P25386 · USO1_YEAST
- ProteinIntracellular protein transport protein USO1
- GeneUSO1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1790 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required for protein transport from the ER to the Golgi complex.
Miscellaneous
Present with 2330 molecules/cell in log phase SD medium.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoskeleton | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | ER to Golgi transport vesicle membrane | |
Cellular Component | Golgi membrane | |
Cellular Component | Golgi stack | |
Biological Process | endoplasmic reticulum to Golgi vesicle-mediated transport | |
Biological Process | Golgi vesicle docking | |
Biological Process | intracellular protein transport | |
Biological Process | membrane fusion | |
Biological Process | SNARE complex assembly | |
Biological Process | vesicle fusion with Golgi apparatus |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameIntracellular protein transport protein USO1
- Short namesInt-1
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionP25386
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Golgi apparatus membrane ; Peripheral membrane protein
Note: Probably present on vesicles operational between the ER and the Golgi complex.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000065730 | 1-1790 | Intracellular protein transport protein USO1 | |||
Sequence: MDIIQGLIQQPKIQSVDETIPTLCDRVENSTLISDRRSAVLGLKAFSRQYRESVIASGLKPLLNTLKRDYMDEDSVKAILETILILFIRGDGHDDLTRGWISQQSRLQNGKYPSPLVMKQEKEQVDQFSLWIADALTQSEDLIHLLVEFWEIDNFHIRLYTIQLLEAVMATRPLKARSALISLPTSISTMVSLLDDMHEPIRDEAILLLMAVVNDSPHVQKLVAFENIFERLFSIIEEEGGLRGSLVVNDCLSLINNILKYNTSNQTLFLETGNLPKLAHLLSEPISQDEVFFWNDQRIVNINTALDIVSLTVEPGNTVTTKHQNALLDSSVLMVVLRLAFFHNIPKKVRPVALLTAANMVRSNEHAQLEFSKIDVPYFDPSLPVNSTANGGPIKLIPVVSILINWMLYANSVHTFDTRVACSRLLKAYFMDNFDLQRDFLLKQVQLCNNSTNNVGDNAKENGGSNKSDKESDSDKDTDGKDGTEYEGSFKANLFEVLLNYDAELNLNPFKLFFTTDIFMFFFQQDHKYSEELREITRNVTTGNDLEDEEPLKAIQTISELLTTSLTAADIRIPISYLTFLIYWLFGDFKATNDFLSDKSVIKSLLSFSYQIQDEDVTIKCLVTMLLGVAYEFSSKESPFPRKEYFEFITKTLGKDNYASRIKQFKKDSYFSKVDMNEDSILTPELDETGLPKVYFSTYFIQLFNENIYRIRTALSHDPDEEPINKISFEEVEKLQRQCTKLKGEITSLQTETESTHENLTEKLIALTNEHKELDEKYQILNSSHSSLKENFSILETELKNVRDSLDEMTQLRDVLETKDKENQTALLEYKSTIHKQEDSIKTLEKGLETILSQKKKAEDGINKMGKDLFALSREMQAVEENCKNLQKEKDKSNVNHQKETKSLKEDIAAKITEIKAINENLEEMKIQCNNLSKEKEHISKELVEYKSRFQSHDNLVAKLTEKLKSLANNYKDMQAENESLIKAVEESKNESSIQLSNLQNKIDSMSQEKENFQIERGSIEKNIEQLKKTISDLEQTKEEIISKSDSSKDEYESQISLLKEKLETATTANDENVNKISELTKTREELEAELAAYKNLKNELETKLETSEKALKEVKENEEHLKEEKIQLEKEATETKQQLNSLRANLESLEKEHEDLAAQLKKYEEQIANKERQYNEEISQLNDEITSTQQENESIKKKNDELEGEVKAMKSTSEEQSNLKKSEIDALNLQIKELKKKNETNEASLLESIKSVESETVKIKELQDECNFKEKEVSELEDKLKASEDKNSKYLELQKESEKIKEELDAKTTELKIQLEKITNLSKAKEKSESELSRLKKTSSEERKNAEEQLEKLKNEIQIKNQAFEKERKLLNEGSSTITQEYSEKINTLEDELIRLQNENELKAKEIDNTRSELEKVSLSNDELLEEKQNTIKSLQDEILSYKDKITRNDEKLLSIERDNKRDLESLKEQLRAAQESKAKVEEGLKKLEEESSKEKAELEKSKEMMKKLESTIESNETELKSSMETIRKSDEKLEQSKKSAEEDIKNLQHEKSDLISRINESEKDIEELKSKLRIEAKSGSELETVKQELNNAQEKIRINAEENTVLKSKLEDIERELKDKQAEIKSNQEEKELLTSRLKELEQELDSTQQKAQKSEEERRAEVRKFQVEKSQLDEKAMLLETKYNDLVNKEQAWKRDEDTVKKTTDSQRQEIEKLAKELDNLKAENSKLKEANEDRSEIDDLMLLVTDLDEKNAKYRSKLKDLGVEISSDEEDDEEDDEEDEEEGQVA | ||||||
Modified residue | 1770 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for region, repeat, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-724 | Globular head | ||||
Sequence: MDIIQGLIQQPKIQSVDETIPTLCDRVENSTLISDRRSAVLGLKAFSRQYRESVIASGLKPLLNTLKRDYMDEDSVKAILETILILFIRGDGHDDLTRGWISQQSRLQNGKYPSPLVMKQEKEQVDQFSLWIADALTQSEDLIHLLVEFWEIDNFHIRLYTIQLLEAVMATRPLKARSALISLPTSISTMVSLLDDMHEPIRDEAILLLMAVVNDSPHVQKLVAFENIFERLFSIIEEEGGLRGSLVVNDCLSLINNILKYNTSNQTLFLETGNLPKLAHLLSEPISQDEVFFWNDQRIVNINTALDIVSLTVEPGNTVTTKHQNALLDSSVLMVVLRLAFFHNIPKKVRPVALLTAANMVRSNEHAQLEFSKIDVPYFDPSLPVNSTANGGPIKLIPVVSILINWMLYANSVHTFDTRVACSRLLKAYFMDNFDLQRDFLLKQVQLCNNSTNNVGDNAKENGGSNKSDKESDSDKDTDGKDGTEYEGSFKANLFEVLLNYDAELNLNPFKLFFTTDIFMFFFQQDHKYSEELREITRNVTTGNDLEDEEPLKAIQTISELLTTSLTAADIRIPISYLTFLIYWLFGDFKATNDFLSDKSVIKSLLSFSYQIQDEDVTIKCLVTMLLGVAYEFSSKESPFPRKEYFEFITKTLGKDNYASRIKQFKKDSYFSKVDMNEDSILTPELDETGLPKVYFSTYFIQLFNENIYRIRTALSHDPDEEPI | ||||||
Repeat | 45-89 | ARM 1 | ||||
Sequence: AFSRQYRESVIASGLKPLLNTLKRDYMDEDSVKAILETILILFIR | ||||||
Repeat | 127-170 | ARM 2 | ||||
Sequence: QFSLWIADALTQSEDLIHLLVEFWEIDNFHIRLYTIQLLEAVMA | ||||||
Repeat | 173-213 | ARM 3 | ||||
Sequence: PLKARSALISLPTSISTMVSLLDDMHEPIRDEAILLLMAVV | ||||||
Repeat | 215-260 | ARM 4 | ||||
Sequence: DSPHVQKLVAFENIFERLFSIIEEEGGLRGSLVVNDCLSLINNILK | ||||||
Repeat | 261-312 | ARM 5 | ||||
Sequence: YNTSNQTLFLETGNLPKLAHLLSEPISQDEVFFWNDQRIVNINTALDIVSLT | ||||||
Repeat | 314-362 | ARM 6 | ||||
Sequence: EPGNTVTTKHQNALLDSSVLMVVLRLAFFHNIPKKVRPVALLTAANMVR | ||||||
Repeat | 363-429 | ARM 7 | ||||
Sequence: SNEHAQLEFSKIDVPYFDPSLPVNSTANGGPIKLIPVVSILINWMLYANSVHTFDTRVACSRLLKAY | ||||||
Repeat | 431-512 | ARM 8 | ||||
Sequence: MDNFDLQRDFLLKQVQLCNNSTNNVGDNAKENGGSNKSDKESDSDKDTDGKDGTEYEGSFKANLFEVLLNYDAELNLNPFKL | ||||||
Region | 452-484 | Disordered | ||||
Sequence: TNNVGDNAKENGGSNKSDKESDSDKDTDGKDGT | ||||||
Compositional bias | 463-484 | Basic and acidic residues | ||||
Sequence: GGSNKSDKESDSDKDTDGKDGT | ||||||
Region | 465-487 | Charged (hyper-hydrophilic) | ||||
