TYK2, prototype of a novel class of non-receptor tyrosine kinase genes.Firmbach-Kraft I., Byers M., Shows T., Dalla-Favera R., Krolewski J.J.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA], VARIANTS PHE-362 AND SER-684CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCOncogene 5:1329-1336 (1990)Cited in1
No title available.SeattleSNPs variation discovery resourceCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-4; HIS-197; PHE-362; SER-363 AND SER-684CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (FEB-2004)Cited in2
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project TeamView abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]TissueKidneyCategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenome Res. 14:2121-2127 (2004)Cited in99+99+
A protein tyrosine kinase in the interferon alpha/beta signaling pathway.Velazquez L., Fellous M., Stark G.R., Pellegrini S.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] OF 289-1187CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 70:313-322 (1992)Cited in1
Identification and chromosomal mapping of new human tyrosine kinase genes.Krolewski J.J., Lee R., Eddy R., Shows T.B., Dalla-Favera R.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] OF 1007-1162, TISSUE SPECIFICITYCategoriesSequences, ExpressionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCOncogene 5:277-282 (1990)Cited in3
Putative tyrosine kinases expressed in K-562 human leukemia cells.Partanen J., Maekelae T.P., Alitalo R., Lehvaeslaiho H., Alitalo K.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] OF 1025-1082CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 87:8913-8917 (1990)Cited in5
The protein tyrosine kinase JAK1 complements defects in interferon- alpha/beta and -gamma signal transduction.Mueller M., Briscoe J., Laxton C., Guschin D., Ziemiecki A., Silvennoinen O., Harpur A.G., Barbieri G., Witthuhn B.A., Schindler C.View abstractCited forFUNCTION, PHOSPHORYLATIONCategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 366:129-135 (1993)Cited in2Mapped to19
Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta.Abramovich C., Shulman L.M., Ratovitski E., Harroch S., Tovey M., Eid P., Revel M.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCEMBO J. 13:5871-5877 (1994)Cited in3
Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.Colamonici O., Yan H., Domanski P., Handa R., Smalley D., Mullersman J., Witte M., Krishnan K., Krolewski J.View abstractCited forFUNCTION, CATALYTIC ACTIVITYCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell. Biol. 14:8133-8142 (1994)Cited in2Mapped to16
Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor.Quelle F.W., Thierfelder W., Witthuhn B.A., Tang B., Cohen S., Ihle J.N.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 270:20775-20780 (1995)Cited in3Mapped to4
Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.Bacon C.M., Petricoin E.F. III, Ortaldo J.R., Rees R.C., Larner A.C., Johnston J.A., O'Shea J.J.View abstractCited forFUNCTION, PHOSPHORYLATIONCategoriesFunction, PTM / ProcessingSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 92:7307-7311 (1995)Cited in3Mapped to4
Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase.Gauzzi M.C., Velazquez L., McKendry R., Mogensen K.E., Fellous M., Pellegrini S.View abstractCited forFUNCTION, MUTAGENESIS OF LYS-930; TYR-1054; TYR-1055; TYR-1145 AND TYR-1176, PHOSPHORYLATION AT TYR-1054 AND TYR-1055CategoriesFunction, PTM / Processing, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 271:20494-20500 (1996)Cited in1Mapped to19
Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase.Rani M.R., Leaman D.W., Han Y., Leung S., Croze E., Fish E.N., Wolfman A., Ransohoff R.M.View abstractCited forFUNCTION, CATALYTIC ACTIVITYCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 274:32507-32511 (1999)Cited in1Mapped to17
The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-alpha.Li S., Labrecque S., Gauzzi M.C., Cuddihy A.R., Wong A.H., Pellegrini S., Matlashewski G.J., Koromilas A.E.View abstractCited forINTERACTION WITH PAPILLOMAVIRUS VIRUS PROTEIN E6 (MICROBIAL INFECTION)CategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCOncogene 18:5727-5737 (1999)Cited in2Mapped to3
Urokinase stimulates human vascular smooth muscle cell migration via a phosphatidylinositol 3-kinase-Tyk2 interaction.Kusch A., Tkachuk S., Haller H., Dietz R., Gulba D.C., Lipp M., Dumler I.View abstractCited forFUNCTION IN CELL MIGRATION, INTERACTION WITH PIK3R1CategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 275:39466-39473 (2000)Cited in2
Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules.Steindler C., Li Z., Algarte M., Alcover A., Libri V., Ragimbeau J., Pellegrini S.View abstractCited forINTERACTION WITH JAKMIP1CategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 279:43168-43177 (2004)Cited in4Mapped to2
Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity.Minegishi Y., Saito M., Morio T., Watanabe K., Agematsu K., Tsuchiya S., Takada H., Hara T., Kawamura N.[...], Karasuyama H.View abstractCited forINVOLVEMENT IN IMD35CategoriesDisease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCImmunity 25:745-755 (2006)Cited in1
The Epstein-Barr virus-encoded LMP-1 oncoprotein negatively affects Tyk2 phosphorylation and interferon signaling in human B cells.Geiger T.R., Martin J.M.View abstractCited forINTERACTION WITH EPSTEIN-BARR VIRUS PROTEIN LMP1 (MICROBIAL INFECTION)CategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Virol. 80:11638-11650 (2006)Cited in2Mapped to17
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.View abstractCited forPHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-292 AND SER-884, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]TissueCervix carcinomaCategoriesPTM / Processing, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell 31:438-448 (2008)Cited in99+99+
Large-scale proteomics analysis of the human kinome.Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.View abstractCited forPHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-292 AND SER-884, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]CategoriesPTM / Processing, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell. Proteomics 8:1751-1764 (2009)Cited in99+99+
Toward a comprehensive characterization of a human cancer cell phosphoproteome.Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.View abstractCited forPHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-292 AND SER-499, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]TissueCervix carcinomaCategoriesPTM / Processing, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Proteome Res. 12:260-271 (2013)Cited in99+99+
TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity.Mori R., Wauman J., Icardi L., Van der Heyden J., De Cauwer L., Peelman F., De Bosscher K., Tavernier J.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCSci. Rep. 7:15919-15919 (2017)Cited in1Mapped to10
Epstein-Barr Virus (EBV) Tegument Protein BGLF2 Suppresses Type I Interferon Signaling To Promote EBV Reactivation.Liu X., Sadaoka T., Krogmann T., Cohen J.I.View abstractCited forINTERACTION WITH EPSTEIN-BARR VIRUS TEGUMENT PROTEIN BGLF2 (MICROBIAL INFECTION)CategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Virol. 94:0-0 (2020)Cited in3
Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.Chrencik J.E., Patny A., Leung I.K., Korniski B., Emmons T.L., Hall T., Weinberg R.A., Gormley J.A., Williams J.M.[...], Benson T.E.View abstractCited forX-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 888-1182 IN COMPLEX WITH INHIBITOR, PHOSPHORYLATION AT TYR-1054CategoriesPTM / Processing, Interaction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Mol. Biol. 400:413-433 (2010)Cited in1Mapped to10
Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.Tokarski J.S., Zupa-Fernandez A., Tredup J.A., Pike K., Chang C., Xie D., Cheng L., Pedicord D., Muckelbauer J.[...], Burke J.R.View abstractCited forX-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 575-869, FUNCTION, ACTIVITY REGULATIONCategoriesFunction, StructureSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 290:11061-11074 (2015)Cited in1Mapped to3