P27398 · CAND_DROME

Function

function

Has a role in eye development.
Calcium-regulated non-lysosomal thiol-protease.

Miscellaneous

Although homology to other calpains is high within the protease domain, the lack of calcium-binding sites suggests that this protein is a protease that may not be activated by calcium ions.

Features

Showing features for active site.

115942004006008001,0001,2001,400
TypeIDPosition(s)Description
Active site1079
Active site1245
Active site1265

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncalcium-dependent cysteine-type endopeptidase activity
Molecular Functionmetal ion binding
Biological Processnervous system development
Biological Processproteolysis
Biological Processvisual perception

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Calpain-D
  • EC number
  • Alternative names
    • Calcium-activated neutral proteinase D (CANP D)
    • Small optic lobes protein

Gene names

    • Name
      sol
    • Synonyms
      CalpD
    • ORF names
      CG1391

Organism names

  • Taxonomic identifier
  • Strains
    • Canton-S
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    P27398
  • Secondary accessions
    • O61346
    • Q7KU57
    • Q7KU58
    • Q8MQP3
    • Q9VRH3
    • Q9VRH4

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Mutants cause specific cells to degenerate in the developing optic lobes, resulting in the absence of certain classes of columnar neurons.

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002077331-1594Calpain-D
Modified residue250Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Developmental stage

Present throughout development, with expression levels lower in larvae than other life stages.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for zinc finger, region, compositional bias, domain.

TypeIDPosition(s)Description
Zinc finger1-35RanBP2-type 1
Zinc finger135-164RanBP2-type 2
Region210-256Disordered
Compositional bias234-256Polar residues
Region371-400Disordered
Region420-459Disordered
Compositional bias439-459Polar residues
Region524-543Disordered
Compositional bias529-543Polar residues
Region554-606Disordered
Compositional bias569-594Basic and acidic residues
Zinc finger643-673RanBP2-type 3
Region684-703Disordered
Zinc finger704-733RanBP2-type 4
Zinc finger744-774RanBP2-type 5
Region786-811Disordered
Compositional bias860-876Polar residues
Region860-884Disordered
Zinc finger927-956RanBP2-type 6
Domain1014-1321Calpain catalytic

