P25376 · AGP1_YEAST

Function

function

Broad substrate range permease which transports asparagine and glutamine with intermediate specificity. Also transports Ala, Cys, Gly, Ile, Leu, Met, Phe, Ser, Thr, Tyr and Val. Important for the utilization of amino acids as a nitrogen source.

Miscellaneous

Present with 21100 molecules/cell in log phase SD medium.

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
0.23 mMleucine
Vmax pH TEMPERATURE[C] NOTES EVIDENCE
2.6 nmol/min/mgfor leucine transport

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentmembrane
Cellular Componentplasma membrane
Molecular Functionamino acid transmembrane transporter activity
Molecular FunctionL-phenylalanine transmembrane transporter activity
Molecular FunctionL-proline transmembrane transporter activity
Biological Processamino acid transmembrane transport
Biological Processamino acid transport
Biological Processserine import across plasma membrane
Biological Processtransmembrane transport

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    General amino acid permease AGP1
  • Alternative names
    • Asparagine/glutamine permease

Gene names

    • Name
      AGP1
    • ORF names
      YCL25C
    • Ordered locus names
      YCL025C

Organism names

Accessions

  • Primary accession
    P25376
  • Secondary accessions
    • D6VQZ1

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-124Cytoplasmic
Transmembrane125-145Helical
Topological domain146-148Extracellular
Transmembrane149-169Helical
Topological domain170-197Cytoplasmic
Transmembrane198-218Helical
Topological domain219-231Extracellular
Transmembrane232-252Helical
Topological domain253-260Cytoplasmic
Transmembrane261-281Helical
Topological domain282-313Extracellular
Transmembrane314-334Helical
Topological domain335-352Cytoplasmic
Transmembrane353-373Helical
Topological domain374-402Extracellular
Transmembrane403-425Helical
Topological domain426-452Cytoplasmic
Transmembrane453-473Helical
Topological domain474-477Extracellular
Transmembrane478-498Helical
Topological domain499-531Cytoplasmic
Transmembrane532-552Helical
Topological domain553-560Extracellular
Transmembrane561-581Helical
Topological domain582-633Cytoplasmic

Keywords

Phenotypes & Variants

Variants

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The viewer provides 10 variants from UniProt as well as other sources including ClinVar and dbSNP.

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Chemistry

PTM/Processing

Features

Showing features for chain, modified residue, cross-link, lipidation.

Type
IDPosition(s)Description
ChainPRO_00000541421-633General amino acid permease AGP1
Modified residue6Phosphoserine
Cross-link11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Lipidation633S-palmitoyl cysteine

Post-translational modification

Palmitoylated by PFA4.

Keywords

Proteomic databases

PTM databases

Expression

Induction

Induced by transcription factors DAL81 and STP1, which are activated by a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system in response to external amino acid levels.

Interaction

Protein-protein interaction databases

Chemistry

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias32-50Polar residues
Region32-52Disordered
Compositional bias86-115Polar residues
Region86-116Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    633
  • Mass (Da)
    69,671
  • Last updated
    2008-04-29 v3
  • Checksum
    8E19A836C2F6C50F
MSSSKSLYELKDLKNSSTEIHATGQDNEIEYFETGSNDRPSSQPHLGYEQHNTSAVRRFFDSFKRADQGPQDEVEATQMNDLTSAISPSSRQAQELEKNESSDNIGANTGHKSDSLKKTIQPRHVLMIALGTGIGTGLLVGNGTALVHAGPAGLLIGYAIMGSILYCIIQACGEMALVYSNLTGGYNAYPSFLVDDGFGFAVAWVYCLQWLCVCPLELVTASMTIKYWTTSVNPDVFVIIFYVLVITINIFGARGYAEAEFFFNCCKILMMTGFFILGIIIDVGGAGNDGFIGGKYWHDPGAFNGKHAIDRFKGVAATLVTAAFAFGGSEFIAITTAEQSNPRKAIPGAAKQMIYRILFLFLATIILLGFLVPYNSDQLLGSTGGGTKASPYVIAVASHGVRVVPHFINAVILLSVLSMANSSFYSSARLFLTLSEQGYAPKVFSYIDRAGRPLIAMGVSALFAVIAFCAASPKEEQVFTWLLAISGLSQLFTWTAICLSHLRFRRAMKVQGRSLGELGFKSQTGVWGSAYACIMMILILIAQFWVAIAPIGEGKLDAQAFFENYLAMPILIALYVGYKVWHKDWKLFIRADKIDLDSHRQIFDEELIKQEDEEYRERLRNGPYWKRVVAFWC

Sequence caution

The sequence CAA42360.2 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias32-50Polar residues
Compositional bias86-115Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X59720
EMBL· GenBank· DDBJ
CAA42360.2
EMBL· GenBank· DDBJ
Genomic DNA Frameshift
BK006937
EMBL· GenBank· DDBJ
DAA07460.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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