P26153 · ACHB4_CHICK

  • Protein
    Neuronal acetylcholine receptor subunit beta-4
  • Gene
    CHRNB4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Features

Showing features for site.

147050100150200250300350400450
TypeIDPosition(s)Description
Site114Key residue for a low dissociation (K(off)) from the conotoxin BuIA

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentacetylcholine-gated channel complex
Cellular Componentneuron projection
Cellular Componentplasma membrane
Cellular Componentpostsynaptic membrane
Cellular Componentsynapse
Molecular Functionacetylcholine receptor activity
Molecular Functionacetylcholine-gated monoatomic cation-selective channel activity
Biological Processacetylcholine receptor signaling pathway
Biological Processmembrane depolarization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Neuronal acetylcholine receptor subunit beta-4
  • Alternative names
    • Neuronal acetylcholine receptor non-alpha-3 chain (N-alpha 3)

Gene names

    • Name
      CHRNB4

Organism names

  • Taxonomic identifier
  • Strain
    • White leghorn
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    P26153

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain4-216Extracellular
Transmembrane217-237Helical
Topological domain238-245Cytoplasmic
Transmembrane246-266Helical
Topological domain267-278Extracellular
Transmembrane279-299Helical
Topological domain300-438Cytoplasmic
Transmembrane439-459Helical
Topological domain460-470Extracellular

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

Type
IDPosition(s)Description
Signal1-3
ChainPRO_00000003924-470Neuronal acetylcholine receptor subunit beta-4
Glycosylation29N-linked (GlcNAc...) asparagine
Glycosylation118N-linked (GlcNAc...) asparagine
Disulfide bond133↔147
Glycosylation146N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Developmental stage

High levels in the developing ciliary and superior cervical ganglia.

Interaction

Subunit

Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (also called beta). A functional receptor seems to consist of two alpha-chains and three non-alpha chains. The pentamer alpha3-beta-4 interacts with the conotoxin BuIA.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY P26153CHRNA3 P094813EBI-10686176, EBI-10686191
BINARY P26153CHRNA5 P261524EBI-10686176, EBI-10686157

Complex viewer

View interactors in UniProtKB
View CPX-184 in Complex Portal

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    470
  • Mass (Da)
    53,785
  • Last updated
    1992-05-01 v1
  • Checksum
    3117314772886B2D
STAADAEEKLMNHLLSPDRYNKLIRPAVNSSQLVSIELQVSLAQLISVNEREQIMTTNVWLNQEWIDYRLAWKPSDYEGINMLRIPAKHIWLPDIVLYNNADGTYEVSLYTNAIVQNNGSIRWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKTSMASMDDFTPSGEWDIVALPGRRTENPLDPNYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMPPWVKLVFLERLPAYLFMKRPENNSPRQKPANCKKTRAENLCMDPADFYKNSTYFVNTASAKKYDMKITDTLDNVSSHQDFRLRTGTKFSPEVQEAIDGVSFIAEHMKSDDNDQSVIEDWKYVAMVVDRLFLWIFVLVCVLGTVGLFLQPLFQNHIAATNP

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
J05643
EMBL· GenBank· DDBJ
-mRNA No translation available.

Similar Proteins

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