P27743 · ACVS_AMYLA

Function

function

Each of the constituent amino acids of the tripeptide acv are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates.

Catalytic activity

Cofactor

pantetheine 4'-phosphate (UniProtKB | Rhea| CHEBI:47942 )
Note: Binds 3 phosphopantetheines covalently.

Pathway

Antibiotic biosynthesis; penicillin G biosynthesis; penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine: step 1/3.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site3502For thioesterase activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionN-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity
Molecular Functionphosphopantetheine binding
Biological Processamino acid activation for nonribosomal peptide biosynthetic process
Biological Processantibiotic biosynthetic process
Biological Processlipid biosynthetic process
Biological Processsecondary metabolite biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
  • EC number
  • Alternative names
    • Delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase (ACV synthetase; ACVS)

Gene names

    • Name
      pcbAB

Organism names

Accessions

  • Primary accession
    P27743

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001930591-3649N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
Modified residue820O-(pantetheine 4'-phosphoryl)serine
Modified residue1896O-(pantetheine 4'-phosphoryl)serine
Modified residue2944O-(pantetheine 4'-phosphoryl)serine

Keywords

Structure

3D structure databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region401-861Domain 1 (adipate-activating)
Domain783-860Carrier 1
Region1014-1937Domain 2 (cysteine-activating)
Domain1859-1936Carrier 2
Region2079-2985Domain 3 (valine-activating)
Domain2909-2984Carrier 3

