P28325 · CYTD_HUMAN
- ProteinCystatin-D
- GeneCST5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids142 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.
Temperature Dependence
Thermostable.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 32 | Reactive site | ||||
Sequence: G |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | extracellular exosome | |
Cellular Component | extracellular region | |
Cellular Component | extracellular space | |
Cellular Component | vesicle | |
Molecular Function | cysteine-type endopeptidase inhibitor activity |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameCystatin-D
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP28325
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_002208 | 46 | in 45% of the population; dbSNP:rs1799841 | |||
Sequence: C → R |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 257 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MMWPMHTPLLLLTALMVAVA | ||||||
Chain | PRO_0000006645 | 21-142 | Cystatin-D | |||
Sequence: GSASAQSRTLAGGIHATDLNDKSVQCALDFAISEYNKVINKDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFNDQPKLKEEEFCSFQINEVPWEDKISILNYKCRKV | ||||||
Disulfide bond | 95↔105 | |||||
Sequence: CTKSQPNLDNC | ||||||
Disulfide bond | 119↔139 | |||||
Sequence: CSFQINEVPWEDKISILNYKC |
Keywords
- PTM
Proteomic databases
Expression
Tissue specificity
Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in parotid gland but not in seminal vesicle, prostate, epididymis, testis, ovary, placenta, thyroid, gastric corpus, small intestine, liver, or gall bladder tissue.
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 70-74 | Secondary area of contact | ||||
Sequence: QVMAA |
Sequence similarities
Belongs to the cystatin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length142
- Mass (Da)16,080
- Last updated1992-12-01 v1
- ChecksumCEFA89BA87A0DA68
Mass Spectrometry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X59964 EMBL· GenBank· DDBJ | CAA42590.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X70377 EMBL· GenBank· DDBJ | CAA49838.1 EMBL· GenBank· DDBJ | mRNA | ||
AL591074 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC062678 EMBL· GenBank· DDBJ | AAH62678.1 EMBL· GenBank· DDBJ | mRNA | ||
BC069514 EMBL· GenBank· DDBJ | AAH69514.1 EMBL· GenBank· DDBJ | mRNA |