P25233 · NECD_MOUSE
- ProteinNecdin
- GeneNdn
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids325 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Publications for P25233
The mouse Necdin gene is expressed from the paternal allele only and lies in the 7C region of the mouse chromosome 7, a region of conserved synteny to the human Prader-Willi syndrome region.
- CategorySequences
- SourceMGI: 97290
- PubMed
- Europe PMC
- Eur J Hum Genet 5:324-332 ()
Mapped toThe necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse.
- AnnotationThe necdin gene is imprinted with preferential expression from the paternal allele in human and mouse.
- CategoriesSequences, Expression
Biochemical characterization of mouse brain necdin.
- CategoriesFunction, Sequences, Subcellular Location
- SourceMGI: 97290
Arrest of cell growth by necdin, a nuclear protein expressed in postmitotic neurons.
- CategorySubcellular Location
- SourceMGI: 97290
Identification and characterization of Necdin as a target for the Cockayne syndrome B protein in promoting neuronal differentiation and maintenance.
- AnnotationIdentification and characterization of Necdin as a target for the Cockayne syndrome B protein in promoting neuronal differentiation and maintenance.
- CategoryFunction
- SourceGeneRif: 17984
Necdin, one of the important pathway proteins in the regulation of osteosarcoma progression by microRNA-200c.
- AnnotationNecdin one of the important pathway proteins in the regulation of osteosarcoma progression by microRNA-200c.
- CategoriesFunction, Expression
- SourceGeneRif: 17984
Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications.
- AnnotationGenetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications.
- CategoriesFunction, Phenotypes & Variants
Necdin regulates BMAL1 stability and circadian clock through SGT1-HSP90 chaperone machinery.
- AnnotationNecdin regulates BMAL1 stability and circadian clock through SGT1-HSP90 chaperone machinery.
- CategoriesFunction, Interaction
The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.
- AnnotationThe necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry.
- CategoryInteraction
- SourceGeneRif: 17984
SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation.
- AnnotationSENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation.
- CategoryFunction
Necdin shapes serotonergic development and SERT activity modulating breathing in a mouse model for Prader-Willi syndrome.
- AnnotationOverall these results demonstrate that an increase of SERT activity is sufficient to cause the apneas in Necdin-knockout pups.
- CategoriesFunction, Phenotypes & Variants
Necdin modulates osteogenic cell differentiation by regulating Dlx5 and MAGE-D1.
- AnnotationThe Necdin expression was further associated with suppression of both cell proliferation and death in osteoblasts.
- CategoriesFunction, Expression
- SourceGeneRif: 17984
Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.
- AnnotationData reveal that necdin promotes mitochondrial biogenesis through stabilization of endogenous PGC-1alpha to exert neuroprotection against mitochondrial insults.
- CategoriesFunction, Subcellular Location
MALA-2, mouse homologue of human adhesion molecule ICAM-1 (CD54).
- CategorySequences
- SourceMGI: 97290
Imprinting analysis of the mouse chromosome 7C region in DNMT1-null embryos.
- CategoryExpression
- SourceMGI: 97290
Mapped toThe alpha subunit of Go modulates cell proliferation and differentiation through interactions with Necdin.
- AnnotationNecdin is a candidate downstream effector for Galphao.
- CategoryInteraction
Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase.
- AnnotationOur data suggest that necdin suppresses PIAS1 both by inhibiting SUMO E3 ligase activity and by promoting ubiquitin-dependent degradation.
- CategoriesPTM / Processing, Interaction
Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line.
- CategoriesSequences, Expression
- SourceMGI: 97290
Antagonistic interplay between necdin and Bmi1 controls proliferation of neural precursor cells in the embryonic mouse neocortex.
- AnnotationAntagonistic interplay between necdin and Bmi1 controls proliferation of neural precursor cells in the embryonic mouse neocortex.
- CategoriesFunction, Expression, Interaction