P28356 · HXD9_HUMAN

  • Protein
    Homeobox protein Hox-D9
  • Gene
    HOXD9
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Caution

It is uncertain whether Met-1 or Met-11 is the initiator.

Features

Showing features for dna binding.

135250100150200250300350
TypeIDPosition(s)Description
DNA binding285-344Homeobox

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular FunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding
Molecular Functionsequence-specific double-stranded DNA binding
Biological Processadult locomotory behavior
Biological Processanterior/posterior pattern specification
Biological ProcessDNA-templated transcription
Biological Processembryonic forelimb morphogenesis
Biological Processembryonic skeletal system morphogenesis
Biological Processhindlimb morphogenesis
Biological Processmammary gland development
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processperipheral nervous system neuron development
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processproximal/distal pattern formation
Biological Processregulation of transcription by RNA polymerase II
Biological Processsingle fertilization
Biological Processskeletal muscle tissue development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homeobox protein Hox-D9
  • Alternative names
    • Homeobox protein Hox-4C
    • Homeobox protein Hox-5.2

Gene names

    • Name
      HOXD9
    • Synonyms
      HOX4C

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P28356
  • Secondary accessions
    • Q86ST1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_031851269

Variants

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The viewer provides 491 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00002002201-352UniProtHomeobox protein Hox-D9
Modified residue146UniProtPhosphoserine
Modified residue (large scale data)146PRIDEPhosphoserine
Modified residue (large scale data)199PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Developmental stage

Expressed in the developing limb buds.

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region126-208Disordered
Compositional bias170-208Polar residues
Region229-276Disordered

Sequence similarities

Belongs to the Abd-B homeobox family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    352
  • Mass (Da)
    36,495
  • Last updated
    2010-04-20 v5
  • Checksum
    ECBFE68B48C0F532
MLGGSAGRLKMSSSGTLSNYYVDSLIGHEGDEVFAARFGPPGPGAQGRPAGVADGPAATAAEFASCSFAPRSAVFSASWSAVPSQPPAAAAMSGLYHPYVPPPPLAASASEPGRYVRSWMEPLPGFPGGAGGGGGGGGGGPGRGPSPGPSGPANGRHYGIKPETRAAPAPATAASTTSSSSTSLSSSSKRTECSVARESQGSSGPEFSCNSFLQEKAAAATGGTGPGAGIGAATGTGGSSEPSACSDHPIPGCSLKEEEKQHSQPQQQQLDPNNPAANWIHARSTRKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARILNLTERQVKIWFQNRRMKMKKMSKEKCPKGD

Sequence caution

The sequence AAH44855.2 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence CAA42016.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict144-156in Ref. 3; AAH44855
Compositional bias170-208Polar residues
Sequence conflict219-224in Ref. 1; CAA42016
Sequence conflict276in Ref. 1; CAA42016

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X59372
EMBL· GenBank· DDBJ
CAA42016.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AC009336
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC044855
EMBL· GenBank· DDBJ
AAH44855.2
EMBL· GenBank· DDBJ
mRNA Different initiation
X15506
EMBL· GenBank· DDBJ
CAA33528.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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