P26841 · CAT4_PSEAE
- ProteinChloramphenicol acetyltransferase
- Genecat
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids212 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
This enzyme is an effector of chloramphenicol (Cm) resistance in bacteria. Acetylates Cm but not 1-acetoxy-Cm.
Catalytic activity
- chloramphenicol + acetyl-CoA = chloramphenicol 3-acetate + CoA
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 79 | |||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | chloramphenicol O-acetyltransferase activity | |
Biological Process | response to antibiotic |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameChloramphenicol acetyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionP26841
- Secondary accessions
Proteomes
Organism-specific databases
Phenotypes & Variants
Chemistry
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000068661 | 1-212 | Chloramphenicol acetyltransferase | |||
Sequence: MGNYFESPFRGKLLSEQVSNPNIRVGRYSYYSGYYHGHSFDDCARYLMPDRDDVDKLVIGSFCSIGSGAAFIMAGNQGHRAEWASTFPFHFMHEEPVFAGAVNGYQPAGDTLIGHDVWIGTEAMFMPGVRVGHGAIIGSRALVTGDVEPYAIVGGNPARTIRKRFSDGDIQNLLEMAWWDWPLADIEAAMPLLCTGDIPALYRHWKQRQATA |
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length212
- Mass (Da)23,525
- Last updated2001-01-11 v3
- Checksum306EEF39978C19FC
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 97 | in Ref. 3 | ||||
Sequence: V → A | ||||||
Sequence conflict | 116 | in Ref. 3 | ||||
Sequence: D → E | ||||||
Sequence conflict | 203 | in Ref. 3 | ||||
Sequence: R → Q |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF036933 EMBL· GenBank· DDBJ | AAD02068.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE004091 EMBL· GenBank· DDBJ | AAG04095.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X12366 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |