The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.
Myc overexpression in the cpk kidney results from the dysregulation of the cystin-necdin regulatory complex and c-Myc in turn contributes to cystogenesis in the cpk mouse.
necdin has multiple roles within protein complexes in different subcellular compartments and indicate that it can utilize multiple karyopherin-dependent pathways to modulate its localization.
These results suggest that necdin downregulates p53 acetylation levels by forming a stable complex with p53 and Sirt1 to protect neurons from DNA damage-induced apoptosis.
These results suggest that paternally expressed necdin facilitates the differentiation and specification of GABAergic neurons in cooperation with Dlx homeodomain proteins.
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