFE22
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
B7E9N8 | B7E9N8_ORYSJ | Os02g0123100 | 376 | ||
A0A0N7KEL2 | A0A0N7KEL2_ORYSJ | Os02g0123100 | 144 |
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X60375 EMBL· GenBank· DDBJ | CAA42923.1 EMBL· GenBank· DDBJ | mRNA | ||
AP004885 EMBL· GenBank· DDBJ | BAD07949.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP004885 EMBL· GenBank· DDBJ | BAD07950.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AP008208 EMBL· GenBank· DDBJ | BAF07645.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP014958 EMBL· GenBank· DDBJ | BAS76730.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK101344 EMBL· GenBank· DDBJ | BAG95020.1 EMBL· GenBank· DDBJ | mRNA |