P25353 · NPP1_YEAST

Function

function

Mediates extracellular nucleotide derived phosphate hydrolysis along with NPP2 and PHO5.

Miscellaneous

Present with 3420 molecules/cell in log phase SD medium.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site219Nucleophile

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionnucleoside triphosphate diphosphatase activity
Molecular Functionphosphodiesterase I activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Biological Processcellular response to phosphate starvation
Biological Processnucleoside triphosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ectonucleotide pyrophosphatase/phosphodiesterase 1
  • Short names
    E-NPP 1

Including 2 domains:

  • Recommended name
    Alkaline phosphodiesterase 1
  • EC number
  • Recommended name
    Nucleotide pyrophosphatase
  • EC number
  • Short names
    NPPase
  • Alternative names
    • Nucleotide diphosphatase

Gene names

    • Name
      NPP1
    • ORF names
      YCR246, YCR26C
    • Ordered locus names
      YCR026C

Organism names

Accessions

  • Primary accession
    P25353
  • Secondary accessions
    • D6VR36
    • Q8NIL9

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type II membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-113Cytoplasmic
Transmembrane114-134Helical
Topological domain135-742Extracellular

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00002025661-742Ectonucleotide pyrophosphatase/phosphodiesterase 1
Glycosylation161N-linked (GlcNAc...) asparagine
Glycosylation204N-linked (GlcNAc...) asparagine
Glycosylation264N-linked (GlcNAc...) asparagine
Glycosylation296N-linked (GlcNAc...) asparagine
Glycosylation403N-linked (GlcNAc...) asparagine

Post-translational modification

Autophosphorylated as part of the catalytic cycle of phosphodiesterase/pyrophosphatase activity.
N-glycosylated.

Keywords

Proteomic databases

PTM databases

Expression

Induction

Up-regulated during phosphate starvation.

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region168-545Phosphodiesterase
Region640-670Disordered
Compositional bias643-659Acidic residues
Region686-711Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    742
  • Mass (Da)
    84,734
  • Last updated
    2003-06-27 v2
  • Checksum
    83BD5F00D69B09C5
MELQNDLESLDNELNDFSEDPFRDDFITDEDAVRSGWRSAWTRMKYWFYKNRLKWTNNPIVIGDAKDSRDGSNFRRGIPLYELDANGQPIDTELVDENELSFGTGFHSKVPFKIIFRTLFGSLVFAIFLILMINIAKPHHSTRVLSHFGSPEFDPYVKYFNGTHEFFPLTIVISLDGFHPSLISKRNTPFLHDLYELKYDGGMNITSTPFMVPSFPTETFPNHWTLVTGQYPIHHGIVSNVFWDPDLNEEFHPGVLDPRIWNNNDTEPIWQTVQSAFDGDIPFKAATHMWPGSDVNYTKYNEEKLQPEHKNPIARERTPFYFDEFNAKEPLSQKLSKIIEYVDMSTLNERPQLILGYVPNVDAFGHKHGYPSESEYYYEDFTETLGEVDTFLKQLVESLQERNLTSFTNLVIVSDHGMSDIVVPSNVIIWEDLLDEKLRKDYVSHAYLEGPMMAISLKDSGNINEVYHNLKTSIDEDKYTVYVNGNFPKEWNFNDGKNHHMASIWIVPEPGYAVMKKEQLKKVAKGDHKDKNEDNVFTIGSHGYDNNAIDMRSVFIGMGPYFPQGYIEPFQNTEIYNLLCDICGVAEKDRNSNDGTGMLMNQLREPQSSEEVEIEDDFDYLVSKFGEFSTYNIIWGGYPEETEQDNVDNDNDDNDDGNTDEIAAMPSSSLTIKLEMTTSIPSATETLLGETSPSSRSSSSSSIQASATASTVGDWLQDIINDAKDLIDDIIDSIDDLVDSDT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias643-659Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X59720
EMBL· GenBank· DDBJ
CAC42978.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006937
EMBL· GenBank· DDBJ
DAA07505.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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