P27889 · HNF1B_MOUSE

  • Protein
    Hepatocyte nuclear factor 1-beta
  • Gene
    Hnf1b
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity).
Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity).
Transcriptional activity is increased by coactivator PCBD1 (By similarity).

Features

Showing features for dna binding.

155850100150200250300350400450500550
TypeIDPosition(s)Description
DNA binding231-311Homeobox; HNF1-type

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componenttranscription regulator complex
Molecular Functioncis-regulatory region sequence-specific DNA binding
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionidentical protein binding
Molecular Functionprotein homodimerization activity
Molecular Functionprotein-containing complex binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functionsequence-specific DNA binding
Molecular Functiontranscription cis-regulatory region binding
Biological Processanterior/posterior pattern specification
Biological Processapoptotic process
Biological Processbranching morphogenesis of an epithelial tube
Biological Processcircadian regulation of gene expression
Biological Processembryonic digestive tract morphogenesis
Biological Processembryonic morphogenesis
Biological Processendocrine pancreas development
Biological Processendoderm development
Biological Processendoderm formation
Biological Processendodermal cell fate specification
Biological Processepithelial cell proliferation
Biological Processepithelium development
Biological Processgenitalia development
Biological Processhepatoblast differentiation
Biological Processhindbrain development
Biological Processinner cell mass cell differentiation
Biological Processinsulin secretion
Biological Processkidney development
Biological Processkidney morphogenesis
Biological Processliver development
Biological Processmesenchymal cell apoptotic process involved in metanephros development
Biological Processmesonephric duct development
Biological Processmesonephric duct formation
Biological Processmesonephric tubule development
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis
Biological Processnegative regulation of mesenchymal cell apoptotic process involved in metanephros development
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processnephric duct development
Biological Processnephric duct formation
Biological ProcessNotch signaling pathway
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of transcription initiation by RNA polymerase II
Biological Processpronephric nephron tubule development
Biological Processprotein-DNA complex assembly
Biological Processregulation of branch elongation involved in ureteric bud branching
Biological Processregulation of pronephros size
Biological Processregulation of transcription by RNA polymerase II
Biological Processregulation of Wnt signaling pathway
Biological Processresponse to glucose
Biological Processureteric bud elongation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hepatocyte nuclear factor 1-beta
  • Short names
    HNF-1-beta; HNF-1B
  • Alternative names
    • Homeoprotein LFB3
    • Transcription factor 2 (TCF-2)

Gene names

    • Name
      Hnf1b
    • Synonyms
      Hnf-1b, Tcf2

Organism names

  • Taxonomic identifier
  • Strains
    • C3H/HeJ
    • NSY
    • NOD
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P27889
  • Secondary accessions
    • Q5NC37
    • Q8R162
    • Q9CS26
    • Q9R1W1
    • Q9R1W2

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant222in strain: NSY

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 23 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000491221-558Hepatocyte nuclear factor 1-beta
Modified residue49Phosphoserine
Modified residue52Phosphoserine
Modified residue75Phosphoserine
Modified residue80Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Binds DNA as a dimer. Can form homodimer or heterodimer with HNF1-alpha (By similarity).
Interacts (via HNF-p1 domain) with PCBD1; the interaction increases its transactivation activity (By similarity).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-31Dimerization
Domain1-32HNF-p1
Region66-85Disordered
Domain93-188POU-specific atypical
Region323-348Disordered

Sequence similarities

Belongs to the HNF1 homeobox family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

P27889-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    558
  • Mass (Da)
    61,588
  • Last updated
    2003-04-04 v2
  • Checksum
    D4F2BC92B64374A6
MVSKLTSLQQELLSALLSSGVTKEVLIQALEELLPSPNFGVKLETLPLSPGSGADLDTKPVFHTLTNGHAKGRLSGDEGSEDGDDYDTPPILKELQALNTEEAAEQRAEVDRMLSEDPWRAAKMIKGYMQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREILRQFNQTVQSSGNMTDKSSQDQLLFLFPEFSQQNQGPGQSEDTCSEPTNKKMRRNRFKWGPASQQILYQAYDRQKNPSKEEREALVEECNRAECLQRGVSPSKAHGLGSNLVTEVRVYNWFANRRKEEAFRQKLAMDAYSSNQTHNLNPLLTHGSPHHQPSSSPPNKMSGVRYNQPGNNEVTSSSTISHHGNSAMVTSQSVLQQVSPASLDPGHSLLSPDSKMQITVSGGGLPPVSTLTNIHSLSHHNPQQSQNLIMTPLSGVMAIAQSLNTSQAQGVPVINSVASSLAALQPVQFSQQLHSPHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTSRFPSAMVVTDTSSINTLTSMSSSKQCPLQAW

P27889-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P27889-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

P27889-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0A0MQH4A0A0A0MQH4_MOUSEHnf1b56
F6XBL0F6XBL0_MOUSEHnf1b199

Sequence caution

The sequence BAB31632.2 differs from that shown. Reason: Erroneous initiation

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0070991-123in isoform 3 and isoform 4
Sequence conflict67in Ref. 4; BAB31632
Alternative sequenceVSP_007100183-208in isoform 2 and isoform 4
Sequence conflict423-429in Ref. 1; CAA39358
Sequence conflict520-521in Ref. 1; CAA39358

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X55842
EMBL· GenBank· DDBJ
CAA39358.1
EMBL· GenBank· DDBJ
mRNA
AB008174
EMBL· GenBank· DDBJ
BAA77718.1
EMBL· GenBank· DDBJ
mRNA
AB008175
EMBL· GenBank· DDBJ
BAA77719.1
EMBL· GenBank· DDBJ
mRNA
AB008176
EMBL· GenBank· DDBJ
BAA77720.1
EMBL· GenBank· DDBJ
mRNA
AB008177
EMBL· GenBank· DDBJ
BAA77721.1
EMBL· GenBank· DDBJ
mRNA
AB052659
EMBL· GenBank· DDBJ
BAB60814.1
EMBL· GenBank· DDBJ
mRNA
AK004837
EMBL· GenBank· DDBJ
BAB23604.1
EMBL· GenBank· DDBJ
mRNA
AK019258
EMBL· GenBank· DDBJ
BAB31632.2
EMBL· GenBank· DDBJ
mRNA Different initiation
AL669868
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC025189
EMBL· GenBank· DDBJ
AAH25189.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp