P28795 · PEX3_YEAST
- ProteinPeroxisomal biogenesis factor 3
- GenePEX3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids441 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in peroxisome biosynthesis (PubMed:1894692).
Acts as a regulator of MSP1 by inhibiting the ability of MSP1 to unfold target proteins (PubMed:32541053).
Acts as a regulator of MSP1 by inhibiting the ability of MSP1 to unfold target proteins (PubMed:32541053).
Miscellaneous
Present with 1400 molecules/cell in log phase SD medium.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | peroxisomal membrane | |
Cellular Component | peroxisome | |
Molecular Function | protein-macromolecule adaptor activity | |
Biological Process | ER-dependent peroxisome organization | |
Biological Process | peroxisome inheritance | |
Biological Process | protein import into peroxisome membrane |
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended namePeroxisomal biogenesis factor 3
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP28795
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Peroxisome membrane ; Single-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-17 | Peroxisomal | ||||
Sequence: MAPNQRSRSLLQRHRGK | ||||||
Transmembrane | 18-39 | Helical | ||||
Sequence: VLISLTGIAALFTTGSVVVFFV | ||||||
Topological domain | 40-441 | Cytoplasmic | ||||
Sequence: KRWLYKQQLRITEQHFIKEQIKRRFEQTQEDSLYTIYELLPVWRMVLNENDLNLDSIVTQLKDQKNQLTRAKSSESRESSPLKSKAELWNELELKSLIKLVTVTYTVSSLILLTRLQLNILTRNEYLDSAIKLTMQQENCNKLQNRFYNWVTSWWSDPEDKADDAMVMAAKKSKKEGQEVYINEQAFLSLSWWILNKGWLSYNEIITNQIEIEFDGIHPRDTLTLEEFSSRLTNIFRNTNSQIFQQNNNNLTSILLPKDSSGQEFLLSQTLDADALTSFHSNTLVFNQLVNELTQCIESTATSIVLESLINESFHFIMNKVGIKTIAKKKPGQEDQQQYQMAVFAMSMKDCCQEMLQTTAGSSHSGSVNEYLATLDSVQPLDDLSASVYSNFGVSSSFSFKP |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Lack of this protein causes the peroxisomal-deficient phenotype and mislocalization in the cytosol of peroxisomal matrix proteins.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 12 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000208747 | 1-441 | Peroxisomal biogenesis factor 3 | |||
Sequence: MAPNQRSRSLLQRHRGKVLISLTGIAALFTTGSVVVFFVKRWLYKQQLRITEQHFIKEQIKRRFEQTQEDSLYTIYELLPVWRMVLNENDLNLDSIVTQLKDQKNQLTRAKSSESRESSPLKSKAELWNELELKSLIKLVTVTYTVSSLILLTRLQLNILTRNEYLDSAIKLTMQQENCNKLQNRFYNWVTSWWSDPEDKADDAMVMAAKKSKKEGQEVYINEQAFLSLSWWILNKGWLSYNEIITNQIEIEFDGIHPRDTLTLEEFSSRLTNIFRNTNSQIFQQNNNNLTSILLPKDSSGQEFLLSQTLDADALTSFHSNTLVFNQLVNELTQCIESTATSIVLESLINESFHFIMNKVGIKTIAKKKPGQEDQQQYQMAVFAMSMKDCCQEMLQTTAGSSHSGSVNEYLATLDSVQPLDDLSASVYSNFGVSSSFSFKP |
Proteomic databases
PTM databases
Expression
Induction
By oleic acid.
Interaction
Subunit
Interacts with MSP1; leading to inhibit the translocase activity of MSP1.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | P28795 | INP1 Q03694 | 6 | EBI-13164, EBI-27445 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Sequence similarities
Belongs to the peroxin-3 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length441
- Mass (Da)50,676
- Last updated1992-12-01 v1
- Checksum3CDC1D036DF0D0F9
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X58407 EMBL· GenBank· DDBJ | CAA41309.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U32517 EMBL· GenBank· DDBJ | AAB64764.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006938 EMBL· GenBank· DDBJ | DAA12171.1 EMBL· GenBank· DDBJ | Genomic DNA |