P29169 · BEL1_SFV1

Function

function

Transcriptional transactivator that activates the viral internal promoter (IP), thereby enhancing its own expression. This transactivation is repressed by nuclear factor I. Also transactivates the long terminal repeat (LTR) promoter, thereby inducing structural gene expression, initiating the late phase of infection. It is therefore a key regulator of viral gene expression. It directly binds to and activates DNA target sites of viral promoters and those of distinct cellular genes. Required for viral replication (By similarity).

Features

Showing features for dna binding.

130820406080100120140160180200220240260280300
TypeIDPosition(s)Description
DNA binding94-203

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell nucleus
Molecular FunctionDNA binding
Biological Processpositive regulation of DNA-templated transcription
Biological Processviral process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein Bel-1
  • Alternative names
    • Transactivator of spumavirus (Tas)
    • Transcriptional transactivator

Gene names

    • Name
      bel1
    • Synonyms
      taf, tas

Organism names

Accessions

  • Primary accession
    P29169

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001255101-308Protein Bel-1

Interaction

Subunit

Homodimer or homomultimer. Forms complexes with the host nuclear factors NFIA, NFIB, NFIC or NFIX (By similarity).

Family & Domains

Features

Showing features for region, compositional bias, motif.

Type
IDPosition(s)Description
Region200-242Disordered
Compositional bias203-227Basic and acidic residues
Motif217-226Nuclear localization signal
Region228-304Transactivation domain

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P29169-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    Bel-1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    308
  • Mass (Da)
    35,311
  • Last updated
    1993-07-01 v2
  • Checksum
    7E280B6EFB21D992
MASWEAQEELRELLHHLPEDDPPADLTHLLELDEMEPKVLCGENPGDEKLKKQVIKTPPMHPSTVTWHFGYKQKEDQQDNIKMRDWVPDPSKMSKSTCKRLILLGLYQACKAQEIIKMDYDVHWEKSVVNEQYFEVEYNCKMCRTVLHEPMPIMYDPETELWVKPGRLRGPLGSAVYTLKKHYERCLLTLPSLKGTRLPKRRCNPSRRYETFREHPPTRKRRSKEGIPTDQQPSTSNGDPMALLSGPCGPHSIQPPSCLLQELPKPEVGSPEMAVAMSGGPFWEEVYGDSIFATPLGSSEDQLLSQFD

P29169-2

  • Name
    Bet
  • See also
    sequence in UniParc or sequence clusters in UniRef

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias203-227Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X54482
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
M74039
EMBL· GenBank· DDBJ
AAA47802.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help