P25566 · MXR2_YEAST
- ProteinPeptide methionine sulfoxide reductase 2
- GeneMXR2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids168 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Methionine-R-sulfoxide reductase which catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins. Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation. Protects iron-sulfur clusters from oxidative inactivation along with MXR1. Involved in the regulation of lifespan.
Miscellaneous
Present with 799 molecules/cell in log phase SD medium.
Catalytic activity
- L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiolThis reaction proceeds in the backward direction.
RHEA-COMP:12313 + RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 = RHEA-COMP:12314 + RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 79 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 82 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 128 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 131 | Zn2+ (UniProtKB | ChEBI) | |||
Active site | 157 | Nucleophile | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | metal ion binding | |
Molecular Function | peptide-methionine (R)-S-oxide reductase activity | |
Biological Process | cellular response to oxidative stress | |
Biological Process | protein repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeptide methionine sulfoxide reductase 2
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP25566
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000140326 | 1-168 | Peptide methionine sulfoxide reductase 2 | ||
Disulfide bond | 97↔157 | Redox-active | |||
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length168
- Mass (Da)19,279
- Last updated1992-05-01 v1
- MD5 Checksum4B4D23CC3F0641D8631EB4647BB553F2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X59720 EMBL· GenBank· DDBJ | CAA42383.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006937 EMBL· GenBank· DDBJ | DAA07451.1 EMBL· GenBank· DDBJ | Genomic DNA |