P28270 · DHE3_ELEEL
- ProteinGlutamate dehydrogenase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity).
Catalytic activity
- H2O + L-glutamate + NAD+ = 2-oxoglutarate + H+ + NADH + NH4+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 31 | substrate | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial matrix | |
Molecular Function | glutamate dehydrogenase (NAD+) activity | |
Molecular Function | glutamate dehydrogenase (NADP+) activity | |
Molecular Function | glutamate dehydrogenase [NAD(P)+] activity | |
Biological Process | glutamine metabolic process | |
Biological Process | tricarboxylic acid metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutamate dehydrogenase
- EC number
- Short namesGDH
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Gymnotiformes > Gymnotoidei > Gymnotidae > Electrophorus
Accessions
- Primary accessionP28270
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000182744 | 1-51 | Glutamate dehydrogenase | |||
Sequence: SEAVAEKEDDPNFFKMVEGFFDKGAAIVENKLVEDLKTRGSPEVEGNLTFT |
Interaction
Structure
Family & Domains
Sequence similarities
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Family and domain databases
Sequence
- Sequence statusFragments
- Length51
- Mass (Da)5,650
- Last updated1992-12-01 v1
- Checksum499A36DF9A05B004
Features
Showing features for non-adjacent residues, non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-adjacent residues | 43-44 | |||||
Sequence: EV | ||||||
Non-terminal residue | 51 | |||||
Sequence: T |
Keywords
- Technical term