P28183 · SAHH_RHOCB
- ProteinAdenosylhomocysteinase
- GeneahcY
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids463 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
Catalytic activity
- H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine
Cofactor
Note: Binds 1 NAD+ per subunit.
Pathway
Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 54 | substrate | ||||
Sequence: T | ||||||
Binding site | 128 | substrate | ||||
Sequence: D | ||||||
Binding site | 189 | substrate | ||||
Sequence: E | ||||||
Binding site | 190-192 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: TTT | ||||||
Binding site | 219 | substrate | ||||
Sequence: K | ||||||
Binding site | 223 | substrate | ||||
Sequence: D | ||||||
Binding site | 224 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 253-258 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GYGDVG | ||||||
Binding site | 276 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 311 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 332-334 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: IGH | ||||||
Binding site | 377 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | adenosylhomocysteinase activity | |
Biological Process | L-homocysteine biosynthetic process | |
Biological Process | one-carbon metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosylhomocysteinase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Paracoccaceae > Rhodobacter
Accessions
- Primary accessionP28183
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000116983 | 1-463 | Adenosylhomocysteinase | |||
Sequence: MADYIVKDIKLAEFGRKELDIAETEMPGLMACREEFGPSQPLKGARIAGSLHMTIQTAVLIETLKALGADVRWASCNIFSTQDHAAAAIAAGGTPVFAVKGETLEEYWAYTDKIFQFPEGTCNMILDDGGDATLYILLGARVEAGETDLIATPTSEEEVCLFNQIKKRMVESPGWFTQQRAAIKGVSEETTTGVHRLYDLHKKGLLPFPAINVNDSVTKSKFDNKYGCKESLVDGIRRATDVMMAGKVAVVCGYGDVGKGSAASLRGAGARVKVTEVDPICALQAAMDGFEVVVLEDVVADADIFITTTGNKDVIRIEHMREMKDMAIVGNIGHFDNEIQVAALKNHKWTNIKDQVDMIEMPSGARIILLSEGRLLNLGNATGHPSFVMSASFTNQVLAQIELWTKGAEYQPGVYILPKSLDEKVARLHLKKIGVKLTTLRPDQAEYIGVTVEGPFKSDHYRY |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length463
- Mass (Da)50,594
- Last updated2011-06-28 v2
- Checksum44EBA9744B2FCA24
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 157 | in Ref. 1; AAA26094 | ||||
Sequence: E → D |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M80630 EMBL· GenBank· DDBJ | AAA26094.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP001312 EMBL· GenBank· DDBJ | ADE83814.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L23836 EMBL· GenBank· DDBJ | AAA53540.1 EMBL· GenBank· DDBJ | Genomic DNA |