P29056 · TF3B_YEAST

Function

function

General activator of RNA polymerase III transcription. Interacts with TBP. Binds to Pol III subunit C34 and to the TAU135 component of TFIIIC.

Miscellaneous

Present with 4330 molecules/cell in log phase SD medium.

Features

Showing features for binding site.

159650100150200250300350400450500550
TypeIDPosition(s)Description
Binding site4Zn2+ (UniProtKB | ChEBI)
Binding site7Zn2+ (UniProtKB | ChEBI)
Binding site25Zn2+ (UniProtKB | ChEBI)
Binding site28Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componenttranscription factor TFIIIB complex
Cellular Componenttranscription preinitiation complex
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase III core binding
Molecular FunctionRNA polymerase III general transcription initiation factor activity
Molecular FunctionRNA polymerase III type 3 promoter sequence-specific DNA binding
Molecular FunctionTBP-class protein binding
Molecular FunctionTFIIIC-class transcription factor complex binding
Biological ProcessDNA-templated transcription initiation
Biological ProcessDNA-templated transcription open complex formation
Biological Processregulation of transcription by RNA polymerase III
Biological ProcessRNA polymerase III preinitiation complex assembly
Biological Processtranscription by RNA polymerase III

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transcription factor IIIB 70 kDa subunit
  • Short names
    TFIIIB
  • Alternative names
    • B-related factor 1 (BRF-1)

Gene names

    • Name
      BRF1
    • Synonyms
      PCF4, TDS4
    • Ordered locus names
      YGR246C

Organism names

Accessions

  • Primary accession
    P29056
  • Secondary accessions
    • D6VV26

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001193461-596Transcription factor IIIB 70 kDa subunit
Modified residue381Phosphoserine
Modified residue384Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

TFIIIB comprises the TATA-binding protein (TBP), the B-related factor (BRF) and the B' component (TFC5).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P29056SPT15 P133933EBI-19142, EBI-19129
View interactors in UniProtKB
View CPX-1143 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for zinc finger, repeat, region, compositional bias.

TypeIDPosition(s)Description
Zinc finger1-33TFIIB-type
Repeat90-1661
Repeat185-2642
Region363-421Disordered
Compositional bias367-421Basic and acidic residues
Region509-534Disordered

Sequence similarities

Belongs to the TFIIB family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    596
  • Mass (Da)
    66,906
  • Last updated
    1992-12-01 v1
  • Checksum
    489207643A66B796
MPVCKNCHGTEFERDLSNANNDLVCKACGVVSEDNPIVSEVTFGETSAGAAVVQGSFIGAGQSHAAFGGSSALESREATLNNARRKLRAVSYALHIPEYITDAAFQWYKLALANNFVQGRRSQNVIASCLYVACRKEKTHHMLIDFSSRLQVSVYSIGATFLKMVKKLHITELPLADPSLFIQHFAEKLDLADKKIKVVKDAVKLAQRMSKDWMFEGRRPAGIAGACILLACRMNNLRRTHTEIVAVSHVAEETLQQRLNEFKNTKAAKLSVQKFRENDVEDGEARPPSFVKNRKKERKIKDSLDKEEMFQTSEEALNKNPILTQVLGEQELSSKEVLFYLKQFSERRARVVERIKATNGIDGENIYHEGSENETRKRKLSEVSIQNEHVEGEDKETEGTEEKVKKVKTKTSEEKKENESGHFQDAIDGYSLETDPYCPRNLHLLPTTDTYLSKVSDDPDNLEDVDDEELNAHLLNEEASKLKERIWIGLNADFLLEQESKRLKQEADIATGNTSVKKKRTRRRNNTRSDEPTKTVDAAAAIGLMSDLQDKSGLHAALKAAEESGDFTTADSVKNMLQKASFSKKINYDAIDGLFR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias367-421Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M91073
EMBL· GenBank· DDBJ
AAB04945.1
EMBL· GenBank· DDBJ
Genomic DNA
L00630
EMBL· GenBank· DDBJ
AAA35148.1
EMBL· GenBank· DDBJ
Genomic DNA
Y07703
EMBL· GenBank· DDBJ
CAA68968.1
EMBL· GenBank· DDBJ
Genomic DNA
Z73031
EMBL· GenBank· DDBJ
CAA97275.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006941
EMBL· GenBank· DDBJ
DAA08337.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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