P27784 · CCL6_MOUSE
- ProteinC-C motif chemokine 6
- GeneCcl6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids116 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Chemotactic factor that attracts mostly macrophage, but it can also attract B cells, CD4+ lymphocytes and eosinophils.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Molecular Function | CCR chemokine receptor binding | |
Molecular Function | chemokine activity | |
Biological Process | antimicrobial humoral immune response mediated by antimicrobial peptide | |
Biological Process | cell chemotaxis | |
Biological Process | chemokine-mediated signaling pathway | |
Biological Process | eosinophil chemotaxis | |
Biological Process | inflammatory response | |
Biological Process | positive regulation of cell migration |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameC-C motif chemokine 6
- Alternative names
- Cleaved into 2 chains
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP27784
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MRNSKTAISFFILVAVLGSQA | ||||||
Chain | PRO_0000005182 | 22-116 | C-C motif chemokine 6 | |||
Sequence: GLIQEMEKEDRRYNPPIIHQGFQDTSSDCCFSYATQIPCKRFIYYFPTSGGCIKPGIIFISRRGTQVCADPSDRRVQRCLSTLKQGPRSGNKVIA | ||||||
Chain | PRO_0000041844 | 43-116 | CCL6(22-95) | |||
Sequence: FQDTSSDCCFSYATQIPCKRFIYYFPTSGGCIKPGIIFISRRGTQVCADPSDRRVQRCLSTLKQGPRSGNKVIA | ||||||
Chain | PRO_0000041845 | 44-116 | CCL6(23-95) | |||
Sequence: QDTSSDCCFSYATQIPCKRFIYYFPTSGGCIKPGIIFISRRGTQVCADPSDRRVQRCLSTLKQGPRSGNKVIA | ||||||
Disulfide bond | 50↔73 | |||||
Sequence: CCFSYATQIPCKRFIYYFPTSGGC | ||||||
Disulfide bond | 51↔89 | |||||
Sequence: CFSYATQIPCKRFIYYFPTSGGCIKPGIIFISRRGTQVC | ||||||
Disulfide bond | 60↔100 | |||||
Sequence: CKRFIYYFPTSGGCIKPGIIFISRRGTQVCADPSDRRVQRC |
Post-translational modification
The N-terminal is proteolytically cleaved by proteases associated with inflammatory responses. The processed forms CL6(22-95) and CCL6(23-95) show increase in CCR1-mediated signaling and chemotaxis assays in vitro.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF.
Induction
Associated with stimuli that promote myeloid differentiation.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length116
- Mass (Da)12,984
- Last updated1992-08-01 v1
- Checksum2B483B5DE8417082
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 43 | in Ref. 8; AAH02073 | ||||
Sequence: F → V | ||||||
Sequence conflict | 93 | in Ref. 6; BAB25734 | ||||
Sequence: S → R | ||||||
Sequence conflict | 111 | in Ref. 8; AAH02073 | ||||
Sequence: G → R |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M58004 EMBL· GenBank· DDBJ | AAA37329.1 EMBL· GenBank· DDBJ | mRNA | ||
AF128188 EMBL· GenBank· DDBJ | AAF22529.1 EMBL· GenBank· DDBJ | mRNA | ||
AF128189 EMBL· GenBank· DDBJ | AAF22530.1 EMBL· GenBank· DDBJ | mRNA | ||
AF128190 EMBL· GenBank· DDBJ | AAF22531.1 EMBL· GenBank· DDBJ | mRNA | ||
AF128191 EMBL· GenBank· DDBJ | AAF22532.1 EMBL· GenBank· DDBJ | mRNA | ||
AF128192 EMBL· GenBank· DDBJ | AAF22533.1 EMBL· GenBank· DDBJ | mRNA | ||
AB051897 EMBL· GenBank· DDBJ | BAB18729.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK002697 EMBL· GenBank· DDBJ | BAB22291.1 EMBL· GenBank· DDBJ | mRNA | ||
AK008547 EMBL· GenBank· DDBJ | BAB25734.1 EMBL· GenBank· DDBJ | mRNA | ||
AK150336 EMBL· GenBank· DDBJ | BAE29478.1 EMBL· GenBank· DDBJ | mRNA | ||
AK154553 EMBL· GenBank· DDBJ | BAE32672.1 EMBL· GenBank· DDBJ | mRNA | ||
AL596122 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC002073 EMBL· GenBank· DDBJ | AAH02073.1 EMBL· GenBank· DDBJ | mRNA |