P26150 · 3BHS3_MOUSE
- Protein3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3
- GeneHsd3b3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids373 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta5-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
Catalytic activity
- a 3beta-hydroxy-Delta5-steroid + NAD+ = a 3-oxo-Delta5-steroid + H+ + NADH
Pathway
Lipid metabolism; steroid biosynthesis.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | intracellular membrane-bounded organelle | |
Cellular Component | mitochondrial inner membrane | |
Molecular Function | 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity | |
Molecular Function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | |
Molecular Function | steroid delta-isomerase activity | |
Biological Process | androgen biosynthetic process | |
Biological Process | C21-steroid hormone biosynthetic process | |
Biological Process | C21-steroid hormone metabolic process | |
Biological Process | hippocampus development | |
Biological Process | negative regulation of iron ion transport | |
Biological Process | response to corticosterone | |
Biological Process | steroid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3
- Alternative names
Including 2 domains:
- Recommended name3-beta-hydroxy-Delta(5)-steroid dehydrogenase
- EC number
- Alternative names
- Recommended nameSteroid Delta-isomerase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP26150
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass membrane protein
Mitochondrion membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 288-308 | Helical | ||||
Sequence: VPILYWLAFLLETVSFLLSPI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000087782 | 1-373 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3 | |||
Sequence: MPGWSCLVTGAGGFLGQRIIQLLVQEKDLEEIRVLDKVFKPETREQFFNLGTSIKVTVLEGDILDTQYLRRACQGISVVIHTAAIIDVTGVIPRQTILDVNLKGTQNLLEACIQASVPAFIFSSSVDVAGPNSYKDIVLNGHEDEHRESTWSDPYPYSKKMAEKAVLAANGSMLKNGGTLQTCALRPMCIYGERSQFLSNTIIKALKNKFILRGGGKFSTANPVYVGNVAWAHILAARGLRNPKKSPNIQGEFYYISDDTPHQSYDDLNYTLSKEWGFCLNSRWYLPVPILYWLAFLLETVSFLLSPIYRYIPPFNRHLVTLTASTFTFSYKKAQRDLGYEPLVSWEEAKQKTSEWIGTLVEQHRETLDTKSQ |
Proteomic databases
PTM databases
Expression
Tissue specificity
Liver and kidney. Greater expression in liver.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length373
- Mass (Da)42,031
- Last updated2007-01-23 v3
- Checksum6F320FF1707974A6
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M77015 EMBL· GenBank· DDBJ | - | mRNA | No translation available. |