Sequence: SNKSDKESDSDKDTDGKDGTEYE | ||||||
Repeat | 543-584 | ARM 9 | ||||
Sequence: GNDLEDEEPLKAIQTISELLTTSLTAADIRIPISYLTFLIYW | ||||||
Repeat | 586-630 | ARM 10 | ||||
Sequence: FGDFKATNDFLSDKSVIKSLLSFSYQIQDEDVTIKCLVTMLLGVA | ||||||
Coiled coil | 725-1790 | |||||
Sequence: NKISFEEVEKLQRQCTKLKGEITSLQTETESTHENLTEKLIALTNEHKELDEKYQILNSSHSSLKENFSILETELKNVRDSLDEMTQLRDVLETKDKENQTALLEYKSTIHKQEDSIKTLEKGLETILSQKKKAEDGINKMGKDLFALSREMQAVEENCKNLQKEKDKSNVNHQKETKSLKEDIAAKITEIKAINENLEEMKIQCNNLSKEKEHISKELVEYKSRFQSHDNLVAKLTEKLKSLANNYKDMQAENESLIKAVEESKNESSIQLSNLQNKIDSMSQEKENFQIERGSIEKNIEQLKKTISDLEQTKEEIISKSDSSKDEYESQISLLKEKLETATTANDENVNKISELTKTREELEAELAAYKNLKNELETKLETSEKALKEVKENEEHLKEEKIQLEKEATETKQQLNSLRANLESLEKEHEDLAAQLKKYEEQIANKERQYNEEISQLNDEITSTQQENESIKKKNDELEGEVKAMKSTSEEQSNLKKSEIDALNLQIKELKKKNETNEASLLESIKSVESETVKIKELQDECNFKEKEVSELEDKLKASEDKNSKYLELQKESEKIKEELDAKTTELKIQLEKITNLSKAKEKSESELSRLKKTSSEERKNAEEQLEKLKNEIQIKNQAFEKERKLLNEGSSTITQEYSEKINTLEDELIRLQNENELKAKEIDNTRSELEKVSLSNDELLEEKQNTIKSLQDEILSYKDKITRNDEKLLSIERDNKRDLESLKEQLRAAQESKAKVEEGLKKLEEESSKEKAELEKSKEMMKKLESTIESNETELKSSMETIRKSDEKLEQSKKSAEEDIKNLQHEKSDLISRINESEKDIEELKSKLRIEAKSGSELETVKQELNNAQEKIRINAEENTVLKSKLEDIERELKDKQAEIKSNQEEKELLTSRLKELEQELDSTQQKAQKSEEERRAEVRKFQVEKSQLDEKAMLLETKYNDLVNKEQAWKRDEDTVKKTTDSQRQEIEKLAKELDNLKAENSKLKEANEDRSEIDDLMLLVTDLDEKNAKYRSKLKDLGVEISSDEEDDEEDDEEDEEEGQVA | ||||||
Region | 991-1790 | Dispensable for the protein function | ||||
Sequence: ESSIQLSNLQNKIDSMSQEKENFQIERGSIEKNIEQLKKTISDLEQTKEEIISKSDSSKDEYESQISLLKEKLETATTANDENVNKISELTKTREELEAELAAYKNLKNELETKLETSEKALKEVKENEEHLKEEKIQLEKEATETKQQLNSLRANLESLEKEHEDLAAQLKKYEEQIANKERQYNEEISQLNDEITSTQQENESIKKKNDELEGEVKAMKSTSEEQSNLKKSEIDALNLQIKELKKKNETNEASLLESIKSVESETVKIKELQDECNFKEKEVSELEDKLKASEDKNSKYLELQKESEKIKEELDAKTTELKIQLEKITNLSKAKEKSESELSRLKKTSSEERKNAEEQLEKLKNEIQIKNQAFEKERKLLNEGSSTITQEYSEKINTLEDELIRLQNENELKAKEIDNTRSELEKVSLSNDELLEEKQNTIKSLQDEILSYKDKITRNDEKLLSIERDNKRDLESLKEQLRAAQESKAKVEEGLKKLEEESSKEKAELEKSKEMMKKLESTIESNETELKSSMETIRKSDEKLEQSKKSAEEDIKNLQHEKSDLISRINESEKDIEELKSKLRIEAKSGSELETVKQELNNAQEKIRINAEENTVLKSKLEDIERELKDKQAEIKSNQEEKELLTSRLKELEQELDSTQQKAQKSEEERRAEVRKFQVEKSQLDEKAMLLETKYNDLVNKEQAWKRDEDTVKKTTDSQRQEIEKLAKELDNLKAENSKLKEANEDRSEIDDLMLLVTDLDEKNAKYRSKLKDLGVEISSDEEDDEEDDEEDEEEGQVA | ||||||
Region | 1185-1221 | Disordered | ||||
Sequence: EITSTQQENESIKKKNDELEGEVKAMKSTSEEQSNLK | ||||||
Compositional bias | 1191-1221 | Basic and acidic residues | ||||
Sequence: QENESIKKKNDELEGEVKAMKSTSEEQSNLK | ||||||
Region | 1326-1351 | Disordered | ||||
Sequence: KEKSESELSRLKKTSSEERKNAEEQL | ||||||
Region | 1485-1547 | Disordered | ||||
Sequence: GLKKLEEESSKEKAELEKSKEMMKKLESTIESNETELKSSMETIRKSDEKLEQSKKSAEEDIK | ||||||
