P29190 · PCKG_HAECO

Function

function

In parasitic nematodes PEPCK carboxylates phosphoenolpyruvate to oxaloacetate thus introducing the products of glycolysis to mitochondrial metabolism.
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site81substrate
Binding site230-232substrate
Binding site239Mn2+ (UniProtKB | ChEBI)
Binding site259Mn2+ (UniProtKB | ChEBI)
Binding site281substrate
Binding site282-287GTP (UniProtKB | ChEBI)
Active site283
Binding site306Mn2+ (UniProtKB | ChEBI)
Binding site399-401substrate
Binding site401GTP (UniProtKB | ChEBI)
Binding site432GTP (UniProtKB | ChEBI)
Binding site525-528GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEPCK

Gene names

    • Name
      PEPCK

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Strongyloidea > Trichostrongylidae > Haemonchus

Accessions

  • Primary accession
    P29190

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001036331-619Phosphoenolpyruvate carboxykinase [GTP]

Interaction

Subunit

Monomer.

Structure

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    619
  • Mass (Da)
    69,656
  • Last updated
    1992-12-01 v1
  • Checksum
    40A801A1EB647CFD
MKRLGHVPIHKGDFHLLPPKVQRFVAEKAELMRPRGIYICDGSQHEADEIIDKLIERGMLSPLKAYENNYICRTDPKDVARVESKTWMVTPDKYQTVCHTPDGIEPIMGHWMSPDSLATELDSRFPGCMAGRIMYVIPFSMGPVGGPLSKIGVQLTDSNYVVLSMRIMTRVGHEVWDALGDNDFVRCIHSVGLPRPVKQRVINHWPCNPERVLIAHRPAEREIWSFGSGYGGNSLLGKKMLALRIASNIAKDEGWMAEHMLIMGVTRPDGKEHFIAAAFPSACGKTNLAMLEPALPGWKVRCVGDDIAWMKFGEDGRLYAINPEYGFFGVAPGTSKKTNPMAVATFQKNSIFTNVGETANGEYFWEGLEDEIKDKNVDMINWLGEKWRIGDPGLCAHPNSRFAAPASQCPIIHPEWESPKGVPIDAIIFGGRRPAGVPLVFETRSWLHGIFTGACLKSEATAAAEHKGKTVMHDPMAMRPFMGYNFGHYLQHWIDLNKDGRKVPKIYHVNWFRRDANNKFLWPGYGQNIRVIDWIVRRLDGEPDIGVDTPIGIVPKKGAINASGLPDIQWDELMSVPKEYWTNDAKEIRKFLEEQVGPDLPKEIRAEMDAQEERINKQA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M76494
EMBL· GenBank· DDBJ
AAA29180.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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