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P26405 · RFBK_SALTY

Function

function

Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS group B O antigen.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.
Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site111Phosphoserine intermediate
Binding site111Mg2+ (UniProtKB | ChEBI); via phosphate group
Binding site245Mg2+ (UniProtKB | ChEBI)
Binding site247Mg2+ (UniProtKB | ChEBI)
Binding site249Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular Functionmagnesium ion binding
Molecular Functionphosphoglucosamine mutase activity
Molecular Functionphosphomannomutase activity
Biological ProcessGDP-mannose biosynthetic process
Biological ProcessO antigen biosynthetic process
Biological Processpeptidoglycan biosynthetic process
Biological ProcessUDP-N-acetylglucosamine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphomannomutase
  • EC number
  • Short names
    PMM

Gene names

    • Name
      rfbK
    • Ordered locus names
      STM2083

Organism names

Accessions

  • Primary accession
    P26405

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-46Helical
Transmembrane265-284Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001478261-477Phosphomannomutase

Keywords

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the phosphohexose mutase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    477
  • Mass (Da)
    52,086
  • Last updated
    1992-08-01 v1
  • MD5 Checksum
    CFF172B76C8E432C1DD477CC7AFDBE57
MNVVNNSRDVIYSSGIVFGTSGARGLVKDFTPQVCAAFTVSFVAVMQEHFSFDTVALAIDNRPSSYGMAQACAAALADKGVNCIFYGVVPTPALAFQSMSDNMPAIMVTGSHIPFERNGLKFYRPDGEITKHDEAAILSVEDTCSHLELKELIVSEMAAVNYISRYTSLFSTPFLKNKRIGIYEHSSAGRDLYKPLFIALGAEVVSLGRSDNFVPIDTEAVSKEDREKARSWAKEFDLDAIFSTDGDGDRPLIADEAGEWLRGDILGLLCSLALDAEAVAIPVSCNSIISSGRFFKHVKLTKIGSPYVIEAFNELSRSYSRIVGFEANGGFLLGSDICINEQNLHALPTRDAVLPAIMLLYKSRNTSISALVNELPTRYTHSDRLQGITTDKSQSLISMGRENLSNLLSYIGLENEGAISTDMTDGMRITLRDGCIVHLRASGNAPELRCYAEANLLNRAQDLVNTTLANIKKRCLL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X56793
EMBL· GenBank· DDBJ
CAA40129.1
EMBL· GenBank· DDBJ
Genomic DNA
AE006468
EMBL· GenBank· DDBJ
AAL20987.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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