P25367 · RNQ1_YEAST

Function

function

Transferable epigenetic modifier which forms a prion responsible for the non-Mendelian trait [PIN+]. The native function of the soluble protein is unknown.

Miscellaneous

[PIN+], also known as [RNQ+], is the prion form of RNQ1 (PubMed:10678178).
[PIN+] is the result of a conformational change of the cellular RNQ1 protein that becomes self-propagating and infectious. This conformational change generates a form of RNQ1 that assembles into amyloid fibrils (PubMed:17097676).
[PIN+] promotes de novo [PSI+] formation upon SUP35 overproduction (cross-seeding) (PubMed:11511345).
[PIN+] can be cured by GdnHCl and by deletion of the molecular chaperone HSP104, which is required for [PIN+] propagation (PubMed:10678178).
Present with 1140 molecules/cell in log phase SD medium.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functionidentical protein binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    [PIN+] prion protein RNQ1
  • Alternative names
    • Rich in asparagine and glutamine protein 1

Gene names

    • Name
      RNQ1
    • ORF names
      YCL181, YCL28W
    • Ordered locus names
      YCL028W

Organism names

Accessions

  • Primary accession
    P25367
  • Secondary accessions
    • D6VQY7
    • Q8NKJ9
    • Q8TF94
    • Q8TFA2
    • Q8TFC8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant166-169in strain: SCI7.2/b, SCI11.5/a and SCI11.5/c
Natural variant171-172in strain: SCI7.2/a, SCI7.2/d, SCI11.5/b and SCI11.5/d
Natural variant289-299in strain: SCI7.2/b, SCI7.2/d and SCI11.5/c
Natural variant293-303in strain: SCI9
Natural variant360in strain: SCI3, SCI4, SCI7.2/a, SCI7.2/b, SCI7.2/d, SCI11.5/a, SCI11.5/b, SCI11.5/c and SCI11.5/d
Natural variant372in strain: SCI7.2/b, SCI7.2/d and SCI11.5/c
Natural variant383in strain: SCI7.2/b,SCI7.2/d and SCI11.5/c
Natural variant387in strain: SCI4

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 16 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, cross-link, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000973901-405[PIN+] prion protein RNQ1
Cross-link5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cross-link84Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residue143Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P25367RNQ1 P253676EBI-21708, EBI-21708
BINARY P25367SIS1 P252943EBI-21708, EBI-17244

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region149-172Disordered
Region153-402Prion domain (PrD)
Region185-405Disordered

Domain

The prion domain (PrD) is a Gln/Asn (Q/N)-rich domain, which is unstructured in its native, soluble form, and which forms a parallel in-register beta-sheet in its amyloid form.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    405
  • Mass (Da)
    42,580
  • Last updated
    2004-04-26 v2
  • Checksum
    8ED9C40A7DF70F7F
MDTDKLISEAESHFSQGNHAEAVAKLTSAAQSNPNDEQMSTIESLIQKIAGYVMDNRSGGSDASQDRAAGGGSSFMNTLMADSKGSSQTQLGKLALLATVMTHSSNKGSSNRGFDVGTVMSMLSGSGGGSQSMGASGLAALASQFFKSGNNSQGQGQGQGQGQGQGQGQGQGSFTALASLASSFMNSNNNNQQGQNQSSGGSSFGALASMASSFMHSNNNQNSNNSQQGYNQSYQNGNQNSQGYNNQQYQGGNGGYQQQQGQSGGAFSSLASMAQSYLGGGQTQSNQQQYNQQGQNNQQQYQQQGQNYQHQQQGQQQQQGHSSSFSALASMASSYLGNNSNSNSSYGGQQQANEYGRPQQNGQQQSNEYGRPQYGGNQNSNGQHESFNFSGNFSQQNNNGNQNRY

Sequence caution

The sequence AAA34615.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict181in Ref. 1; AAA34615

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M16717
EMBL· GenBank· DDBJ
AAA34615.1
EMBL· GenBank· DDBJ
Genomic DNA Frameshift
X59720
EMBL· GenBank· DDBJ
CAC42958.1
EMBL· GenBank· DDBJ
Genomic DNA
AY028674
EMBL· GenBank· DDBJ
AAK26208.1
EMBL· GenBank· DDBJ
Genomic DNA
AY028675
EMBL· GenBank· DDBJ
AAK26209.1
EMBL· GenBank· DDBJ
Genomic DNA
AY028676
EMBL· GenBank· DDBJ
AAK26210.1
EMBL· GenBank· DDBJ
Genomic DNA
AY028677
EMBL· GenBank· DDBJ
AAK26211.1
EMBL· GenBank· DDBJ
Genomic DNA
AY028678
EMBL· GenBank· DDBJ
AAK26212.1
EMBL· GenBank· DDBJ
Genomic DNA
AY028679
EMBL· GenBank· DDBJ
AAK26213.1
EMBL· GenBank· DDBJ
Genomic DNA
AY028680
EMBL· GenBank· DDBJ
AAK26214.1
EMBL· GenBank· DDBJ
Genomic DNA
AY028681
EMBL· GenBank· DDBJ
AAK26215.1
EMBL· GenBank· DDBJ
Genomic DNA
AY028682
EMBL· GenBank· DDBJ
AAK26216.1
EMBL· GenBank· DDBJ
Genomic DNA
AY028683
EMBL· GenBank· DDBJ
AAK26217.1
EMBL· GenBank· DDBJ
Genomic DNA
AY028684
EMBL· GenBank· DDBJ
AAK26218.1
EMBL· GenBank· DDBJ
Genomic DNA
AY028685
EMBL· GenBank· DDBJ
AAK26219.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006937
EMBL· GenBank· DDBJ
DAA07456.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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