P28358 · HXD10_HUMAN

  • Protein
    Homeobox protein Hox-D10
  • Gene
    HOXD10
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Features

Showing features for dna binding.

134050100150200250300
TypeIDPosition(s)Description
DNA binding266-325Homeobox

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentcytoplasmic ribonucleoprotein granule
Cellular Componentcytosol
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componenttranscription repressor complex
Molecular Functionchromatin binding
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functionsequence-specific double-stranded DNA binding
Biological Processadult locomotory behavior
Biological Processanterior/posterior pattern specification
Biological Processembryonic limb morphogenesis
Biological Processembryonic skeletal system morphogenesis
Biological Processforelimb morphogenesis
Biological Processhindlimb morphogenesis
Biological Processnegative regulation of cell cycle
Biological Processneuromuscular process
Biological Processperipheral nervous system neuron development
Biological Processproximal/distal pattern formation
Biological Processregulation of transcription by RNA polymerase II
Biological Processsingle fertilization
Biological Processskeletal muscle tissue development
Biological Processspinal cord motor neuron cell fate specification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homeobox protein Hox-D10
  • Alternative names
    • Homeobox protein Hox-4D
    • Homeobox protein Hox-4E

Gene names

    • Name
      HOXD10
    • Synonyms
      HOX4D, HOX4E

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P28358
  • Secondary accessions
    • Q6NT10

Proteomes

Organism-specific databases

Disease & Variants

Involvement in disease

Vertical talus, congenital (CVT)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    A rare malformation characterized by vertical orientation of the talus with a rigid dorsal dislocation of the navicular, equinus deformity of the calcaneus, abduction deformity of the forefoot, and contracture of the soft tissues of the hind- and mid-foot. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity with familial occurrence.
  • See also
    MIM:192950
Natural variants in CVT
Variant IDPosition(s)ChangeDescription
VAR_022582319M>Kin CVT; also in Charcot-Marie-Tooth disease-like foot deformities; dbSNP:rs104893634

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_022582319in CVT; also in Charcot-Marie-Tooth disease-like foot deformities; dbSNP:rs104893634

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 443 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002002261-340Homeobox protein Hox-D10
Modified residue238Phosphoserine
Modified residue239Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Strongly expressed in the adult male and female urogenital tracts.

Developmental stage

Expressed in the developing limb buds.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

View interactors in UniProtKB
View CPX-6094 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region200-268Disordered

Sequence similarities

Belongs to the Abd-B homeobox family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    340
  • Mass (Da)
    38,411
  • Last updated
    2007-04-03 v2
  • Checksum
    FA6DB8C9DD97D7C9
MSFPNSSPAANTFLVDSLISACRSDSFYSSSASMYMPPPSADMGTYGMQTCGLLPSLAKREVNHQNMGMNVHPYIPQVDSWTDPNRSCRIEQPVTQQVPTCSFTTNIKEESNCCMYSDKRNKLISAEVPSYQRLVPESCPVENPEVPVPGYFRLSQTYATGKTQEYNNSPEGSSTVMLQLNPRGAAKPQLSAAQLQMEKKMNEPVSGQEPTKVSQVESPEAKGGLPEERSCLAEVSVSSPEVQEKESKEEIKSDTPTSNWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISKSVNLTDRQVKIWFQNRRMKLKKMSRENRIRELTANLTFS

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict150in Ref. 1; CAA42017

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X59373
EMBL· GenBank· DDBJ
CAA42017.1
EMBL· GenBank· DDBJ
mRNA
BC069619
EMBL· GenBank· DDBJ
AAH69619.1
EMBL· GenBank· DDBJ
mRNA
BC074760
EMBL· GenBank· DDBJ
AAH74760.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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