P27989 · DCMB_MOOTH

Function

function

The beta subunit (this protein) generates CO from CO2, while the alpha subunit combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the alpha subunit by a corrinoid iron-sulfur protein.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
[Ni-Fe-S] cluster (UniProtKB | Rhea| CHEBI:60400 )
Note: Binds 1 [Ni-Fe-S] cluster per subunit.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )
Note: Binds 2 [4Fe-4S] clusters per homodimer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site59[4Fe-4S] cluster 1 (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site67[4Fe-4S] cluster 1 (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site68[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site71[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site76[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site90[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site283[Ni-4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site317[Ni-4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site355[Ni-4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site470[Ni-4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site500[Ni-4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site550[Ni-4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionanaerobic carbon-monoxide dehydrogenase activity
Molecular Functionhydroxylamine reductase activity
Molecular Functionnickel cation binding
Molecular Functionperoxidase activity
Biological Processcarbon fixation
Biological Processgeneration of precursor metabolites and energy
Biological Processresponse to hydrogen peroxide

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit beta
  • EC number
  • Short names
    CODH subunit; CODH/ACS; Carbon monoxide dehydrogenase subunit

Organism names

Accessions

  • Primary accession
    P27989

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000798081-674Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit beta

Interaction

Subunit

Tetramer of two alpha and two beta chains.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-25Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    674
  • Mass (Da)
    72,924
  • Last updated
    1992-08-01 v1
  • Checksum
    54BA3D816C25F9FC
MPRFRDLSHNCRPSEAPRVMEPKNRDRTVDPAVLEMLVKSKDDKVITAFDRFVAQQPQCKIGYEGICCRFCMAGPCRIKATDGPGSRGICGASAWTIVARNVGLMILTGAAAHCEHGNHIAHALVEMAEGKAPDYSVKDEAKLKEVCRRVGIEVEGKSVLELAQEVGEKALEDFRRLKGEGEATWLMTTINEGRKEKFRTHNVVPFGIHASISELVNQAHMGMDNDPVNLVFSAIRVALADYTGEHIATDFSDILFGTPQPVVSEANMGVLDPDQVNFVLHGHNPLLSEIIVQAAREMEGEAKAAGAKGINLVGICCTGNEVLMRQGIPLVTSFASQELAICTGAIDAMCVDVQCIMPSISAVAECYHTRIITTADNAKIPGAYHIDYQTATAIESAKTAIRMAIEAFKERKESNRPVYIPQIKNRVVAGWSLEALTKLLATQNAQNPIRVLNQAILDGELAGVALICGCNNLKGFQDNSHLTVMKELLKNNVFVVATGCSAQAAGKLGLLDPANVETYCGDGLKGFLKRLGEGANIEIGLPPVFHMGSCVDNSRAVDLLMAMANDLGVDTPKVPFVASAPEAMSGKAAAIGTWWVSLGVPTHVGTMPPVEGSDLIYSILTQIASDVYGGYFIFEMDPQVAARKILDALEYRTWKLGVHKEVAERYETKLCQGY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M62727
EMBL· GenBank· DDBJ
AAA23228.1
EMBL· GenBank· DDBJ
Genomic DNA

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