P29052 · TF2B_DROME

Function

function

General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.

Features

Showing features for binding site.

131520406080100120140160180200220240260280300
TypeIDPosition(s)Description
Binding site14Zn2+ (UniProtKB | ChEBI)
Binding site17Zn2+ (UniProtKB | ChEBI)
Binding site33Zn2+ (UniProtKB | ChEBI)
Binding site36Zn2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Cellular Componenttranscription preinitiation complex
Molecular Functionacetyltransferase activity
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II general transcription initiation factor activity
Molecular FunctionTBP-class protein binding
Biological ProcessmRNA transcription by RNA polymerase II
Biological Processtranscription initiation at RNA polymerase II promoter
Biological Processtranscription preinitiation complex assembly
Biological Processtranscriptional start site selection at RNA polymerase II promoter

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transcription initiation factor IIB
  • Alternative names
    • General transcription factor TFIIB

Gene names

    • Name
      TfIIB
    • ORF names
      CG5193

Organism names

  • Taxonomic identifier
  • Strains
    • Canton-S
    • Oregon-R
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    P29052
  • Secondary accessions
    • Q6AWH9
    • Q9VKV7

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001192991-315Transcription initiation factor IIB

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (Tafs). Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for zinc finger, repeat.

TypeIDPosition(s)Description
Zinc finger10-41TFIIB-type
Repeat123-1991
Repeat217-2932

Sequence similarities

Belongs to the TFIIB family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    315
  • Mass (Da)
    34,369
  • Last updated
    1992-12-01 v1
  • Checksum
    AA5803F7B94BB1F4
MASTSRLDNNKVCCYAHPESPLIEDYRAGDMICSECGLVVGDRVIDVGSEWRTFSNEKSGVDPSRVGGPENPLLSGGDLSTIIGPGTGSASFDAFGAPKYQNRRTMSSSDRSLISAFKEISSMADRINLPKTIVDRANNLFKQVHDGKNLKGRSNDAKASACLYIACRQEGVPRTFKEICAVSKISKKEIGRCFKLTLKALETSVDLITTADFMCRFCANLDLPNMVQRAATHIAKKAVEMDIVPGRSPISVAAAAIYMASQASEHKRSQKEIGDIAGVADVTIRQSYKLMYPHAAKLFPEDFKFTTPIDQLPQM

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
M9PCM4M9PCM4_DROMETfIIB315

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M88164
EMBL· GenBank· DDBJ
AAA28930.1
EMBL· GenBank· DDBJ
mRNA
M91081
EMBL· GenBank· DDBJ
AAA28929.1
EMBL· GenBank· DDBJ
mRNA
U02879
EMBL· GenBank· DDBJ
AAA68626.1
EMBL· GenBank· DDBJ
Genomic DNA
U35148
EMBL· GenBank· DDBJ
AAA79093.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014134
EMBL· GenBank· DDBJ
AAF52951.1
EMBL· GenBank· DDBJ
Genomic DNA
BT011459
EMBL· GenBank· DDBJ
AAR99117.1
EMBL· GenBank· DDBJ
mRNA
BT015269
EMBL· GenBank· DDBJ
AAT94498.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp