P26640 · SYVC_HUMAN

  • Protein
    Valine--tRNA ligase
  • Gene
    VARS1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Catalyzes the attachment of valine to tRNA(Val).

Catalytic activity

Activity regulation

Can be regulated by protein kinase C-dependent phosphorylation.

Features

Showing features for binding site.

112641002003004005006007008009001,0001,1001,200
TypeIDPosition(s)Description
Binding site865ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionaminoacyl-tRNA editing activity
Molecular FunctionATP binding
Molecular Functionvaline-tRNA ligase activity
Biological ProcesstRNA aminoacylation for protein translation
Biological Processvalyl-tRNA aminoacylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Valine--tRNA ligase
  • EC number
  • Alternative names
    • Protein G7a
    • Valyl-tRNA synthetase (ValRS)

Gene names

    • Name
      VARS1
    • Synonyms
      G7A, VARS, VARS2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    P26640
  • Secondary accessions
    • B0V1N1
    • B4DZ61
    • Q5JQ90
    • Q96E77
    • Q9UQM2

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Involvement in disease

Neurodevelopmental disorder with microcephaly, seizures, and cortical atrophy (NDMSCA)

  • Note
    • The disease may be caused by variants affecting the gene represented in this entry
  • Description
    An autosomal recessive neurodevelopmental disorder characterized by severe developmental delay, intellectual disability, severe microcephaly, and cortical atrophy.
  • See also
    MIM:617802
Natural variants in NDMSCA
Variant IDPosition(s)ChangeDescription
VAR_080602885L>Fin NDMSCA; uncertain significance; dbSNP:rs1060499734
VAR_0806031058R>Qin NDMSCA; uncertain significance; dbSNP:rs769369302

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_05264751in dbSNP:rs2607015
Natural variantVAR_06190951in dbSNP:rs2753960
Natural variantVAR_052648181in dbSNP:rs35196751
Natural variantVAR_052649626in dbSNP:rs11531
Natural variantVAR_080602885in NDMSCA; uncertain significance; dbSNP:rs1060499734
Natural variantVAR_0526501008in dbSNP:rs1076827
Natural variantVAR_0806031058in NDMSCA; uncertain significance; dbSNP:rs769369302

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2,180 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Initiator methionine1UniProtRemoved
Modified residue2UniProtN-acetylserine
ChainPRO_00001062532-1264UniProtValine--tRNA ligase
Modified residue (large scale data)5PRIDEPhosphotyrosine
Modified residue (large scale data)280PRIDEPhosphotyrosine
Modified residue (large scale data)284PRIDEPhosphothreonine
Modified residue (large scale data)301PRIDEPhosphoserine
Modified residue437UniProtPhosphoserine
Modified residue (large scale data)469PRIDEPhosphotyrosine
Modified residue (large scale data)502PRIDEPhosphoserine
Modified residue (large scale data)525PRIDEPhosphoserine
Modified residue527UniProtPhosphoserine
Modified residue (large scale data)527PRIDEPhosphoserine
Modified residue (large scale data)570PRIDEPhosphoserine
Modified residue (large scale data)617PRIDEPhosphoserine
Modified residue645UniProtN6-acetyllysine
Modified residue (large scale data)1227PRIDEPhosphotyrosine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Forms high-molecular-mass aggregates with elongation factor 1.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P26640CALCOCO2 Q131373EBI-355765, EBI-739580
BINARY P26640CAMK2A Q9UQM73EBI-355765, EBI-1383687
BINARY P26640CAMK2B Q13554-33EBI-355765, EBI-11523526

Protein-protein interaction databases

Chemistry

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias, motif.

TypeIDPosition(s)Description
Domain89-219GST C-terminal
Region217-296Disordered
Compositional bias233-249Basic and acidic residues
Compositional bias262-277Basic and acidic residues
Motif344-354'HIGH' region
Motif862-866'KMSKS' region

