P28473 · GBRG3_RAT

  • Protein
    Gamma-aminobutyric acid receptor subunit gamma-3
  • Gene
    Gabrg3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10462548, PubMed:1311098, PubMed:1660002).
GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity).
When activated by GABA, GABAARs selectively allow the flow of chloride across the cell membrane down their electrochemical gradient (PubMed:10462548, PubMed:1311098, PubMed:1660002).

Catalytic activity

Activity regulation

Allosterically potentiated by alphaxalone. Allosterically inhibited by pregnenolone sulfate. Inhibited by zinc and lanthanum.

GO annotations

AspectTerm
Cellular Componentchloride channel complex
Cellular Componentdendrite membrane
Cellular ComponentGABA-A receptor complex
Cellular ComponentGABA-ergic synapse
Cellular Componentmicrotubule cytoskeleton
Cellular Componentneuron projection
Cellular Componentnucleolus
Cellular Componentplasma membrane
Cellular Componentpostsynapse
Cellular Componentpostsynaptic membrane
Cellular Componentsynapse
Cellular Componentsynaptic membrane
Cellular Componenttransmembrane transporter complex
Molecular Functionchloride channel activity
Molecular FunctionGABA-A receptor activity
Molecular FunctionGABA-gated chloride ion channel activity
Molecular Functiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Processchloride transmembrane transport
Biological Processgamma-aminobutyric acid signaling pathway
Biological Processinhibitory synapse assembly
Biological Processregulation of postsynaptic membrane potential
Biological Processresponse to xenobiotic stimulus
Biological Processsynaptic transmission, GABAergic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Gamma-aminobutyric acid receptor subunit gamma-3
  • Alternative names
    • GABA(A) receptor subunit gamma-3
      (GABAAR subunit gamma-3
      )

Gene names

    • Name
      Gabrg3

Organism names

  • Taxonomic identifier
  • Strain
    • ZUR-SIV
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P28473

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain18-256Extracellular
Transmembrane257-277Helical
Topological domain278-283Cytoplasmic
Transmembrane284-303Helical
Topological domain304-311Extracellular
Transmembrane312-332Helical
Topological domain333-446Cytoplasmic
Transmembrane447-467Helical

Keywords

Phenotypes & Variants

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-17
ChainPRO_000000048318-467Gamma-aminobutyric acid receptor subunit gamma-3
Glycosylation110N-linked (GlcNAc...) asparagine
Disulfide bond171↔185
Glycosylation228N-linked (GlcNAc...) asparagine

Post-translational modification

May be palmitoylated.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in brain.

Gene expression databases

Interaction

Subunit

Heteropentamer, formed by a combination of alpha (GABRA1-6), beta (GABRB1-3), gamma (GABRG1-3), delta (GABRD), epsilon (GABRE), rho (GABRR1-3), pi (GABRP) and theta (GABRQ) chains, each subunit exhibiting distinct physiological and pharmacological properties.

Protein-protein interaction databases

Structure

Family & Domains

Domain

GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    467
  • Mass (Da)
    54,293
  • Last updated
    1992-12-01 v1
  • Checksum
    14959F565649D67D
MAAKLLLLLCLFSGLHARSRRVEEDDSEDSPSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDAHACPLTFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTTLGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTIRKKKTSLLHPDSTRWIPDRISLQAPSNYSLLDMRPPPPVMITLNNSMYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRRGRIHIDVSELDSYSRVFFPTSFLLFNLVYWVGYLYL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0A0MXX6A0A0A0MXX6_RATGabrg3428
A0A8I5ZZR3A0A8I5ZZR3_RATGabrg3141

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict416in Ref. 2; CAA44930

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M81142
EMBL· GenBank· DDBJ
AAA41181.1
EMBL· GenBank· DDBJ
mRNA
X63324
EMBL· GenBank· DDBJ
CAA44930.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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