P26338 · CYAA_TRYEQ
- ProteinReceptor-type adenylate cyclase
- GeneESAG4C
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids469 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Could act as a receptor for an unknown ligand.
Catalytic activity
- ATP = 3',5'-cyclic AMP + diphosphate
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | adenylate cyclase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | cAMP biosynthetic process | |
Biological Process | intracellular signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameReceptor-type adenylate cyclase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma
Accessions
- Primary accessionP26338
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-59 | Extracellular | ||||
Sequence: VDTAEKLSKNGCASNYGATQISVWSMARALNASIPPLTNPMTPSMTFRNSNAGRISGVA | ||||||
Transmembrane | 60-80 | Helical | ||||
Sequence: LVGVIIGGALALFLVVALGVV | ||||||
Topological domain | 81-469 | Cytoplasmic | ||||
Sequence: PYFFLHNTRDNNLAPKELTDPVTLIFTDIESSTALWAAHPELMPDAVATHHRLIRSLIGRYGCYEVKTVGDSFMIASKSPFAAVQLAQELQLCFLHHDWGTNAIDESYQQLEQQRAEEDAKYTPPTARLDLKVYSRLWNGLRVRVGIHTGLCDIRRDEVTKGYDYYGRTSNMAARTESVGNGGQVLMTTAAYMSLSAEEREQIDVTALGDVPLRGVAKPVEMYQLNAVPGRTFAGLRLEHELLNDDEDQTTTSCSDHSSSRTDLSVAAQTIAASLQSLLGTFTPAQRQKALIPFCERWRVPLPQKVGNVWDNDGCQEAIRRVAAKVGRVMDFGTRKASSSVTSLERGGSLFSAGGATVATVASSSNFSCVDGRCGTVQLIDLENDSTTS |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000195741 | 1-469 | Receptor-type adenylate cyclase | |||
Sequence: VDTAEKLSKNGCASNYGATQISVWSMARALNASIPPLTNPMTPSMTFRNSNAGRISGVALVGVIIGGALALFLVVALGVVPYFFLHNTRDNNLAPKELTDPVTLIFTDIESSTALWAAHPELMPDAVATHHRLIRSLIGRYGCYEVKTVGDSFMIASKSPFAAVQLAQELQLCFLHHDWGTNAIDESYQQLEQQRAEEDAKYTPPTARLDLKVYSRLWNGLRVRVGIHTGLCDIRRDEVTKGYDYYGRTSNMAARTESVGNGGQVLMTTAAYMSLSAEEREQIDVTALGDVPLRGVAKPVEMYQLNAVPGRTFAGLRLEHELLNDDEDQTTTSCSDHSSSRTDLSVAAQTIAASLQSLLGTFTPAQRQKALIPFCERWRVPLPQKVGNVWDNDGCQEAIRRVAAKVGRVMDFGTRKASSSVTSLERGGSLFSAGGATVATVASSSNFSCVDGRCGTVQLIDLENDSTTS | ||||||
Glycosylation | 31 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 103-257 | Guanylate cyclase | ||||
Sequence: TLIFTDIESSTALWAAHPELMPDAVATHHRLIRSLIGRYGCYEVKTVGDSFMIASKSPFAAVQLAQELQLCFLHHDWGTNAIDESYQQLEQQRAEEDAKYTPPTARLDLKVYSRLWNGLRVRVGIHTGLCDIRRDEVTKGYDYYGRTSNMAARTE |
Sequence similarities
Belongs to the adenylyl cyclase class-3 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length469
- Mass (Da)50,819
- Last updated1992-05-01 v1
- ChecksumF87638C3152DEA3A
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: V |