P27480 · LOXA_PHAVU
- ProteinLinoleate 9S-lipoxygenase 1
- GeneLOXA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids862 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. It catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure.
Catalytic activity
- (9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate
Cofactor
Note: Binds 1 Fe cation per subunit. Iron is tightly bound.
Pathway
Lipid metabolism; oxylipin biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 522 | Fe cation (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 527 | Fe cation (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 713 | Fe cation (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 717 | Fe cation (UniProtKB | ChEBI); catalytic | ||||
Sequence: N | ||||||
Binding site | 862 | Fe cation (UniProtKB | ChEBI); catalytic | ||||
Sequence: I |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | linoleate 13S-lipoxygenase activity | |
Molecular Function | linoleate 9S-lipoxygenase activity | |
Molecular Function | metal ion binding | |
Biological Process | fatty acid biosynthetic process | |
Biological Process | lipid oxidation | |
Biological Process | oxylipin biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLinoleate 9S-lipoxygenase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fabales > Fabaceae > Papilionoideae > 50 kb inversion clade > NPAAA clade > indigoferoid/millettioid clade > Phaseoleae > Phaseolus
Accessions
- Primary accessionP27480
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000220715 | 1-862 | Linoleate 9S-lipoxygenase 1 | |||
Sequence: MFGILNRGHKIKGTVVLMTKNVFDFNEFVSTTRGGIVGAAGGLFGAATDIVGGIVDGATAIFSRNIAIQLISATKTDGLGNGKVGKQTFLEKHLPSLPNLGDRQDAFNVYFEWDENFGIPEAFYIKNFMQSEFFLVSLTLEDIPNHGTIHFVCNSWVYNAKSYKRDRIFFANKTYLPNETPASLVKYRKEELENLRGDGTGERKEYDRIYDYAVYNDLGNPDKNKNLARTTLGGSSDFPYPRRGRTGRKSTRKDPKCEIPTSDTYIPRDENFGHLKSGDFLTYAIKSLTQNVLPTFQKAFGFNNEFDTFEDVRGLFEGGLYLPTDVISKISPIPVLKEILRTDGEQVLKFPPPHVIRVTKSAWMTDEEFGREMLAGVNPCLIQRLQEFPPKSKLDVTVYGDQTSTMTKEHLEINLGGLTVEEALHGNRLFILDHHDAFIPYLERINDLPTAKCYATRTILFLKDDNTLKPLAIELSLPNPGGKGANSRVILPADGGAESTIWLLAKAYVVVNDSCYHQLMSHWLNTHAVMEPFVIATNRHLSVLHPIYKLLLPHYRDTMNINALARQSLINAGGVIERSFLPGEFAVEMSSAVYKSWVFTDQALPADLIKRGMAVEDPSSPYGLRLVVEDYPYAVDGLEIWDTIQTWVKDYVSLYYPTNDAVKKDTELQAWWKEAVEKGHGDLKDKPWWPKLNTPQDLIHTCSIIIWIASALHAAVNFGQYPYGGFILNRPTITRRLLPEPGTKEYGELTSNYQKAYLRTITGKVEAIVDLSVIEILSRHASDEVYLGQRDNPNWTNNIKALQAFKRFGQKLKEIEEKIMGRNKDSSLRNRNGPVKMPYTVLLPTCEDEGLTFRGIPNSISI |
Proteomic databases
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 44-171 | PLAT | ||||
Sequence: FGAATDIVGGIVDGATAIFSRNIAIQLISATKTDGLGNGKVGKQTFLEKHLPSLPNLGDRQDAFNVYFEWDENFGIPEAFYIKNFMQSEFFLVSLTLEDIPNHGTIHFVCNSWVYNAKSYKRDRIFFA | ||||||
Domain | 174-862 | Lipoxygenase | ||||
Sequence: TYLPNETPASLVKYRKEELENLRGDGTGERKEYDRIYDYAVYNDLGNPDKNKNLARTTLGGSSDFPYPRRGRTGRKSTRKDPKCEIPTSDTYIPRDENFGHLKSGDFLTYAIKSLTQNVLPTFQKAFGFNNEFDTFEDVRGLFEGGLYLPTDVISKISPIPVLKEILRTDGEQVLKFPPPHVIRVTKSAWMTDEEFGREMLAGVNPCLIQRLQEFPPKSKLDVTVYGDQTSTMTKEHLEINLGGLTVEEALHGNRLFILDHHDAFIPYLERINDLPTAKCYATRTILFLKDDNTLKPLAIELSLPNPGGKGANSRVILPADGGAESTIWLLAKAYVVVNDSCYHQLMSHWLNTHAVMEPFVIATNRHLSVLHPIYKLLLPHYRDTMNINALARQSLINAGGVIERSFLPGEFAVEMSSAVYKSWVFTDQALPADLIKRGMAVEDPSSPYGLRLVVEDYPYAVDGLEIWDTIQTWVKDYVSLYYPTNDAVKKDTELQAWWKEAVEKGHGDLKDKPWWPKLNTPQDLIHTCSIIIWIASALHAAVNFGQYPYGGFILNRPTITRRLLPEPGTKEYGELTSNYQKAYLRTITGKVEAIVDLSVIEILSRHASDEVYLGQRDNPNWTNNIKALQAFKRFGQKLKEIEEKIMGRNKDSSLRNRNGPVKMPYTVLLPTCEDEGLTFRGIPNSISI | ||||||
Region | 225-257 | Disordered | ||||
Sequence: KNLARTTLGGSSDFPYPRRGRTGRKSTRKDPKC |
Sequence similarities
Belongs to the lipoxygenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length862
- Mass (Da)97,155
- Last updated1992-08-01 v1
- Checksum24D56D1CEE3C191E