P28221 · 5HT1D_HUMAN
- Protein5-hydroxytryptamine receptor 1D
- GeneHTR1D
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids377 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731).
Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731).
Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731).
HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed:33762731).
Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity (PubMed:18476671, PubMed:20945968).
May also play a role in regulating the release of other neurotransmitters (PubMed:18476671, PubMed:20945968).
May play a role in vasoconstriction (PubMed:18476671, PubMed:20945968).
Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731).
Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731).
HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed:33762731).
Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity (PubMed:18476671, PubMed:20945968).
May also play a role in regulating the release of other neurotransmitters (PubMed:18476671, PubMed:20945968).
May play a role in vasoconstriction (PubMed:18476671, PubMed:20945968).
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | dendrite | |
Cellular Component | plasma membrane | |
Cellular Component | synapse | |
Molecular Function | G protein-coupled serotonin receptor activity | |
Molecular Function | neurotransmitter receptor activity | |
Biological Process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | |
Biological Process | adenylate cyclase-inhibiting serotonin receptor signaling pathway | |
Biological Process | chemical synaptic transmission | |
Biological Process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | |
Biological Process | intestine smooth muscle contraction | |
Biological Process | regulation of behavior | |
Biological Process | regulation of locomotion | |
Biological Process | vasoconstriction |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name5-hydroxytryptamine receptor 1D
- Short names5-HT-1D ; 5-HT1D
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionP28221
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-38 | Extracellular | ||||
Sequence: MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALK | ||||||
Transmembrane | 39-64 | Helical; Name=1 | ||||
Sequence: ISLAVVLSVITLATVLSNAFVLTTIL | ||||||
Topological domain | 65-75 | Cytoplasmic | ||||
Sequence: LTRKLHTPANY | ||||||
Transmembrane | 76-97 | Helical; Name=2 | ||||
Sequence: LIGSLATTDLLVSILVMPISIA | ||||||
Topological domain | 98-109 | Extracellular | ||||
Sequence: YTITHTWNFGQI | ||||||
Transmembrane | 110-134 | Helical; Name=3 | ||||
Sequence: LCDIWLSSDITCCTASILHLCVIAL | ||||||
Topological domain | 135-154 | Cytoplasmic | ||||
Sequence: DRYWAITDALEYSKRRTAGH | ||||||
Transmembrane | 155-176 | Helical; Name=4 | ||||
Sequence: AATMIAIVWAISICISIPPLFW | ||||||
Topological domain | 177-194 | Extracellular | ||||
Sequence: RQAKAQEEMSDCLVNTSQ | ||||||
Transmembrane | 195-218 | Helical; Name=5 | ||||
Sequence: ISYTIYSTCGAFYIPSVLLIILYG | ||||||
Topological domain | 219-300 | Cytoplasmic | ||||
Sequence: RIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKAT | ||||||
Transmembrane | 301-326 | Helical; Name=6 | ||||
Sequence: KILGIILGAFIICWLPFFVVSLVLPI | ||||||
Topological domain | 327-335 | Extracellular | ||||
Sequence: CRDSCWIHP | ||||||
Transmembrane | 336-359 | Helical; Name=7 | ||||
Sequence: ALFDFFTWLGYLNSLINPIIYTVF | ||||||
Topological domain | 360-377 | Cytoplasmic | ||||
Sequence: NEEFRQAFQKIVPFRKAS |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_011834 | 265 | in dbSNP:rs6299 | |||
Sequence: S → L |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 443 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000068927 | 1-377 | 5-hydroxytryptamine receptor 1D | |||
Sequence: MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS | ||||||
Glycosylation | 5 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 17 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 21 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 111↔188 | |||||
Sequence: CDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDC |
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for region, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-23 | Disordered | ||||
Sequence: MSPLNQSAEGLPQEASNRSLNAT | ||||||
Motif | 135-137 | DRY motif; important for ligand-induced conformation changes | ||||
Sequence: DRY | ||||||
Motif | 352-356 | NPxxY motif; important for ligand-induced conformation changes and signaling | ||||
Sequence: NPIIY |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length377
- Mass (Da)41,907
- Last updated1992-12-01 v1
- Checksum0A4FCF81FFE2322A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M89955 EMBL· GenBank· DDBJ | AAA35491.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M81589 EMBL· GenBank· DDBJ | AAA60315.1 EMBL· GenBank· DDBJ | mRNA | ||
AF498979 EMBL· GenBank· DDBJ | AAM21126.1 EMBL· GenBank· DDBJ | mRNA | ||
BT007027 EMBL· GenBank· DDBJ | AAP35673.1 EMBL· GenBank· DDBJ | mRNA | ||
AL049576 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC007720 EMBL· GenBank· DDBJ | AAH07720.1 EMBL· GenBank· DDBJ | mRNA |