P28221 · 5HT1D_HUMAN

  • Protein
    5-hydroxytryptamine receptor 1D
  • Gene
    HTR1D
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731).
Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731).
Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731).
HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed:33762731).
Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity (PubMed:18476671, PubMed:20945968).
May also play a role in regulating the release of other neurotransmitters (PubMed:18476671, PubMed:20945968).
May play a role in vasoconstriction (PubMed:18476671, PubMed:20945968).

Features

Showing features for binding site.

137750100150200250300350
TypeIDPosition(s)Description
Binding site118serotonin (UniProtKB | ChEBI)
Binding site122serotonin (UniProtKB | ChEBI)
Binding site321serotonin (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentdendrite
Cellular Componentplasma membrane
Cellular Componentsynapse
Molecular FunctionG protein-coupled serotonin receptor activity
Molecular Functionneurotransmitter receptor activity
Biological Processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Processadenylate cyclase-inhibiting serotonin receptor signaling pathway
Biological Processchemical synaptic transmission
Biological ProcessG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Biological Processintestine smooth muscle contraction
Biological Processregulation of behavior
Biological Processregulation of locomotion
Biological Processvasoconstriction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-hydroxytryptamine receptor 1D
  • Short names
    5-HT-1D
    ; 5-HT1D
  • Alternative names
    • Serotonin 1D alpha receptor
      (5-HT-1D-alpha
      )
    • Serotonin receptor 1D

Gene names

    • Name
      HTR1D
    • Synonyms
      HTR1DA, HTRL

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P28221

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-38Extracellular
Transmembrane39-64Helical; Name=1
Topological domain65-75Cytoplasmic
Transmembrane76-97Helical; Name=2
Topological domain98-109Extracellular
Transmembrane110-134Helical; Name=3
Topological domain135-154Cytoplasmic
Transmembrane155-176Helical; Name=4
Topological domain177-194Extracellular
Transmembrane195-218Helical; Name=5
Topological domain219-300Cytoplasmic
Transmembrane301-326Helical; Name=6
Topological domain327-335Extracellular
Transmembrane336-359Helical; Name=7
Topological domain360-377Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_011834265in dbSNP:rs6299

Variants

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The viewer provides 443 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00000689271-3775-hydroxytryptamine receptor 1D
Glycosylation5N-linked (GlcNAc...) asparagine
Glycosylation17N-linked (GlcNAc...) asparagine
Glycosylation21N-linked (GlcNAc...) asparagine
Disulfide bond111↔188

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Detected in brain neocortex and caudate nucleus (at protein level).

Gene expression databases

    • ENSG00000179546Expressed in male germ line stem cell (sensu Vertebrata) in testis and 57 other cell types or tissues

Organism-specific databases

Interaction

Subunit

Homodimer. Heterodimer with HTR1B.

Protein-protein interaction databases

Chemistry

Miscellaneous

Family & Domains

Features

Showing features for region, motif.

TypeIDPosition(s)Description
Region1-23Disordered
Motif135-137DRY motif; important for ligand-induced conformation changes
Motif352-356NPxxY motif; important for ligand-induced conformation changes and signaling

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    377
  • Mass (Da)
    41,907
  • Last updated
    1992-12-01 v1
  • Checksum
    0A4FCF81FFE2322A
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M89955
EMBL· GenBank· DDBJ
AAA35491.1
EMBL· GenBank· DDBJ
Genomic DNA
M81589
EMBL· GenBank· DDBJ
AAA60315.1
EMBL· GenBank· DDBJ
mRNA
AF498979
EMBL· GenBank· DDBJ
AAM21126.1
EMBL· GenBank· DDBJ
mRNA
BT007027
EMBL· GenBank· DDBJ
AAP35673.1
EMBL· GenBank· DDBJ
mRNA
AL049576
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC007720
EMBL· GenBank· DDBJ
AAH07720.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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