Sequence similarities

Belongs to the peptidase C2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

P27398-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,594
  • Mass (Da)
    174,313
  • Last updated
    2004-10-25 v2
  • Checksum
    1CDDE8090B5DA198
MGTISSVLQWSCTKCNTINPTESLKCFNCGTVRKVFPQQQQQQHRSSSITASWTADDALEQEQAEKGQERDKEKGRAAVARSEYKHVYKSLLRGCLKRPQRNSQNLPANCVDCEDTRKYIKSSIELYRHFSNPALNRRWVCHACGTDNSSVTWHCLICDTVSYLAPIYKDAIAADRGQDLAGSLGNRGELLAADHSHPHHHHHYLHQELEEQHQHQLHSQHLHKRHLKGRSASGSGSGPGSGSGLRRTQSLSTAIDKSASGRSCHICYANNQSKDIFNLPQIKPAPQLTGIPPVAACSNSRFAIANDTFCRRKQNNNNKNQNHKVVRESGAKRKYNFTITTLSRSAAKDAGHGQMKPLRQVVNLNLNLQQEPQQKSPANPQQLQRKTQREPAAVSMNPTQFTIPRNGVFIAVNEWSEPMASSSSVSSSSNHHHHHHSNSNSNSSGNSNIINNNSSSSSGSNKLYENECVALAQQQLRAAAAQAAQAAATAVAIASSPSAKAMAEPAPTATMPIYAQVNKQHKLKKKQQIASESQTNNNTGSGEIADAVSESLTAGLGTSTDGSGEASESESQVEEHSIYAKVWKGPRKATESKIMHDPGSSSRLSGAASAAAGTASAGAIAAAVGAAAASRHDNKTQLGNGSRSKMWICIKCSYAYNRLWLQTCEMCEAKAEQQQQQLQLQQQQQQQQQHHHHHLQQQQAEAPRDEPWTCKKCTLVNYSTAMACVVCGGSKLKSISSIEDMTLRKGEFWTCSHCTLKNSLHSPVCSACKSHRQPQLSMAMEAVRERPDGQSYEEQDAAAVGGGGGSAHQSGANEVKAPTALNLPLTSVALPMPMLQLPTSTAAGLRGSRSPSPRMQLLPSLQQQRNSSSSGAIPKRHSTGGSIVPRNISIAGLANYNLQQGQGVGSASVVSASGAGSGAGAVGASTSTKKWQCPACTYDNCAASVVCDICSSPRGLASAVLGEALGRKSVRVALTPADIRQESKLMENLRQLEETEALTKWQNIIQYCRDNSELFVDDSFPPAPKSLYYNPASGAGEGNPVVQWRRPHEINCDGGAYPPWAVFRTPLPSDICQGVLGNCWLLSALAVLAEREDLVKEVLVTKEICGQGAYQVRLCKDGKWTTVLVDDLLPCDKRGHLVYSQAKRKQLWVPLIEKAVAKIHGCYEALVSGRAIEGLATLTGAPCESIPLQASSLPMPSEDELDKDLIWAQLLSSRCVRFLMGASCGGGNMKVDEEEYQQKGLRPRHAYSVLDVKDIQGHRLLKLRNPWGHYSWRGDWSDDSSLWTDDLRDALMPHGASEGVFWISFEDVLNYFDCIDICKVRSGWNEVRLQGTLQPLCSISCVLLTVLEPTEAEFTLFQEGQRNSEKSQRSQLDLCVVIFRTRSPAAPEIGRLVEHSKRQVRGFVGCHKMLERDIYLLVCLAFNHWHTGIEDPHQYPQCILAIHSSKRLLVEQISPSPHLLADAIISLTLTKGQRHEGREGMTAYYLTKGWAGLVVMVENRHENKWIHVKCDCQESYNVVSTRGELKTVDSVPPLQRQVIIVLTQLEGSGGFSIAHRLTHRLANSRGLHDWGPPGATHCPPIENVHGLHAPRLIT

P27398-2

P27398-5

  • Name
    E
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
E1JJ98E1JJ98_DROMEsol1593

Sequence caution

The sequence AAS65411.2 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias, sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Compositional bias234-256Polar residues
Sequence conflict384in Ref. 1; AAB95431
Alternative sequenceVSP_011791394-395in isoform A
Alternative sequenceVSP_005246396-1594in isoform A
Compositional bias439-459Polar residues
Compositional bias529-543Polar residues
Compositional bias569-594Basic and acidic residues
Sequence conflict623in Ref. 1; AAB95431
Sequence conflict679in Ref. 1; AAB95431
Sequence conflict694in Ref. 1; AAB95431 and 2; AAC28409
Alternative sequenceVSP_058143701in isoform E
Sequence conflict836in Ref. 5; AAM75061
Compositional bias860-876Polar residues
Sequence conflict915in Ref. 2; AAC28409
Sequence conflict928in Ref. 1; AAB95431 and 2; AAC28409

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M64084
EMBL· GenBank· DDBJ
AAB95431.1
EMBL· GenBank· DDBJ
mRNA
AF017777
EMBL· GenBank· DDBJ
AAC28409.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014298
EMBL· GenBank· DDBJ
AAF50826.4
EMBL· GenBank· DDBJ
Genomic DNA
AE014298
EMBL· GenBank· DDBJ
AAF50827.3
EMBL· GenBank· DDBJ
Genomic DNA
AE014298
EMBL· GenBank· DDBJ
AAS65411.2
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AY128468
EMBL· GenBank· DDBJ
AAM75061.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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