Region | 1645-1667 | Disordered | ||||
Sequence: QELDSTQQKAQKSEEERRAEVRK | ||||||
Region | 1722-1742 | Disordered | ||||
Sequence: DNLKAENSKLKEANEDRSEID | ||||||
Region | 1762-1790 | Disordered | ||||
Sequence: LKDLGVEISSDEEDDEEDDEEDEEEGQVA | ||||||
Compositional bias | 1769-1790 | Acidic residues | ||||
Sequence: ISSDEEDDEEDDEEDEEEGQVA |
Domain
Composed of a globular head region and a rod-like C-terminal coiled coil domain. The rodlike tail sequence is highly repetitive, composed of a heptapeptide repeat pattern characteristic of alpha-helical coiled coils. May form filamentous structures in the cell.
Sequence similarities
Belongs to the VDP/USO1/EDE1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,790
- Mass (Da)206,452
- Last updated2004-12-21 v2
- Checksum90062544F55A52EE
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 390-391 | in Ref. 1; CAA38253 | ||||
Sequence: NG → TA | ||||||
Compositional bias | 463-484 | Basic and acidic residues | ||||
Sequence: GGSNKSDKESDSDKDTDGKDGT | ||||||
Sequence conflict | 725 | in Ref. 1; CAA38253 | ||||
Sequence: N → S | ||||||
Sequence conflict | 847 | in Ref. 5; AAB00143 | ||||
Sequence: G → E | ||||||
Sequence conflict | 924 | in Ref. 5; AAB00143 | ||||
Sequence: E → K | ||||||
Compositional bias | 1191-1221 | Basic and acidic residues | ||||
Sequence: QENESIKKKNDELEGEVKAMKSTSEEQSNLK | ||||||
Sequence conflict | 1253 | in Ref. 5; AAB00143 | ||||
Sequence: V → I | ||||||
Sequence conflict | 1319 | in Ref. 5; AAB00143 | ||||
Sequence: I → V | ||||||
Sequence conflict | 1461 | in Ref. 5; AAB00143 | ||||
Sequence: N → S | ||||||
Sequence conflict | 1581 | in Ref. 5; AAB00143 | ||||
Sequence: G → S | ||||||
Sequence conflict | 1600 | in Ref. 5; AAB00143 | ||||
Sequence: I → V | ||||||
Sequence conflict | 1661 | in Ref. 5; AAB00143 | ||||
Sequence: R → S | ||||||
Compositional bias | 1769-1790 | Acidic residues | ||||
Sequence: ISSDEEDDEEDDEEDEEEGQVA | ||||||
Sequence conflict | 1772 | in Ref. 5; AAB00143 | ||||
Sequence: D → DEEDDEE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X54378 EMBL· GenBank· DDBJ | CAA38253.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z74105 EMBL· GenBank· DDBJ | CAA98620.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z74106 EMBL· GenBank· DDBJ | CAA98621.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
U53668 EMBL· GenBank· DDBJ | AAB66659.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
L03188 EMBL· GenBank· DDBJ | AAB00143.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006938 EMBL· GenBank· DDBJ | DAA11798.1 EMBL· GenBank· DDBJ | Genomic DNA |