P25618 · CWH43_YEAST

Function

function

Involved in the maintenance of cell wall integrity. Required for the replacement of the diacylglycerol moiety by ceramides during GPI-anchor maturation.

Features

Showing features for active site.

1953100200300400500600700800900
TypeIDPosition(s)Description
Active site802

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcellular bud neck
Cellular Componentcellular bud tip
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Cellular Componentplasma membrane
Biological Processcell wall organization
Biological Processfungal-type cell wall organization
Biological ProcessGPI anchor biosynthetic process
Biological ProcessGPI anchor metabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein CWH43
  • Alternative names
    • Calcofluor white hypersensitive protein

Gene names

    • Name
      CWH43
    • ORF names
      YCR17C
    • Ordered locus names
      YCR017C

Organism names

Accessions

  • Primary accession
    P25618
  • Secondary accessions
    • D6VR25
    • Q8NIM1

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Note: Concentrates to the bud tip of small budded cells and to the neck of dividing cells.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-7Cytoplasmic
Topological domain29-64Extracellular
Transmembrane65-85Helical
Topological domain86-91Cytoplasmic
Transmembrane92-112Helical
Topological domain113-117Extracellular
Transmembrane118-138Helical
Topological domain139-149Cytoplasmic
Transmembrane150-170Helical
Topological domain171-175Extracellular
Transmembrane176-196Helical
Topological domain197-278Cytoplasmic
Transmembrane279-299Helical
Topological domain300-307Extracellular
Transmembrane308-328Helical
Topological domain329-330Cytoplasmic
Transmembrane331-351Helical
Topological domain352Extracellular
Transmembrane353-368Helical
Topological domain369-380Cytoplasmic
Transmembrane381-401Helical
Topological domain402-420Extracellular
Transmembrane421-441Helical
Topological domain442-450Cytoplasmic
Transmembrane451-471Helical
Topological domain472-495Extracellular
Transmembrane496-516Helical
Topological domain517Cytoplasmic
Transmembrane518-538Helical
Topological domain539-547Extracellular
Transmembrane548-568Helical
Topological domain569-585Cytoplasmic
Transmembrane586-606Helical
Topological domain607-613Extracellular
Transmembrane614-634Helical
Topological domain635-642Cytoplasmic
Transmembrane643-663Helical
Topological domain664-953Extracellular

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis57Causes destabilization of the protein and induces the release of cell wall proteins in the culture medium.
Mutagenesis472No effect on introduction of ceramides into the GPI anchor.
Mutagenesis693No effect on introduction of ceramides into the GPI anchor.
Mutagenesis713Impairs the introduction of ceramides into the GPI anchor.
Mutagenesis770No effect on introduction of ceramides into the GPI anchor.
Mutagenesis771No effect on introduction of ceramides into the GPI anchor.
Mutagenesis802Abrogates the introduction of ceramides into the GPI anchor.
Mutagenesis807No effect on introduction of ceramides into the GPI anchor.
Mutagenesis862Impairs the introduction of ceramides into the GPI anchor.
Mutagenesis882Abrogates the introduction of ceramides into the GPI anchor.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 16 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00000210521-953Protein CWH43
Glycosylation419N-linked (GlcNAc...) asparagine
Glycosylation490N-linked (GlcNAc...) asparagine
Glycosylation767N-linked (GlcNAc...) asparagine
Glycosylation792N-linked (GlcNAc...) asparagine
Glycosylation825N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-229PGAP2-like
Region230-953PGAP2IP-like
Region862-882Required for function in lipid remodeling

Domain

The PGAP2-like region interacts with the PGAP2IP-like region.

Sequence similarities

In the N-terminal section; belongs to the PGAP2 family.
In the C-terminal section; belongs to the PGAP2IP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    953
  • Mass (Da)
    107,883
  • Last updated
    2003-10-24 v2
  • Checksum
    9F56CCD85824E848
MLIINGKIIPIAHTICAFSAFFAALVTGYSLHFHKIVTNAHYTYPDEWFPSVSATIGDRYPERSIFQILIALTAFPRFLLLLGHYYLNQSKVCFLVGVLRTVSCGGWVYITSTDDHDIHDIFMITYIVLTLPWDIMITRYSSPLTSKNKGLTATIFFGTLFPMIYWYIQHSVQQRAGAYSIYAYFEWSLILLDIAFDAFAYADFKKIDIVLAFNEKPGNTSFFQIRDSSPINYGEEKSSELQKSGEKKVEKEKPVARSATGSYFRFDSFFYLLTNIFNGFLFWSNVTSLLCSIWHFPLWYMGISGYEAAILGYLGPIFLYLPFVSEAFTQYGVLLGGIIAIGAYIVQMPELRLISVAVGTSITVATFVQNLRYITNAETSFSFALTWLLGLVASVILKMGFYTNNPTWVILDERNGGYNKTALVLTVLFGMLSPYVNSINFEGKRNAQAKSASLIGKLFLAVGFGSLLFGIHQLLTDSSTTIYWAWEGYNESHGPLPWPWGALTCTVMLFASLSSVKFMGKPLVPCLLLLISTAVLSARSITQWPKYIFGGLLYAIAMLWLVPSYFSALGQVQNIWVYVLSFSVYIIFVLAHVWVVAYAFVPMGWVLREKIETVLAFSSTFIIIGALTCKNLNIQLVTMGKKFFIYVFFFAVALLSLTARFVYDIRPTGIPQPYHPDSQLITAGIWTIHFGLDNDMWASEDRMINLIKDMELDVVGLLETDTQRITMGNRDLTSKLAHDLNMYADFGPGPNKHTWGCVLLSKFPIVNSTHHLLPSPVGELAPAIHATLQTYNDTLVDVFVFHSGQEEDEEDRRLQSNYMAKLMGNTTRPAILLSYLVVDPGEGNYNTYVSETSGMHDIDPSDDDRWCEYILYRGLRRTGYARVARGTITDTELQVGKFQVLSEQALVEHSDSMYEYGHMSEPEYEDMKFPDKFLGEGERGHFYHVFDEPRYYL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X59720
EMBL· GenBank· DDBJ
CAC42972.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006937
EMBL· GenBank· DDBJ
DAA07494.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp