P25855 · GCSH1_ARATH
- ProteinGlycine cleavage system H protein 1, mitochondrial
- GeneGDH1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids165 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
The glycine decarboxylase (GDC) or glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
Cofactor
Note: Binds 1 lipoyl cofactor covalently.
Activity regulation
Inhibited by harpin, S-nitrosoglutathione (GSNO), nitric oxide, N-ethylmaleimide and 5,5'-dithiobis-(2-nitrobenzoic acid).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | glycine cleavage complex | |
Cellular Component | mitochondrion | |
Cellular Component | nucleus | |
Cellular Component | thylakoid | |
Biological Process | glycine decarboxylation via glycine cleavage system |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycine cleavage system H protein 1, mitochondrial
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionP25855
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for transit peptide, chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-34 | Mitochondrion | ||||
Sequence: MALRMWASSTANALKLSSSVSKSHLSPFSFSRCF | ||||||
Chain | PRO_0000010729 | 35-165 | Glycine cleavage system H protein 1, mitochondrial | |||
Sequence: STVLEGLKYANSHEWVKHEGSVATIGITAHAQDHLGEVVFVELPEDNTSVSKEKSFGAVESVKATSEILSPISGEIIEVNKKLTESPGLINSSPYEDGWMIKVKPSSPAELESLMGPKEYTKFCEEEDAAH | ||||||
Modified residue | 97 | N6-lipoyllysine | ||||
Sequence: K | ||||||
Modified residue | 140 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
S-nitrosylated and/or glutathionylated at unknown positions in response to nitric oxide.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in leaves, lower expression in green veins, petioles, and stems, and detected in roots.
Induction
Up-regulated by light.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 56-138 | Lipoyl-binding | ||||
Sequence: VATIGITAHAQDHLGEVVFVELPEDNTSVSKEKSFGAVESVKATSEILSPISGEIIEVNKKLTESPGLINSSPYEDGWMIKVK |
Sequence similarities
Belongs to the GcvH family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length165
- Mass (Da)17,947
- Last updated1992-05-01 v1
- Checksum48309650C88F9BE2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U27144 EMBL· GenBank· DDBJ | AAA87942.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M82921 EMBL· GenBank· DDBJ | AAA32802.1 EMBL· GenBank· DDBJ | mRNA | ||
AC005314 EMBL· GenBank· DDBJ | AAC36184.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC09100.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY050446 EMBL· GenBank· DDBJ | AAK91461.1 EMBL· GenBank· DDBJ | mRNA | ||
AY058854 EMBL· GenBank· DDBJ | AAL24242.1 EMBL· GenBank· DDBJ | mRNA | ||
AY097349 EMBL· GenBank· DDBJ | AAM19865.1 EMBL· GenBank· DDBJ | mRNA | ||
AK228462 EMBL· GenBank· DDBJ | BAF00389.1 EMBL· GenBank· DDBJ | mRNA | ||
AY086345 EMBL· GenBank· DDBJ | AAM64413.1 EMBL· GenBank· DDBJ | mRNA |