P26405 · RFBK_SALTY
- ProteinPhosphomannomutase
- GenerfbK
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids477 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS group B O antigen.
Catalytic activity
- alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.
Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 111 | Phosphoserine intermediate | |||
Binding site | 111 | Mg2+ (UniProtKB | ChEBI); via phosphate group | |||
Binding site | 245 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 247 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 249 | Mg2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Molecular Function | magnesium ion binding | |
Molecular Function | phosphoglucosamine mutase activity | |
Molecular Function | phosphomannomutase activity | |
Biological Process | GDP-mannose biosynthetic process | |
Biological Process | O antigen biosynthetic process | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | UDP-N-acetylglucosamine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphomannomutase
- EC number
- Short namesPMM
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionP26405
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 30-46 | Helical | |||
Transmembrane | 265-284 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000147826 | 1-477 | Phosphomannomutase | ||
Keywords
- PTM
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length477
- Mass (Da)52,086
- Last updated1992-08-01 v1
- MD5 ChecksumCFF172B76C8E432C1DD477CC7AFDBE57
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X56793 EMBL· GenBank· DDBJ | CAA40129.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE006468 EMBL· GenBank· DDBJ | AAL20987.1 EMBL· GenBank· DDBJ | Genomic DNA |