P26149 · 3BHS2_MOUSE

  • Protein
    3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
  • Gene
    Hsd3b2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta5-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.

Catalytic activity

Pathway

Lipid metabolism; steroid biosynthesis.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site155Proton acceptor
Binding site159NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Cellular Componentintracellular membrane-bounded organelle
Cellular Componentmitochondrial membrane
Molecular Function3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity
Molecular Functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Molecular Functionsteroid delta-isomerase activity
Biological Processandrogen biosynthetic process
Biological ProcessC21-steroid hormone biosynthetic process
Biological ProcessC21-steroid hormone metabolic process
Biological Processhippocampus development
Biological Processnegative regulation of iron ion transport
Biological Processresponse to corticosterone
Biological Processsteroid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
  • Alternative names
    • 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II (3-beta-HSD II)

Including 2 domains:

  • Recommended name
    3-beta-hydroxy-Delta(5)-steroid dehydrogenase
  • EC number
  • Alternative names
    • 3-beta-hydroxy-5-ene steroid dehydrogenase
    • Progesterone reductase
  • Recommended name
    Steroid Delta-isomerase
  • EC number
  • Alternative names
    • Delta-5-3-ketosteroid isomerase

Gene names

    • Name
      Hsd3b2

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
    • BALB/cJ
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P26149
  • Secondary accessions
    • B1ARN7
    • Q8R0J6

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane288-308Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000877811-3733 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

Proteomic databases

PTM databases

Expression

Tissue specificity

Liver and kidney.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the 3-beta-HSD family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    373
  • Mass (Da)
    41,923
  • Last updated
    2011-06-28 v4
  • Checksum
    2500AF16F38C081B
MPGWSCLVTGAGGFLGQRIIQLLVQEEDLEEIRVLDKVFRPETRKEFFNLETSIKVTVLEGDILDTQYLRRACQGISVVIHTAAIIDVTGVIPRQTILDVNLKGTQNLLEACIQASVPAFIFSSSVDVAGPNSYKEIVLNGHEEECHESTWSDPYPYSKKMAEKAVLAANGSMLKNGGTLQTCALRPMCIYGERSPLISNIIIMALKHKGILRSFGKFNTANPVYVGNVAWAHILAARGLRDPKKSPNIQGEFYYISDDTPHQSFDDISYTLSKEWGFCLDSSWSLPVPLLYWLAFLLETVSFLLSPIYRYIPPFNRHLVTLSGSTFTFSYKKAQRDLGYEPLVSWEEAKQKTSEWIGTLVEQHRETLDTKSQ

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict12in Ref. 2; AAH26757/AAH40397
Sequence conflict54in Ref. 2; AAH26757/AAH40397

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL606755
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC026757
EMBL· GenBank· DDBJ
AAH26757.1
EMBL· GenBank· DDBJ
mRNA
BC040397
EMBL· GenBank· DDBJ
AAH40397.1
EMBL· GenBank· DDBJ
mRNA
M75886
EMBL· GenBank· DDBJ
-mRNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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