P27092 · INHBA_CHICK

  • Protein
    Inhibin beta A chain
  • Gene
    INHBA
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Induces somatostatin in the ciliary ganglion neurons and may play a role in regulating neurotransmitter phenotype.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentactivin A complex
Cellular Componentextracellular region
Cellular Componentextracellular space
Cellular Componentinhibin A complex
Molecular Functioncytokine activity
Molecular Functiongrowth factor activity
Molecular Functionhormone activity
Biological Processactivin receptor signaling pathway
Biological Processhematopoietic progenitor cell differentiation
Biological Processhemoglobin biosynthetic process
Biological Processmale gonad development
Biological Processmesoderm development
Biological Processnegative regulation of cell growth
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of G1/S transition of mitotic cell cycle
Biological Processovarian follicle development
Biological Processpositive regulation of erythrocyte differentiation
Biological Processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processprogesterone secretion
Biological Processregulation of follicle-stimulating hormone secretion
Biological Processregulation of transcription by RNA polymerase II
Biological Processroof of mouth development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Inhibin beta A chain
  • Alternative names
    • Activin beta-A chain

Gene names

    • Name
      INHBA

Organism names

  • Taxonomic identifier
  • Strain
    • White leghorn
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    P27092
  • Secondary accessions
    • Q90697

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for signal, propeptide, glycosylation, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-20
PropeptidePRO_000003370421-308
Glycosylation165N-linked (GlcNAc...) asparagine
ChainPRO_0000033705309-424Inhibin beta A chain
Disulfide bond312↔320
Disulfide bond319↔389
Disulfide bond348↔421
Disulfide bond352↔423
Disulfide bond388Interchain

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Ciliary ganglion neurons. Levels are higher in the choroid than the iris.

Developmental stage

Levels increase in the iris from embryonic day 9 (9 dpc) to 16 dpc and in the choroid, levels are high from 9 dpc to 14 dpc but drop at 16 dpc.

Interaction

Subunit

Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region178-200Disordered
Compositional bias186-200Basic and acidic residues
Region260-288Disordered

Sequence similarities

Belongs to the TGF-beta family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    424
  • Mass (Da)
    47,574
  • Last updated
    1995-11-01 v2
  • Checksum
    96E158FE119E1D69
MPLLWKRGFLLVICWIIVRSSPTPGSEGHSSVADCPSCALTTLSKDVPSSQPEMVEAVKKHILNMLHLRDRPNITQPVPKAALLNATKKLHVGKVGDDGYVEIEDDVGRRAEMNEVVEQTSEIITFAESGTPKKTLHFEISKEGSELSVVEHAEVWLFLKVSKANRSRTKVTIRLFQQQRQPKGNSEAAEDMEDMGLKGERSETLISEKAVDARKSTWHIFPISSSVQRLLDQGQSSLDVRIACDLCQETGASLVLLGKKKKKEDDGEGKEKDGGELTGEEEKEQSHRPFLMMLARHSEDRQHRRRERGLECDGKVNICCKKQFFVSFKDIGWSDWIIAPTGYHANYCEEECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict33in Ref. 2; AAC59738
Sequence conflict87in Ref. 2; AAC59738
Compositional bias186-200Basic and acidic residues
Sequence conflict188in Ref. 2; AAC59738
Sequence conflict213in Ref. 2; AAC59738
Sequence conflict235in Ref. 2; AAC59738
Sequence conflict307in Ref. 2; AAC59738
Sequence conflict350in Ref. 2; AAC59738

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U26946
EMBL· GenBank· DDBJ
AAA68174.1
EMBL· GenBank· DDBJ
mRNA
U42377
EMBL· GenBank· DDBJ
AAC59738.1
EMBL· GenBank· DDBJ
mRNA
M61167
EMBL· GenBank· DDBJ
AAA48569.1
EMBL· GenBank· DDBJ
mRNA
M57407
EMBL· GenBank· DDBJ
AAA03080.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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