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P28094 · WNT1_STRPU

Function

function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functioncytokine activity
Molecular Functionfrizzled binding
Biological Processcanonical Wnt signaling pathway
Biological Processcell fate commitment
Biological Processneuron differentiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein Wnt-1

Gene names

    • Name
      WNT-1

Organism names

Accessions

  • Primary accession
    P28094

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain, disulfide bond, lipidation, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00002006071-223Protein Wnt-1
Disulfide bond7↔24
Disulfide bond72↔86
Disulfide bond74↔81
Lipidation78O-palmitoleoyl serine; by PORCN
Disulfide bond152↔183
Disulfide bond168↔178
Glycosylation169N-linked (GlcNAc...) asparagine
Disulfide bond182↔222
Disulfide bond198↔213
Disulfide bond200↔210
Disulfide bond205↔206

Post-translational modification

Palmitoleoylation is required for efficient binding to frizzled receptors. Palmitoleoylation is necessary for proper trafficking to cell surface (By similarity).
Depalmitoleoylated by NOTUM, leading to inhibit Wnt signaling pathway (By similarity).

Keywords

PTM databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region110-135Disordered

Sequence similarities

Belongs to the Wnt family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    223
  • Mass (Da)
    25,236
  • Last updated
    1997-11-01 v2
  • MD5 Checksum
    0E82EFFF5F7B0E5217FF059B822E33FE
TIESCTCDYKFRGDSGNDWEWGGCSDNADFGHRFGKKFVDSGEKGRDLRHAMNLHNNEAGRKTVSSEMRRECKCHGMSGSCTIETCWMRLPTFRTVGELIKERFDGASRVTMRNDGSPSDRETESSFVPYNPSHKQPASRDLVYFENSPDFCERNDKFGTPGTRGRECNATSLGVDGCDLMCCSRGSTTTEIKVKERCSCTFHWCCKVKCEECTSFRTVHRCL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U88625
EMBL· GenBank· DDBJ
AAC69241.1
EMBL· GenBank· DDBJ
mRNA
M91302
EMBL· GenBank· DDBJ
AAA30083.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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