P27784 · CCL6_MOUSE

  • Protein
    C-C motif chemokine 6
  • Gene
    Ccl6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Chemotactic factor that attracts mostly macrophage, but it can also attract B cells, CD4+ lymphocytes and eosinophils.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular FunctionCCR chemokine receptor binding
Molecular Functionchemokine activity
Biological Processantimicrobial humoral immune response mediated by antimicrobial peptide
Biological Processcell chemotaxis
Biological Processchemokine-mediated signaling pathway
Biological Processeosinophil chemotaxis
Biological Processinflammatory response
Biological Processpositive regulation of cell migration

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    C-C motif chemokine 6
  • Alternative names
    • Protein C10
    • Small-inducible cytokine A6
  • Cleaved into 2 chains

Gene names

    • Name
      Ccl6
    • Synonyms
      C10
      , Scya6

Organism names

  • Taxonomic identifier
  • Strains
    • CBA/J
    • B10.S/J
    • BALB/cJ
    • DBA/2J
    • NOD/LtJ
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P27784
  • Secondary accessions
    • Q3U3W3
    • Q5QNW1
    • Q99M24
    • Q9D830

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_000000518222-116C-C motif chemokine 6
ChainPRO_000004184443-116CCL6(22-95)
ChainPRO_000004184544-116CCL6(23-95)
Disulfide bond50↔73
Disulfide bond51↔89
Disulfide bond60↔100

Post-translational modification

The N-terminal is proteolytically cleaved by proteases associated with inflammatory responses. The processed forms CL6(22-95) and CCL6(23-95) show increase in CCR1-mediated signaling and chemotaxis assays in vitro.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF.

Induction

Associated with stimuli that promote myeloid differentiation.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    116
  • Mass (Da)
    12,984
  • Last updated
    1992-08-01 v1
  • Checksum
    2B483B5DE8417082
MRNSKTAISFFILVAVLGSQAGLIQEMEKEDRRYNPPIIHQGFQDTSSDCCFSYATQIPCKRFIYYFPTSGGCIKPGIIFISRRGTQVCADPSDRRVQRCLSTLKQGPRSGNKVIA

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict43in Ref. 8; AAH02073
Sequence conflict93in Ref. 6; BAB25734
Sequence conflict111in Ref. 8; AAH02073

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M58004
EMBL· GenBank· DDBJ
AAA37329.1
EMBL· GenBank· DDBJ
mRNA
AF128188
EMBL· GenBank· DDBJ
AAF22529.1
EMBL· GenBank· DDBJ
mRNA
AF128189
EMBL· GenBank· DDBJ
AAF22530.1
EMBL· GenBank· DDBJ
mRNA
AF128190
EMBL· GenBank· DDBJ
AAF22531.1
EMBL· GenBank· DDBJ
mRNA
AF128191
EMBL· GenBank· DDBJ
AAF22532.1
EMBL· GenBank· DDBJ
mRNA
AF128192
EMBL· GenBank· DDBJ
AAF22533.1
EMBL· GenBank· DDBJ
mRNA
AB051897
EMBL· GenBank· DDBJ
BAB18729.1
EMBL· GenBank· DDBJ
Genomic DNA
AK002697
EMBL· GenBank· DDBJ
BAB22291.1
EMBL· GenBank· DDBJ
mRNA
AK008547
EMBL· GenBank· DDBJ
BAB25734.1
EMBL· GenBank· DDBJ
mRNA
AK150336
EMBL· GenBank· DDBJ
BAE29478.1
EMBL· GenBank· DDBJ
mRNA
AK154553
EMBL· GenBank· DDBJ
BAE32672.1
EMBL· GenBank· DDBJ
mRNA
AL596122
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC002073
EMBL· GenBank· DDBJ
AAH02073.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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