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,649
  • Mass (Da)
    404,088
  • Last updated
    1992-08-01 v1
  • Checksum
    6FD095704F858E6B
MTSARHLKSAADWCARIDAIAGQRCDLEMLLKDEWRHRVAVRDSDTAVRATQEKELTISGQDYTALKQALGAMPLEAFALATLHSVLHAYGHGHQTVVAFLRDGKVLPVVVDHLEQAGLTCAEAAEQLEDAVAREDMYLPPEELLQRGLFDALLVLADGHLGFTELPPAPLVTIVRDDPAAGCLHWRIAYAGEFFEDKIIAGVLDVAREVLGQFIGRPEQLVADIDLVSAEQELQLHQWNGTDGEFDEDKRLNELFEDVVRRAPDREAVVCGDVRLTYREVNERANQFAHWLIQGPVRVRPGALIGLYLDKSDLGVVATFGIWKSGAAYVPIDPAYPAERIRFLVGDTGLSGIVTNRRHAERLREVLGDEHASVHVIEVEAVVAGPHPEQARENPGLALSSRDRAYVTYTSGTTGVPKGVPKYHYSVVNSITDLSERYDMRRPGTERVALFASYVFEPHLRQTLIALINEQTLVIVPDDVRLDPDLFPEYIERHGVTYLNATGSVLQHFDLRRCASLKRLLLVGEELTASGLRQLREKFAGRVVNEYAFTEAAFVTAVKEFGPGVTERRDRSIGRPLRNVKWYVLSQGLKQLPIGAIGELYIGGCGVAPGYLNRDDLTAERFTANPFQTEEEKARGRNGRLYRTGDLARVLLNGEVEFMGRADFQLKLNGVRVEPGEIEAQATEFPGVKKCVVVAKENATGDRHLVGYYLVEDGAEVAEADLIAFLEQRLIRIMVPARMVRLTSIPVNVNGKVDWRALPDVSLHPAPANAMNGALLAIDGSNAPLLAITEQLRAIWSEVLGVPQNRIGERDDFFRLGGQSISCILLIARVRQRLSLSLGVEDVFALRTLDALAGHLESQGHAEPEVVAEEVTTGSEPVRVLANGLQQGLLYHHLKTAGGDDAYVVQSVHRYHAPIRPELMKDAWQAARQTYPALRLRFDWAEEPVQIVDNDDKPFDWRFVDLSATADDAEQEARVRELQERDRTEPYDLAGGRLFRVYLIKQREDLFSLIFSCHHIILDGWSLPVLHDEVHRNYLALRAGQPIESDVDNAYVAAQRYWEAHRNDHAAYWVEQLGRIDERGDFAGLLNEKSRYRVSLGDYDHVQRHRTRKLYLGADLTGALKAGCAADQVTLHSVLQFVWHKVLHAIGGGNTTVVGTIVSGRNLPVDGIENSAGLFINTLPLIVDHDQQAGQNVAEAVRDIQAAVNTMNSKSIVELGRLQSGEMKRRLFDTLLVLENYPRLLDEEEELAHQEALRFEKAYDADKVDYPIAVVAREEGDELTVTLWYAGELFDEDTIDTLLDVARTLFRQVTEDIARPVRELDLISPSMRARFDSWNETAEEFPADKTLHAVFEEMAERWPDEIAVVYRENRLTYRELNERANRLAHYLRSVVELRPDDLVALVLDKSELMITAIIAAWKTGAAYVPIDSGYPDDRISFMLSDTAARVVVTNEIHSDRLRSLAETGTPVLEIELLHLDDQPAVNPVTETTSTDLAYAIYTSGTTGKPKAVLVEHRGVVNLQVSLAKLFGLDKAHRDEALLSFSNYIFDHFVEQMTDALLNGQKLVVLDDSMRTDPGRLCRYMNDEQVTYLSGTPSVLSLYDYSSATSLTRIDAIGEDFTEPVFAKIRGTFPGLIINGYGPTEISITSHKRPYPPDVHRVNKSIGFPVANTKCHVLNKAMKPVPVGGIGELYIGGIGVTRGYLNREDLTADRFVENPFQTAEERRLGENGRLYKTGDLVRWLPNGEVEYLGRTDLQVKIRGQRVELGEVEAALSSYPGVVRSLVVAREHAVGQKYLVGFYVGEQEFDEQDLKQWMRKKLPESVVPARVLRITDIPVTPSGKLDARRLPETDFGAGEGAEYVAPVSEFELKLCGIWAQVLEIAPDRIGVHDDFFALGGDSIRAMALAQAITTGFGQGLGVATVLQHTTLAAQAEHIQAAALEHTAWTPPPTAVEHPPVSLAQERLLFIDDFEGGTAAYNIPFVLRLPAHTRAALPGALGTLVRRHPALRTLLKTDDQGVRRQYPIPADDVRLEVPSTTVDSRAELDEVLTERAGYVFRLHEELPIRAEAFDHGDEIYLSVVVHHSCFDGWSWDIFRRELAALLDGVPEADLGALRGTYGEFAVWQRQYLTGKRLAALTEFWTGALGGFETIALPLDHPRPPRFDYRGRELEFELDERTTEALRELARTARVSLYSVLLGAWCLMLNMYTGQHDLVVGTPSANRGRPEFDRAVGFFANLLALRVRVDPAATLPAYVRSVGEAVVAAQVHGELPFEQLVKELKVEKDPSRHPILQLNFTLQNVSDHTSALTGYQPDSGGWTTTKFDLSATMTETATGLAGNLTYAASLFDDTSASGFIATFKHVLAEFASAAAQTPIAQLTALDEPGQAALPDATRRARRPGGPGRCTRLFEEVAATWPDRVAVVHGDVRLTYRELNERANRLAHHLRSVAEPRADELIALVLDKSELTLVAILAVWKAGAAYMPIDPSYPDDRIAFMLSDTGAKLVLAGEAHGSRVRGLTSGDVLDLEQLDLTGEPAENPVTETTSTELAYAIYTSGTTGKPKAVLVSHGSVDSFRAQLSGRYFGSPDESAEAVLFLANYVFDFSVEQLALSVLGGHKLLVPPPSAADDPAFYELANREGLSYLSGTPTQVERFDLARLSHLRCVLVAGEAFQPQHFEKMRGEFAGPILNAYGTTETTVYNTVHRFEPGDAYRNTLGAPLGNTRLYVLGDGMKLLPTGAVGELYLAGDCVTEGYLHRPELTRERFLPNPFAAESGRFPMIYRTGDVVRRGPDGELQYLGRNDAQVKINGLRIEPGEVEAALAGCSGVRQCAVVAGADPQAPERKRLVGYYLPEPGAAVDEADLFAALRAQLMPSMVPSLLVRLDRPLPMTITGKLDVDALPSADFSPKRAAYAAPRDRVEARLCHLWSAQLPGGTVGIDDDFFRCGGDSISALHLASQVQREIERKVSVKYLFDHPTVRSFVDNVLSGLAESSGDDEPEQGRLTGECPMLPIQEWFFAKPLADRHRWNHNFAIRTPPLDPGELRTALDRLVEHHDAFRLRFPESGGEVYAEDAAPITLHELDVRGLADADLRQRLVDWQRTFDLANGPTACAAYLHGFDDGTARVWFALHHLVVDTVSWHILAQDLEILYNGGDLGAKTGSYRQWAQAVRDYTPAEGEREFWAETTRDMESAELLAQTEGTTRRREEFALTAPDTRTLLAESPWAYDTEVNDLLLTATGFALRSITRQATNHLTVEGHGRELFEGAPDVRDTVGWFTTMHPFAVEVDPGDLGRSVLATRANRRRVPHHGIGYGALFGGEAPLPAVSFNYLGRLGEGDGQPTEAWQLDPALSGSHTVDGNRLANRSSIDVTMSCTGGRLVAVVDSLLGEAATRLFASELKVWLERLVSHTATVARNEPAREATTELFDPYILVNEDAERTLFVLPPGEGGAESYLSNLARQLPDLRLVLFNNVHLHTPMGSFEELGRYYVEHIRRLQPSGPYHLLGWSFGGVLSLEISRQLARAGERIDDLLLIDPYFGMRQASANIGLPGVEDILDPINYHYRPDEADLARLAGRLGNLVLFKAGEPNDVVNGPHQPRLFEYYHGTRFNHLDLLLPAAAIEVCDLAGETHHSWVRNEKLVRLMCERISTSLGSD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X57310
EMBL· GenBank· DDBJ
CAA40561.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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