P27574 · PYP1_SCHPO
- ProteinTyrosine-protein phosphatase 1
- Genepyp1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids550 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2.
Catalytic activity
- O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 470 | Phosphocysteine intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Cellular Component | protein aggregate center | |
Molecular Function | MAP kinase tyrosine phosphatase activity | |
Molecular Function | protein tyrosine phosphatase activity | |
Biological Process | cell division | |
Biological Process | negative regulation of p38MAPK cascade | |
Biological Process | protein dephosphorylation | |
Biological Process | regulation of p38MAPK cascade |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein phosphatase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Taphrinomycotina > Schizosaccharomycetes > Schizosaccharomycetales > Schizosaccharomycetaceae > Schizosaccharomyces
Accessions
- Primary accessionP27574
Proteomes
Organism-specific databases
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 260-539 | Tyrosine-protein phosphatase | |||
Sequence similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length550
- Mass (Da)61,588
- Last updated1992-08-01 v1
- MD5 Checksum509EB167E4379DEBE193F8D2B4E3F9C3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M63257 EMBL· GenBank· DDBJ | AAA35328.1 EMBL· GenBank· DDBJ | mRNA | ||
CU329670 EMBL· GenBank· DDBJ | CAA97367.1 EMBL· GenBank· DDBJ | Genomic DNA |