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

P26640-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,264
  • Mass (Da)
    140,476
  • Last updated
    2000-12-01 v4
  • Checksum
    95CCDDBB3AB148AD
MSTLYVSPHPDAFPSLRALIAARYGEAGEGPGWGGAHPRICLQPPPTSRTPFPPPRLPALEQGPGGLWVWGATAVAQLLWPAGLGGPGGSRAAVLVQQWVSYADTELIPAACGATLPALGLRSSAQDPQAVLGALGRALSPLEEWLRLHTYLAGEAPTLADLAAVTALLLPFRYVLDPPARRIWNNVTRWFVTCVRQPEFRAVLGEVVLYSGARPLSHQPGPEAPALPKTAAQLKKEAKKREKLEKFQQKQKIQQQQPPPGEKKPKPEKREKRDPGVITYDLPTPPGEKKDVSGPMPDSYSPRYVEAAWYPWWEQQGFFKPEYGRPNVSAANPRGVFMMCIPPPNVTGSLHLGHALTNAIQDSLTRWHRMRGETTLWNPGCDHAGIATQVVVEKKLWREQGLSRHQLGREAFLQEVWKWKEEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSAAVTEAFVRLHEEGIIYRSTRLVNWSCTLNSAISDIEVDKKELTGRTLLSVPGYKEKVEFGVLVSFAYKVQGSDSDEEVVVATTRIETMLGDVAVAVHPKDTRYQHLKGKNVIHPFLSRSLPIVFDEFVDMDFGTGAVKITPAHDQNDYEVGQRHGLEAISIMDSRGALINVPPPFLGLPRFEARKAVLVALKERGLFRGIEDNPMVVPLCNRSKDVVEPLLRPQWYVRCGEMAQAASAAVTRGDLRILPEAHQRTWHAWMDNIREWCISRQLWWGHRIPAYFVTVSDPAVPPGEDPDGRYWVSGRNEAEAREKAAKEFGVSPDKISLQQDEDVLDTWFSSGLFPLSILGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGRLPFREVYLHAIVRDAHGRKMSKSLGNVIDPLDVIYGISLQGLHNQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGLCAYMSQGRDINLDVNRILGYRHFCNKLWNATKFALRGLGKGFVPSPTSQPGGHESLVDRWIRSRLTEAVRLSNQGFQAYDFPAVTTAQYSFWLYELCDVYLECLKPVLNGVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRMPQAPPSLCVTPYPEPSECSWKDPEAEAALELALSITRAVRSLRADYNLTRIRPDCFLEVADEATGALASAVSGYVQALASAGVVAVLALGAPAPQGCAVALASDRCSIHLQLQGLVDPARELGKLQAKRVEAQRQAQRLRERRAASGYPVKVPLEVQEADEAKLQQTEAELRKVDEAIALFQKML

P26640-2

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A2ABF4A2ABF4_HUMANVARS1174
H0Y426H0Y426_HUMANVARS1288
A0A140T936A0A140T936_HUMANVARS11183
A0A140T954A0A140T954_HUMANVARS1366
A0A140T904A0A140T904_HUMANVARS195
A0A0G2JJT9A0A0G2JJT9_HUMANVARS1174

Sequence caution

The sequence CAA41990.1 differs from that shown. Reason: Frameshift

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0564801-295in isoform 2
Sequence conflict51in Ref. 1; CAA41990 and 7; AAH12808
Compositional bias233-249Basic and acidic residues
Compositional bias262-277Basic and acidic residues
Sequence conflict331in Ref. 10; AAA81332
Alternative sequenceVSP_056481589-592in isoform 2
Sequence conflict590in Ref. 1; CAA41990
Alternative sequenceVSP_056482593-1264in isoform 2
Sequence conflict792in Ref. 1; CAA41990
Sequence conflict1064in Ref. 10; AAA81332
Sequence conflict1169in Ref. 10; AAA81332

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X59303
EMBL· GenBank· DDBJ
CAA41990.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AF134726
EMBL· GenBank· DDBJ
AAD21819.1
EMBL· GenBank· DDBJ
Genomic DNA
BA000025
EMBL· GenBank· DDBJ
BAB63303.1
EMBL· GenBank· DDBJ
Genomic DNA
AK302762
EMBL· GenBank· DDBJ
BAG63973.1
EMBL· GenBank· DDBJ
mRNA
AL662834
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL662899
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL671762
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CR925765
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471081
EMBL· GenBank· DDBJ
EAX03523.1
EMBL· GenBank· DDBJ
Genomic DNA
BC012808
EMBL· GenBank· DDBJ
AAH12808.1
EMBL· GenBank· DDBJ
mRNA
M98326
EMBL· GenBank· DDBJ
AAA81332.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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