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P25566 · MXR2_YEAST

Function

function

Methionine-R-sulfoxide reductase which catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins. Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation. Protects iron-sulfur clusters from oxidative inactivation along with MXR1. Involved in the regulation of lifespan.

Miscellaneous

Present with 799 molecules/cell in log phase SD medium.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site79Zn2+ (UniProtKB | ChEBI)
Binding site82Zn2+ (UniProtKB | ChEBI)
Binding site128Zn2+ (UniProtKB | ChEBI)
Binding site131Zn2+ (UniProtKB | ChEBI)
Active site157Nucleophile

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Functionmetal ion binding
Molecular Functionpeptide-methionine (R)-S-oxide reductase activity
Biological Processcellular response to oxidative stress
Biological Processprotein repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peptide methionine sulfoxide reductase 2
  • EC number

Gene names

    • Name
      MXR2
    • Synonyms
      MSRB
    • ORF names
      YCL33C
    • Ordered locus names
      YCL033C

Organism names

Accessions

  • Primary accession
    P25566
  • Secondary accessions
    • D6VQY2

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain, disulfide bond.

Type
IDPosition(s)Description
ChainPRO_00001403261-168Peptide methionine sulfoxide reductase 2
Disulfide bond97↔157Redox-active

Keywords

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain40-168MsrB

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    168
  • Mass (Da)
    19,279
  • Last updated
    1992-05-01 v1
  • MD5 Checksum
    4B4D23CC3F0641D8631EB4647BB553F2
MNKWSRLYVITVRRTFPGRRNIVLTQYWNKSKKMSDESNDVKWNDALTPLQLMVLRDKATERPNTGAYLHTNESGVYHCANCDRPLYSSKAKFDARCGWPAFYEEVSPGAITYHRDNSLMPARVEICCARCGGHLGHVFEGEGWKQLLNLPKDTRHCVNSASLNLKKD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X59720
EMBL· GenBank· DDBJ
CAA42383.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006937
EMBL· GenBank· DDBJ
DAA07451.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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